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Lookup NU author(s): João Novo, Lucy Gee, Professor Thomas von Zglinicki, Dr Diana JurkORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. BBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.
Author(s): Novo JP, Gee L, Caetano CA, Tome I, Vilaca A, von Zglinicki T, Moreira IS, Jurk D, Rosa S, Ferreira L
Publication type: Article
Publication status: Published
Journal: Aging Cell
Year: 2024
Pages: ePub ahead of Print
Online publication date: 15/08/2024
Acceptance date: 26/06/2024
Date deposited: 27/08/2024
ISSN (print): 1474-9718
ISSN (electronic): 1474-9726
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1111/acel.14270
DOI: 10.1111/acel.14270
Data Access Statement: The data that support the findings of this study are available fromthe corresponding author upon reasonable request.
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