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Lookup NU author(s): Dr Joanna Collerton, Dr Angela Pyle, Professor Gavin Hudson, Mohammad Yadegarfar, Dr Karen Davies, Emerita Professor Carol Jagger, Professor Thomas von Zglinicki, Emeritus Professor Thomas Kirkwood, Professor Patrick Chinnery
Inherited genetic variation of mitochondrial DNA (mtDNA) could account for the missing heritability of human longevity and healthy aging. Here, we show no robust association between common genetic variants of mtDNA and frailty (an "unhealthy aging" phenotype) or mortality in 700, more than 85-year-old, participants of the Newcastle 85+ study. Conflicting data from different populations underscore our conclusion that there is currently no compelling link between inherited mtDNA variants and aging.
Author(s): Collerton J, Ashok D, Martin-Ruiz C, Pyle A, Hudson G, Yadegarfar M, Davies K, Jagger C, von Zglinicki T, Kirkwood T, Chinnery P
Publication type: Article
Publication status: Published
Journal: Neurobiology of Aging
Year: 2013
Volume: 34
Issue: 12
Pages: 2889.e1-2889.e4
Print publication date: 30/04/2013
Date deposited: 27/11/2013
ISSN (print): 0197-4580
ISSN (electronic): 1558-1497
Publisher: Elsevier Inc.
URL: http://dx.doi.org/10.1016/j.neurobiolaging.2013.04.001
DOI: 10.1016/j.neurobiolaging.2013.04.001
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