Publications by Professor Thomas von Zglinicki - ePrints

Browsing publications by Professor Thomas von Zglinicki.

Newcastle Authors	Title	Year
João Novo Lucy Gee Professor Thomas von Zglinicki Dr Diana Jurk	Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence	2024
Dr Mikolaj Ogrodnik Professor Thomas von Zglinicki	Guidelines for minimal information on cellular senescence experimentation in vivo	2024
Jemma Castle Dr Ed Fielder Mankaran Singh Professor Roderick Skinner Professor Thomas von Zglinicki et al.	In vivo modeling recapitulates radiotherapy delivery and late-effect profile for childhood medulloblastoma	2024
Dr Ed Fielder Abbas Ishaq Evon Low Aisha Calista Jemma Castle et al.	Mild Uncoupling of Mitochondria Synergistically Enhances Senolytic Specificity and Sensitivity of BH3 Mimetics	2024
Evon Low Dr Lucy Smith Dr Satomi Miwa Dr Ed Fielder Professor Thomas von Zglinicki et al.	Senescent Dermal Fibroblasts Decrease Stemness in Basal Keratinocytes in a Bioengineered Model of Human Full-Thickness Skin	2024
George Kelly Dr Tetsushi Kataura Dr Johan Panek Hanna Salmonowicz Hannah Kendall et al.	Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule	2024
Professor Thomas von Zglinicki	An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence	2023
Dr Antoneta Granic Dr Carmen Martin-Ruiz Lucy Rimmer Dr Richard Dodds Dr Louise Robinson et al.	Immunosenescence profiles of lymphocyte compartments and multiple long-term conditions (multimorbidity) in very old adults: The Newcastle 85+ Study	2022
Dr Kate Rennie Professor Miles Witham Penny Bradley Professor Helen Hancock Shaun Hiu et al.	MET-PREVENT: metformin to improve physical performance in older people with sarcopenia and physical prefrailty/frailty - protocol for a double-blind, randomised controlled proof-of-concept trial	2022
Dr Satomi Miwa Professor Thomas von Zglinicki	Mitochondrial dysfunction in cell senescence and aging	2022
Dr Ed Fielder Dr Tengfei Wan Ghazaleh Alimohammadiha Abbas Ishaq Evon Low et al.	Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice	2022
Evon Low Ghazaleh Alimohammadiha Lydia Costello Professor Thomas von Zglinicki Dr Satomi Miwa et al.	How good is the evidence that cellular senescence causes skin ageing?	2021
Dr Jack Leslie Dr Marie-Helene Ruchaud Amy Collins Leena Habiballa Dr Gabi Saretzki et al.	Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner	2021
Professor Thomas von Zglinicki Dr Tengfei Wan Dr Satomi Miwa	Senescence in Post-Mitotic Cells: A Driver of Aging?	2021
Dr Satomi Miwa Professor Thomas von Zglinicki	Surprisingly long survival of premature conclusions about naked mole-rat biology	2021
Dr Ed Fielder Professor Thomas von Zglinicki	Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice	2021
Dr Ed Fielder Dr Clare Tweedy Dr Caroline Wilson Professor Fiona Oakley Dr Fiona LeBeau et al.	Anti-inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice	2020
Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki Professor Gavin Richardson Lilia Draganova Dr Rachael Redgrave et al.	CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians	2020
Dr Antoneta Granic Dr Carmen Martin-Ruiz Dr Richard Dodds Professor Dame Louise Robinson Professor Ioakim Spyridopoulos et al.	Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study	2020
Dr Carmen Martin-Ruiz Professor Alison Yarnall Dr John Boucher Dr Rachael Lawson Claire Kolenda et al.	Senescence and inflammatory markers for predicting clinical progression in Parkinson's disease-the ICICLE-PD study	2020
Dr Glyn Nelson Professor Thomas von Zglinicki	Bioengineering the microanatomy of human skin	2019
Dr Diana Jurk Dr Joao Passos Professor Thomas von Zglinicki	Cellular Senescence: Defining a Path Forward	2019
Dr Mikolaj Ogrodnik Patrick Kruger Dr Ed Fielder Stella Victorelli Rifqha Ruswhandi et al.	Obesity-Induced Cellular Senescence Drives Anxiety And Impairs Neurogenesis	2019
Dr Ed Fielder Dr Satomi Miwa Professor Thomas von Zglinicki	Senolytics and senostatics as adjuvant tumour therapy	2019
Professor Melissa Bateson Dr Carmen Martin-Ruiz Gillian Pepper Professor Thomas von Zglinicki Professor Daniel Nettle et al.	Smoking does not accelerate leucocyte telomere attrition: A meta-analysis of 18 longitudinal cohorts	2019
Dr Ed Fielder Julien Agneessens Brigid Griffin Dr Craig Parker Dr Satomi Miwa et al.	Sublethal whole-body irradiation causes progressive premature frailty in mice	2019
Dr Mikolaj Ogrodnik Dr Diana Jurk Professor Thomas von Zglinicki	Targeting senescent cells alleviates obesity-induced metabolic dysfunction	2019
Dr Mikolaj Ogrodnik Dr Olena Kucheryavenko Julien Glibert Dr Satomi Miwa Abbas Ishaq et al.	The bystander effect contributes to the accumulation of senescent cells in vivo	2019
Dr Olena Kucheryavenko Dr Glyn Nelson Professor Thomas von Zglinicki Professor Viktor Korolchuk Dr Bernadette Carroll et al.	The mTORC1-autophagy pathway is a target for senescent cell elimination	2019
Abbas Ishaq Julia Schroder Miss Edwards Professor Thomas von Zglinicki Dr Gabriele Saretzki et al.	Dietary restriction ameliorates age-related increase in DNA damage, senescence and inflammation in mouse adipose tissuey	2018
Abbas Ishaq Damien Dufour Dr Kerry Cameron Professor Thomas von Zglinicki Dr Gabriele Saretzki et al.	Metabolic memory of dietary restriction ameliorates DNA damage and adipocyte size in mouse visceral adipose tissue	2018
Dr Glyn Nelson Dr Olena Kucheryavenko James Wordsworth Professor Thomas von Zglinicki	The senescent bystander effect is caused by ROS-activated NF-κB signalling	2018
Dr Diana Jurk Professor Thomas von Zglinicki	17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization	2017
Dr Mikolaj Ogrodnik Dr Satomi Miwa Dr Dina Tiniakos Dr Caroline Wilson Professor Chris Day et al.	Cellular senescence drives age-dependent hepatic steatosis	2017
Dr Antoneta Granic Dr Karen Davies Dr Carmen Martin-Ruiz Emerita Professor Carol Jagger Emeritus Professor Thomas Kirkwood et al.	Grip strength and inflammatory biomarker profiles in very old adults	2017
Professor Viktor Korolchuk Dr Satomi Miwa Dr Bernadette Carroll Professor Thomas von Zglinicki	Mitochondria in cell senescence: Is mitophagy the weakest link?	2017
Dr Bernadette Carroll Dr Glyn Nelson Dr Yoana Rabanal Ruiz Dr Olena Kucheryavenko Professor Penny Lovat et al.	Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing	2017
Dr Sabine Langie Dr Kerry Cameron Bartlomiej Tomaszewski Professor Thomas von Zglinicki Professor John Mathers et al.	The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice	2017
Dr Ed Fielder Professor Thomas von Zglinicki Dr Diana Jurk	The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?	2017
Professor Roderick Skinner Professor Thomas von Zglinicki	Accelerated Aging in Bone Marrow Transplant Survivors	2016
Dr Satomi Miwa Dr Achim Treumann Amy Bell Dr Glyn Nelson Professor Thomas von Zglinicki et al.	Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H₂O₂ release assays	2016
Professor Ioakim Spyridopoulos Dr Carmen Martin-Ruiz Professor Catharien Hilkens Mohammad Yadegarfar Professor John Isaacs et al.	CMV-seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians - results from the Newcastle 85+ study	2016
Professor Thomas von Zglinicki Dr Satomi Miwa	Data from molecular dynamics simulations in support of the role of human CES1 in the hydrolysis of Amplex Red	2016
Dr Satomi Miwa Dr Rafal Czapiewski Tengfei Wan Amy Bell Kirsten Hill et al.	Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria	2016
Dr Carmen Martin-Ruiz Simon Cox Professor Thomas von Zglinicki	Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921	2016
Dr Clara Correia Melo Francisco Marques Rhys Anderson Dr Graeme Hewitt Dr Bernadette Carroll et al.	Mitochondria are required for pro-ageing features of the senescent phenotype	2016
Dr Graeme Hewitt Dr Bernadette Carroll Dr Clara Correia Melo Mikolaj Ogrodnik Dr Glyn Nelson et al.	SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair	2016
Professor Bob Anderson Dr Simon Tual-Chalot Dr Rachael Redgrave Rebecca Dodds Dr Andrew Owens et al.	The role of cardiomyocyte senescence and regeneration in Ageing	2016
Dr Antoneta Granic Dr Terry Aspray Professor Thomas Hill Dr Karen Davies Dr Joanna Collerton et al.	25-hydroxyvitamin D and increased all-cause mortality in very old women: the Newcastle 85+ study	2015
Dr Joanna Collerton Dr Carmen Martin-Ruiz Emerita Professor Carol Jagger Professor Thomas von Zglinicki Emeritus Professor Thomas Kirkwood et al.	Age-related frailty and its association with biological markers of ageing	2015
Dr Sushma Grellscheid Dr David Dolan Dr Darren Daniels Professor Thomas von Zglinicki	Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts	2015
Dr Carmen Martin-Ruiz Professor Rachel Cooper Dr Andrew Kingston Professor Thomas von Zglinicki	Corrigendum to "Reproducibility of Telomere Length Assessment - An International Collaborative Study" [International Journal of Epidemiology 2014, doi: 10.1093/ije/dyu191]	2015
Dr Yasumichi Arai Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki	Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians	2015
Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki	Is Southern blotting necessary to measure telomere length reproducibly? Authors' Response to: Commentary: The reliability of telomere length measurements	2015
Professor Thomas von Zglinicki	Live long, live well	2015
Jedrzej Hoffmann Dr Evgeniya Shmeleva Dr Stephen Boag Dr Karel Fiser Dr Alan Bagnall et al.	Myocardial Ischemia and Reperfusion Leads to Transient CD8 Immune Deficiency and Accelerated Immunosenescence in CMV-Seropositive Patients	2015
Dr Carmen Martin-Ruiz Dr Andrew Kingston Professor Thomas von Zglinicki	Reproducibility of telomere length assessment: an international collaborative study	2015
Dr Carmen Martin-Ruiz Dr Andrew Kingston Professor Thomas von Zglinicki	Reproducibility of telomere length assessment: Authors' Response to Damjan Krstajic and Ljubomir Buturovic	2015
Dr Antoneta Granic Professor Thomas Hill Emeritus Professor Thomas Kirkwood Dr Karen Davies Dr Joanna Collerton et al.	Serum 25-hydroxyvitamin D and cognitive decline in the very old: The Newcastle 85+ study	2015
Dr Joanna Collerton Hannah Gautrey Sanne van Otterdijk Dr Karen Davies Dr Carmen Martin-Ruiz et al.	Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+Study	2014
Dr Kirstie Anderson Professor Mike Catt Dr Joanna Collerton Dr Karen Davies Professor Thomas von Zglinicki et al.	Assessment of sleep and circadian rhythm disorders in the very old: the Newcastle 85+ Cohort Study	2014
Dr Karim Bennaceur Mark Atwill Nayef Al Zhrany Jedrzej Hoffmann Professor Bernard Keavney et al.	Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism	2014
Dr Diana Jurk Dr Caroline Wilson Dr Joao Passos Professor Fiona Oakley Clara Correia Melo et al.	Chronic inflammation induces telomere dysfunction and accelerates ageing in mice	2014
Dr Piero Dalle Pezze Dr Glyn Nelson Gisela Otten Professor Viktor Korolchuk Emeritus Professor Thomas Kirkwood et al.	Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions	2014
Laura Wiley Dr Carmen Martin-Ruiz Emerita Professor Carol Jagger Mohammad Yadegarfar Professor Thomas von Zglinicki et al.	Gender and telomere length: Systematic review and meta-analysis	2014
Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki Professor Avan Sayer	Inflammation, telomere length, and grip strength: a 10-year longitudinal study.	2014
Dr Satomi Miwa Dr Howsun Jow Karen Baty Amy Bell Dr Rafal Czapiewski et al.	Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice	2014
Laura Wiley Deepthi Ashok Dr Carmen Martin-Ruiz David Talbot Dr Joanna Collerton et al.	Reactive Oxygen Species Production and Mitochondrial Dysfunction in White Blood Cells Are Not Valid Biomarkers of Ageing in the Very Old	2014
Professor Ioakim Spyridopoulos Professor Thomas von Zglinicki	Telomere length predicts cardiovascular disease	2014
Dr Antoneta Granic Emeritus Professor Thomas Kirkwood Dr Karen Davies Dr Joanna Collerton Professor Thomas Hill et al.	25-hydroxyvitamin D and increased risk of all-cause mortality in very old women: The Newcastle 85+ study.	2013
Dr John Brain Dr Helen Robertson Dr Aaron Ions Gardner Dr Trevor Booth Professor Thomas von Zglinicki et al.	Biliary Epithelial Senescence and Plasticity in Acute Cellular Rejection	2013
Dr Graeme Hewitt Professor Thomas von Zglinicki Dr Joao Passos	Cell sorting of young and senescent cells	2013
Dr Glyn Nelson Professor Thomas von Zglinicki	Chapter 14, Monitoring DNA Damage During Cell Senescence	2013
Joanna GÓRNIAK Dr Sabine Langie Professor Thomas von Zglinicki Professor Jelena Mann Professor John Mathers et al.	Epigenetic regulation of DNA base excision repair during ageing and dietary restriction	2013
Dr Joanna Collerton Dr Angela Pyle Professor Gavin Hudson Mohammad Yadegarfar Dr Karen Davies et al.	Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old	2013
Christos Gavriilidis Dr Satomi Miwa Professor Thomas von Zglinicki Professor Robert Taylor Professor David Young et al.	Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2	2013
Dr John Boucher Dr Gordon Duncan Professor Alison Yarnall Professor John O'Brien Professor Thomas von Zglinicki et al.	Telomere length and cognitive impairment in early Parkinson's disease	2013
Joanna GÓRNIAK Dr Kerry Cameron Dr Kevin Waldron Professor Thomas von Zglinicki Professor John Mathers et al.	Tissue differences in BER-related incision activity and non-specific nuclease activity as measured by the comet assay	2013
Dr Glyn Nelson James Wordsworth Dr Diana Jurk Dr Conor Lawless Dr Carmen Martin-Ruiz et al.	A senescent cell bystander effect: senescence-induced senescence	2012
Dr Conor Lawless Dr Diana Jurk Dr Colin Gillespie Dr Daryl Shanley Dr Gabriele Saretzki et al.	A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations	2012
Professor Mark Pearce Dr Kay Mann Dr Carmen Martin-Ruiz Professor Louise Parker Professor Martin White et al.	Childhood Growth, IQ and Education as Predictors of White Blood Cell Telomere Length at Age 49-51 Years: The Newcastle Thousand Families Study	2012
Dr Joanna Collerton Dr Carmen Martin-Ruiz karen Davies Professor Mike Catt Emerita Professor Carol Jagger et al.	Frailty and biomarkers of inflammation, immunoscience and cellular ageing in the Newcastle 85+ Study	2012
Dr Joanna Collerton Dr Carmen Martin-Ruiz karen Davies Professor Catharien Hilkens Professor John Isaacs et al.	Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study	2012
Emerita Professor Carol Jagger Professor John Bond Professor Dame Louise Robinson Dr Andrew Kingston Dr Joanna Collerton et al.	Gender differences in the association between self-rated health and mortality: Results from the Newcastle 85+ Study	2012
Jedrzej Hoffmann Dr Karel Fiser Dr Jolanta Weaver Ian Dimmick Monika Loeher et al.	High-Throughput 13-Parameter Immunophenotyping Identifies Shifts in the Circulating T-Cell Compartment Following Reperfusion in Patients with Acute Myocardial Infarction	2012
Dr Satomi Miwa Dr Howsun Jow Dr Achim Treumann Professor Thomas von Zglinicki	Low abundance of the matrix arm of complex I of mice liver mitochondria predicts longevity	2012
Dr Joao Passos Professor Thomas von Zglinicki	Mitochondrial dysfunction and cell senescence - skin deep into mammalian aging	2012
Dr Diana Jurk Chunfang Wang Dr Satomi Miwa Mandy Maddick Professor Viktor Korolchuk et al.	Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response	2012
Sofia Lisanti Professor Thomas von Zglinicki Professor John Mathers	Standardization and quality controls for the methylated DNA immunoprecipitation technique	2012
Dr Diana Jurk Professor Thomas von Zglinicki	Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver	2012
Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki	Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936	2012
Avgi Tsolou Dr Glyn Nelson Dr Gabriele Saretzki Professor Thomas von Zglinicki	The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult	2012
Dr Andrew Golightly Professor Richard Boys Professor Thomas von Zglinicki	The effect of late onset, short-term caloric restriction on the core temperature and physical activity in mice	2012
Dr Irina Neganova Dr Stuart Atkinson Dr Joao Passos Professor Thomas von Zglinicki Professor Lyle Armstrong et al.	An Important Role for CDK2 in G1 to S Checkpoint Activation and DNA Damage Response in Human Embryonic Stem Cells	2011
Dr Carmen Martin-Ruiz Emerita Professor Carol Jagger Dr Andrew Kingston Dr Joanna Collerton Professor Mike Catt et al.	Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study	2011
Emerita Professor Carol Jagger Dr Joanna Collerton Dr Karen Davies Dr Andrew Kingston Professor Dame Louise Robinson et al.	Capability and dependency in the Newcastle 85+ cohort study. Projections of future care needs	2011
Professor Thomas von Zglinicki Professor Christopher Hutchison	Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation	2011
Dr Kerry Cameron Dr Andrew Golightly Dr Satomi Miwa Professor Richard Boys Professor Thomas von Zglinicki et al.	Gross energy metabolism in mice under late onset, short term caloric restriction	2011
Dr Sabine Langie Dr Kerry Cameron Dr Kevin Waldron Professor Thomas von Zglinicki Professor John Mathers et al.	Measuring DNA repair incision activity of mouse tissue extracts towards singlet oxygen-induced DNA damage: a comet-based in vitro repair assay	2011
Wendy den Elzen Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki Emeritus Professor Thomas Kirkwood	Telomere length and anaemia in old age: results from the Newcastle 85-plus Study* and the Leiden 85-plus Study	2011
Mandy Maddick Dr Satomi Miwa Dr Diana Jurk Dr Rafal Czapiewski Dr Gabriele Saretzki et al.	Adult-onset, short-term dietary restriction reduces cell senescence in mice	2010
Emeritus Professor Thomas Kirkwood Dr Carmen Martin-Ruiz Emerita Professor Carol Jagger Dr Joanna Collerton Dr Andrew Kingston et al.	Biomarkers of ageing and their relationship to disability and cognition [abstract]	2010
Dr Satomi Miwa Dr Conor Lawless Professor Thomas von Zglinicki	Correction of radiolabel pulse-chase data by a mathematical model: application to mitochondrial turnover studies	2010
Emerita Professor Carol Jagger Dr Joanna Collerton Professor Dame Louise Robinson Professor Martin Eccles Dr Andrew Kingston et al.	Disability and dependency: How much care is in the community? [abstract]	2010
Sofia Lisanti Professor Thomas von Zglinicki Professor John Mathers	Epigenomics: Understanding How Nutrition Modulates the Ageing Process [abstract]	2010
Professor Thomas von Zglinicki	Fat tissue, aging, and cellular senescence	2010
Dr Joao Passos Dr Glyn Nelson Dr Cedric Simillion Dr Carole Proctor Dr Satomi Miwa et al.	Feedback between p21 and reactive oxygen production is necessary for cell senescence	2010
Dr Conor Lawless Dr Diana Jurk Alina Merz Professor Thomas von Zglinicki Dr Joao Passos et al.	Quantitative assessment of markers for cell senescence	2010
Dr Carmen Martin-Ruiz Dr Aurora Gomez Duran Professor Thomas von Zglinicki	Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations	2009
Dr Joao Passos Dr Cedric Simillion Dr Jennifer Hallinan Professor Anil Wipat Professor Thomas von Zglinicki et al.	Cellular senescence: Unravelling complexity	2009
Dr Glyn Nelson Professor Thomas von Zglinicki	DNA damage foci in mitosis are devoid of 53BP1	2009
Chunfang Wang Dr Diana Jurk Mandy Maddick Dr Glyn Nelson Dr Carmen Martin-Ruiz et al.	DNA damage response and cellular senescence in tissues of aging mice	2009
Dr Joanna Collerton Dr Karen Davies Emerita Professor Carol Jagger Dr Andrew Kingston Professor John Bond et al.	Health and disease in 85 year olds: Baseline findings from the Newcastle 85+ cohort study	2009
Mandy Maddick Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki	Sustained replication in endometrium of women with endometriosis occurs without evoking a DNA damage response	2009
Dr Shaheda Ahmed Dr Joao Passos Matthew Birket Professor Thomas von Zglinicki	Telomerase protects mitochondria and lowers oxidative stress	2009
Matthew Birket Dr Joao Passos Professor Thomas von Zglinicki Professor Mark Birch-Machin	The Relationship between the Aging- and Photo-Dependent T414G Mitochondrial DNA Mutation with Cellular Senescence and Reactive Oxygen Species Production in Cultured Skin Fibroblasts	2009
Dr Sharon Olijslagers Professor Thomas von Zglinicki	Vulnerability to oxidative stress and different patterns of senescence in human peritoneal mesothelial cell strains	2009
Mandy Maddick Professor Thomas von Zglinicki	Architectural changes in the thymus of aging mice	2008
Dr Gabriele Saretzki Theresia Walter Dr Joao Passos Dr Rebecca Stewart Dr Simon Hoare et al.	Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells	2008
Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki Dr Robin Farquharson	Endometrial telomerase shows specific expression patterns in different types of reproductive failure	2008
Dr Gabriele Saretzki Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki	Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length	2008
Matthew Birket Dr Joao Passos Professor Thomas von Zglinicki Professor Mark Birch-Machin	Investigation of the relationship between the ageing- and photodependent T414G mitochondrial DNA mutation with cellular senescence and reactive oxygen species production in cultured skin fibroblasts	2008
Dr Joao Passos Dr Sharon Olijslagers Professor Thomas von Zglinicki	Mitochondrial dysfunction is a possible cause of accelerated senescence of mesothelial cells exposed to high glucose	2008
Dr Satomi Miwa Dr Conor Lawless Professor Thomas von Zglinicki	Mitochondrial turnover in liver is fast in vivo and is accelerated by dietary restriction: application of a simple dynamic model	2008
Dr Joao Passos Professor Thomas von Zglinicki	Retrograde response, oxidative stress and cellular senescence	2008
Avgi Tsolou Dr Joao Passos Dr Glyn Nelson Dr Yasumichi Arai Professor Thomas von Zglinicki et al.	ssDNA fragments induce cell senescence by telomere uncapping	2008
Dr Saeed Ahmed Dr Joao Passos Matthew Birket Dr Heiko Peters Professor Mark Birch-Machin et al.	Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress	2008
Dr Joao Passos Dr Glyn Nelson Professor Thomas von Zglinicki	Telomeres, Senescence, Oxidative stress and heterogeneity	2008
Dr Joanna Collerton Daniel Collerton Dr Yasumichi Arai Dr Karen Davies Professor Martin Eccles et al.	A comparison of computerized and pencil-and-paper tasks in assessing cognitive function in community-dwelling older people in the Newcastle 85+ pilot study	2007
Professor Thomas von Zglinicki	A continuous correlation between oxidative stress and telomere shortening in fibroblasts	2007
Professor Thomas von Zglinicki	Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation	2007
Dr Joao Passos Dr Gabriele Saretzki Professor Thomas von Zglinicki	DNA damage in telomeres and mitochondria during cellular senescence: Is there a connection?	2007
Professor Mark Pearce Dr Jean Adams Dr Carmen Martin-Ruiz Professor Martin White Professor Thomas von Zglinicki et al.	Growth and white blood cell telomere length at age 50: the Newcastle Thousand Families Study	2007
Dr Joao Passos Professor Thomas von Zglinicki	Methods for cell sorting of young and senescent cells	2007
Dr Joao Passos Professor Thomas von Zglinicki Emeritus Professor Thomas Kirkwood	Mitochondria and ageing: Winning and losing in the numbers game	2007
Professor Thomas von Zglinicki Dr Joao Passos Dr Gabriele Saretzki	Mitochondria and telomeres: Strange bedfellows in cell senescence	2007
Dr Joao Passos Dr Gabriele Saretzki Dr Saeed Ahmed Dr Glyn Nelson Torsten Richter et al.	Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence	2007
Dr Jean Adams Dr Carmen Martin-Ruiz Professor Mark Pearce Professor Martin White Professor Louise Parker et al.	No association between socio-economic status and white blood cell telomere length	2007
Professor Thomas von Zglinicki	Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts	2007
Dr Joao Passos Dr Glyn Nelson Dr Gabriele Saretzki Professor Thomas von Zglinicki	Oxygen free radicals in senescence: Are they signal transducers?	2007
Dr Joao Passos Dr Sharon Olijslagers Dr Gabriele Saretzki Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki et al.	Premature senescence of mesothelial cells is associated with non-telomeric DNA damage	2007
Dr Joanna Collerton Dr Carmen Martin-Ruiz Dr Antoinette Kenny Dr Karen Davies Professor Thomas von Zglinicki et al.	Telomere length is associated with left ventricular function in the oldest old: The Newcastle 85+ study	2007
Dr Joanna Collerton Dr Karen Davies Professor John Bond Professor Martin Eccles Emerita Professor Carol Jagger et al.	The Newcastle 85+ study: Biological, clinical and psychosocial factors associated with healthy ageing: Study protocol	2007
Dr Gabriele Saretzki Dr Glyn Nelson Dr Sharon Olijslagers Professor Thomas von Zglinicki	TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts	2007
Jill Collerton Dr Carmen Martin-Ruiz Dr Karen Davies Professor Thomas von Zglinicki Emeritus Professor Thomas Kirkwood et al.	White blood cell telomere length is associated with left ventricular function in the oldest old: The newcastle 85+study	2007
Matthew Birket Professor Thomas von Zglinicki Professor Mark Birch-Machin	A photoageing-associated mitochondrial DNA mutation with potential functional consequences	2006
Dr Carmen Martin-Ruiz Dr Joao Passos Professor Thomas von Zglinicki	Extended lifespan and long telomeres in rectal fibroblasts from late-onset ulcerative colitis patients	2006
Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki	Fat depot-specific characteristics are retained in strains derived from single human preadipocytes	2006
Dr Joao Passos Dr Gabriele Saretzki Professor Thomas von Zglinicki	Mechanisms and role of oxidative damage to telomeres	2006
Dr Joao Passos Dr Gabriele Saretzki Professor Thomas von Zglinicki	Mechanisms and role of oxidative damage to telomeres	2006
Dr Joao Passos Professor Thomas von Zglinicki Dr Gabriele Saretzki	Mitochondrial dysfunction and cell senescence: Cause or consequence?	2006
Jessie Jeyapalan Dr Gabriele Saretzki Alan Leake Dr Michael Tilby Professor Thomas von Zglinicki et al.	Neuroblastoma cell apoptosis induction after cisplatin treatment is not telomere–dependent	2006
Dr Joao Passos Professor Thomas von Zglinicki	Oxygen free radicals in cell senescence: Are they signal transducers?	2006
Dr Carmen Martin-Ruiz Dr Heather Dickinson Barbara Keys Dr Elise Rowan Professor Rose Anne Kenny et al.	Telomere length predicts poststroke mortality, dementia, and cognitive decline	2006
Dr Mark Boxall Professor Tim Goodship Dr Alison Brown Professor Thomas von Zglinicki	Telomere shortening and haemodialysis	2006
Jessie Jeyapalan Dr Gabriele Saretzki Alan Leake Dr Michael Tilby Professor Thomas von Zglinicki et al.	Tumour-cell apoptosis after cisplatin treatment is not telomere dependent	2006
Professor Thomas von Zglinicki Dr Gabriele Saretzki Susan Jackson	Human cell senescence as a DNA damage response	2005
Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki	Lymphocyte telomere dynamics and telomerase activity in inflammatory bowel disease: Effect of drugs and smoking	2005
Dr Joao Passos Professor Thomas von Zglinicki	Mitochondria, telomeres and cell senescence	2005
Professor Lyle Armstrong Dr Gabriele Saretzki Dr Heiko Peters Ilka Wappler Dr Nicholas Hole et al.	Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage	2005
Emeritus Professor Thomas Kirkwood Professor Thomas von Zglinicki	Science fact and the SENS agenda	2005
Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki	Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: A population-based study	2005
Professor Thomas von Zglinicki Dr Carmen Martin-Ruiz	Telomeres as biomarkers for ageing and age-related diseases	2005
Professor Thomas von Zglinicki Dr Carmen Martin-Ruiz Dr Gabriele Saretzki	Telomeres, cell senescence and human ageing	2005
Tino Kurz Alan Leake Professor Thomas von Zglinicki	Lysosomal redox-active iron is important for oxidative stress-induced DNA damage	2004
Tino Kurz Alan Leake Professor Thomas von Zglinicki	Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage	2004
Dr Jean Adams Professor Martin White Professor Mark Pearce Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki et al.	Socio-economic position, health behaviours and telomere length at age 50: a prospective cohort study	2004
Dr Carmen Martin-Ruiz Dr Gabriele Saretzki Jessie Jeyapalan Professor Thomas von Zglinicki	Stochastic Variation in Telomere Shortening Rate Causes Heterogeneity of Human Fibroblast Replicative Life Span	2004
Dr Gabriele Saretzki Professor Lyle Armstrong Alan Leake Professor Majlinda Lako Professor Thomas von Zglinicki et al.	Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells	2004
Barbara Keys Dr Gabriele Saretzki Professor Thomas von Zglinicki	Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3′-overhang	2004
Jessie Jeyapalan Alan Leake Dr Shaheda Ahmed Dr Gabriele Saretzki Dr Michael Tilby et al.	The role of telomeres in etoposide induced tumor cell death	2004
Professor Thomas von Zglinicki Dr Gabriele Saretzki Susan Jackson	A DNA damage checkpoint response in telomere-initiated senescence	2003
Professor Thomas von Zglinicki	Aging at the Molecular Level	2003
Jessie Jeyapalan Dr Michael Tilby Professor Thomas von Zglinicki	Cisplatin induced neuroblastoma cell death and the involvement of telomeres	2003
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Extracellular superoxide dismutase is a major antioxidant and slows down telomere shortening in human fibroblasts	2003
Professor Thomas von Zglinicki Dr Gabriele Saretzki	Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening	2003
Professor Thomas von Zglinicki	Free radical production and antioxidant defence: A primer	2003
Dr Barry Davies Islay Steele Professor Richard Edmondson Dr Simon Zwolinski Dr Gabriele Saretzki et al.	Immortalisation of human ovarian surface epithelium with telomerase and temperature-senstitive SV40 large T antigen	2003
Tino Kurz Alan Leake Professor Thomas von Zglinicki	Lysosomal redox-active iron is important for oxidative stress-induced DNA damage	2003
Dr Gabriele Saretzki Professor Thomas von Zglinicki	MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress	2003
Dr Mark Boxall Barbara Keys Professor Thomas von Zglinicki Professor Tim Goodship	Peripheral blood mononuclear cell telomere length is unaltered in hemodialysis despite increased oxidative stress.	2003
Professor Thomas von Zglinicki	Replicative senescence and the art of counting	2003
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Telomerase as a promising target for human cancer gene therapy	2003
Professor Thomas von Zglinicki Emeritus Professor Thomas Kirkwood	Telomere-driven replicative senescence is a stress response [2]	2003
Professor Thomas von Zglinicki	Telomeres, telomerase and the cancer cell: An introduction	2003
Professor Thomas von Zglinicki	Telomeric damage in aging	2003
Dr Gabriele Saretzki Professor Thomas von Zglinicki	hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines	2002
Professor Thomas von Zglinicki	Human fibroblasts in vitro senesce with a donor-specific telomere length	2002
Professor Thomas von Zglinicki	Oxidative stress shortens telomeres	2002
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Replicative aging, telomeres, and oxidative stress	2002
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Replicative aging, telomeres, and oxidative stress	2002
Professor Thomas von Zglinicki	Accelerated telomere shortening in Fanconi anemia fibroblasts - A longitudinal study	2001
Dr Gabriele Saretzki Professor Thomas von Zglinicki	BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection	2001
Professor Thomas von Zglinicki	Lipofuscin accumulation in proliferating fibroblasts in vitro: An indicator of oxidative stress	2001
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase	2001
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells	2001
Professor Thomas von Zglinicki Professor Alexander Burkle Emeritus Professor Thomas Kirkwood	Stress, DNA damage and ageing - An integrative approach	2001
Professor Thomas von Zglinicki	Telomeres and replicative senescence: Is it only length that counts?	2001
Professor Thomas von Zglinicki	Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts	2000
Professor Thomas von Zglinicki	Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes	2000
Professor Thomas von Zglinicki	Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts	2000
Professor Thomas von Zglinicki	Protein oxidation and degradation during cellular senescence of human BJ-fibroblasts: Part I -Effects of proliferative senescence	2000
Professor Thomas von Zglinicki	Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts	2000
Professor Thomas von Zglinicki Dr Gabriele Saretzki	Regeneration der Telomeren als Basis zellulaerer Immortalitaet	2000
Professor Thomas von Zglinicki	Research on ageing in Germany	2000
Professor Thomas von Zglinicki	Role of oxidative stress in telomere length regulation and replicative senescence	2000
Professor Thomas von Zglinicki	Role of oxidative stress in telomere length regulation and replicative senescence	2000
Professor Thomas von Zglinicki Dr Gabriele Saretzki	Short telomeres in patients with vascular dementia: An indicator of low antioxidative capacity and a possible risk factor?	2000
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Telomere length as a marker of oxidative stress in primary human fibroblast cultures	2000
Dr Gabriele Saretzki Professor Thomas von Zglinicki	[Replicative senescence as a model of aging: the role of oxidative stress and telomere shortening--an overview]	1999
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Modification of the replicative life-span of human fibroblasts by oxidative stress	1999
Professor Thomas von Zglinicki	Proteolysis and protein turnover in fibroblasts - the role of lipofuscin	1999
Professor Thomas von Zglinicki Dr Gabriele Saretzki	Ribozymes inhibiting the catalytic subunit of human telomerase (hTERT)	1999
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments	1999
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Telomeres and human aging	1999
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Preferential accumulation of single-stranded regions in telomeres of human fibroblasts	1998