Browse by author
Lookup NU author(s): Professor Thomas von Zglinicki
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Fanconi anemia (FA) is a fatal inherited disease displaying chromosomal instability, disturbances in oxygen metabolism and a high burden of intracellular radical oxygen species. Oxygen radicals can damage DNA including telomeric regions. Insufficient repair results in single strand breaks that can induce accelerated telomere shortening. In a longitudinal study we demonstrate that telomeric DNA is continuously lost at a higher rate in FA fibroblasts compared to healthy controls. Furthermore, we show that this loss is caused rather by an increased shortening per cell division in regularly replicating cells than by apoptosis. © 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Author(s): Adelfalk C, Lorenz M, Serra V, von Zglinicki T, Hirsch-Kauffmann M, Schweiger M
Publication type: Article
Publication status: Published
Journal: FEBS Letters
Year: 2001
Volume: 506
Issue: 1
Pages: 22-26
ISSN (print): 0014-5793
ISSN (electronic): 1873-3468
Publisher: Elsevier BV
URL: http://dx.doi.org/10.1016/S0014-5793(01)02869-1
DOI: 10.1016/S0014-5793(01)02869-1
PubMed id: 11591364
Altmetrics provided by Altmetric
