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Browsing publications by
Professor David Brooks.
Newcastle Authors
Title
Year
Full text
Professor David Brooks
Capillary dysfunction in healthy elderly APOE ε4 carriers with raised brain Aβ deposition
2024
Professor David Brooks
Performance on complex memory tests is associated with β-amyloid in individuals at risk of developing Alzheimer's disease
2024
Professor David Brooks
Professor Nicola Pavese
Progression of brain cholinergic dysfunction in patients with isolated REM sleep behaviour disorder
2024
Professor David Brooks
Capillary dysfunction correlates with cortical amyloid load in early Alzheimer's disease
2023
Professor David Brooks
Neuroinflammation is independently associated with brain network dysfunction in Alzheimer’s disease
2023
Professor David Brooks
Neuroinflammation is independently associated with brain network dysfunction in Alzheimer’s disease
2023
Professor David Brooks
Selecting the Best Animal Model of Parkinson’s Disease for your Research Purpose: Insight from
In Vivo
PET Imaging Studies
2023
Professor Nicola Pavese
Professor David Brooks
Synaptic Density and Glucose Consumption in Patients with Lewy Body Diseases: An [
11
C]UCB-J and [
18
F]FDG PET Study
2023
Professor Nicola Pavese
Professor David Brooks
Synaptic Density and Glucose Consumption in Patients with Lewy Body Diseases: An [
11
C]UCB-J and [
18
F]FDG PET Study
2023
Dr Emma Lethbridge
Professor David Brooks
The noradrenergic subtype of Parkinson's disease: from animal models to clinical practice
2023
Professor David Brooks
Treadmill exercise modulates nigral and hippocampal cannabinoid receptor type 1 in the 6-OHDA model of Parkinson’s disease
2023
Professor David Brooks
[
18
F]FEOBV positron emission tomography may not be a suitable method to measure parasympathetic denervation in patients with Parkinson's disease
2022
Professor David Brooks
A genetically modified minipig model for Alzheimer’s disease with
SORL1
haploinsufficiency
2022
Professor David Brooks
Asymmetric amyloid deposition in preclinical Alzheimer’s disease: A PET study
2022
Professor David Brooks
Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study
2022
Dr Hilmar Sigurdsson
Professor Alison Yarnall
Dr Brook Galna
Dr Susan Lord
Dr Lisa Alcock
et al.
Gait-related metabolic covariance networks at rest in Parkinson’s disease
2022
Professor David Brooks
Healthy brain aging assessed with [
18
F]FDG and [
11
C]UCB-J PET
2022
Professor David Brooks
In vivo vesicular acetylcholine transporter density in human peripheral organs: an [
18
F]FEOBV PET/CT study
2022
Professor Nicola Pavese
Professor David Brooks
Mapping Cholinergic Synaptic Loss in Parkinson's Disease: An [
18
F]FEOBV PET Case-Control Study
2022
Professor John O'Brien
Professor John-Paul Taylor
Professor David Brooks
Professor Ian McKeith
Professor Alison Yarnall
et al.
RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia—an international Delphi consensus
2022
Professor David Brooks
Spontaneous partial recovery of striatal dopaminergic uptake despite nigral cell loss in asymptomatic MPTP-lesioned female minipigs
2022
Professor David Brooks
Trial of Cinpanemab in Early Parkinson’s Disease
2022
Professor David Brooks
Widespread cell stress and mitochondrial dysfunction in early Alzheimer’s Disease
2022
Professor David Brooks
Activated N-methyl-D-aspartate receptor ion channels detected in focal epilepsy with [
18
F]GE-179 positron emission tomography
2021
Professor Nicola Pavese
Professor David Brooks
Brain microglial activation increased in glucocerebrosidase (GBA1) mutation carriers
2021
Professor David Brooks
Dr Clive Ballard
Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects?
2021
Professor David Brooks
Exercise protects synaptic density in a rat model of Parkinson’s disease
2021
Professor David Brooks
Future imaging in dementia
2021
Professor David Brooks
Imaging Familial and Sporadic Neurodegenerative Disorders associated with Parkinsonism
2021
Professor David Brooks
Professor Nicola Pavese
Impaired cerebral microcirculation in isolated rapid eye movement sleep behaviour disorder
2021
Professor David Brooks
Professor Nicola Pavese
Impulse control disorders are associated with lower ventral striatum dopamine D3 receptor availability in Parkinson's disease: a [
11
C]-PHNO PET study
2021
Professor David Brooks
In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET
2021
Professor David Brooks
Professor Nicola Pavese
Monocyte markers correlate with immune and neuronal brain changes in REM Sleep Behaviour Disorder
2021
Professor David Brooks
Neuroinflammation, functional connectivity and structural network integrity in the Alzheimer's spectrum
2021
Professor David Brooks
NMDA receptor ion channel activation detected in vivo with
[
18
F]GE-179 PET after
electrical stimulation of rat hippocampus
2021
Professor David Brooks
PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats
2021
Professor Nicola Pavese
Professor David Brooks
Preserved noradrenergic function in Parkinson´s disease patients with rest tremor
2021
Dr Kirstie Anderson
Dr Rachael Lawson
Professor David Brooks
Professor Nicola Pavese
Progression of sleep disturbances in Parkinson’s Disease. A 5-year longitudinal study.
2021
Professor David Brooks
Reduced synaptic density in patients with Lewy body dementia: an [
11
C]UCB-J PET imaging study
2021
Professor David Brooks
Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease
2021
Dr Jacopo Pasquini
Professor David Brooks
Professor Nicola Pavese
The Cholinergic Brain in Parkinson's Disease
2021
Professor David Brooks
Activation of NMDA Receptor Ion Channels by Deep Brain Simulation in the Pig Visualised with[
18
F]GE-179 PET
2020
Professor Nicola Pavese
Professor David Brooks
Altered sensorimotor cortex noradrenergic function in idiopathic REM sleep behaviour disorder – a PET study
2020
Professor David Brooks
Amyloid-PET and
18
F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias
2020
Professor Nicola Pavese
Professor David Brooks
Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study
2020
Professor Nicola Pavese
Professor David Brooks
Brain-first vs. Body-first Parkinson’s disease: a multi-modal imaging case-control study
2020
Professor David Brooks
Can autonomic testing and imaging contribute to the early diagnosis of MSA? A systematic review and recommendations by the MDS multiple system atrophy (MoDiMSA) study group
2020
Professor David Brooks
Professor Nicola Pavese
Cholinergic denervation in patients with idiopathic rapid eye movement sleep behaviour disorder
2020
Professor David Brooks
Cortical cholinergic dysfunction correlates with microglial activation in the substantia innominata in REM sleep behavior disorder
2020
Professor David Brooks
EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0
2020
Professor David Brooks
Erratum: Correction to: Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: study protocol for a randomised controlled trial (ELAD study) (Trials (2019) 20 1 (191))
2020
Professor David Brooks
Professor Nicola Pavese
Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers
2020
Rokiah Ismail
Professor David Brooks
Impaired Perfusion And Capillary Dysfunction In Prodromal Alzhemer’s Disease
2020
Professor David Brooks
Low plasma neurofilament light levels associated with raised cortical microglial activation suggest inflammation acts to protect prodromal Alzheimer’s disease
2020
Professor David Brooks
Preclinical PET Studies of [
11
C]UCB-J Binding in Minipig Brain
2020
Professor David Brooks
Tau Tangles in Parkinson’s Disease: A 2-Year Follow-Up Flortaucipir PET Study
2020
Professor David Brooks
The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer’s disease: a longitudinal PET study
2020
Professor David Brooks
Abnormal Amyloid Load in Mild Cognitive Impairment: The Effect of Reducing the PiB‐PET Threshold
2019
Professor David Brooks
Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer’s disease
2019
Professor David Brooks
Attenuation of dopamine-induced GABA release in problem gamblers
2019
Dr Rory Durcan
Dr Lou Wiblin
Professor Lynn Rochester
Professor David Brooks
Professor David Burn
et al.
Clinical implications of early caudate dysfunction in Parkinson’s disease
2019
Professor David Brooks
Comment on "
In Vivo
[
18
F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates"
2019
Professor David Brooks
Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [
18
F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter
2019
Professor David Brooks
Dynamic
11
C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer’s disease and multiple sclerosis
2019
Professor David Brooks
Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: Study protocol for a randomised controlled trial (ELAD study)
2019
Rob Atkinson
Professor David Brooks
Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume
2019
Dr Rory Durcan
Dr Lou Wiblin
Dr Rachael Lawson
Dr Tien Kheng Khoo
Professor Alison Yarnall
et al.
Prevalence and duration of non‐motor symptoms in prodromal Parkinson's disease
2019
Professor David Brooks
Professor Nicola Pavese
Progressive loss of raphe nuclei serotonin transporter in early Parkinson’s disease: a longitudinal
123
I-FP-CIT SPECT study
2019
Professor David Brooks
Tau Aggregation Correlates with Amyloid Deposition in Both Mild Cognitive Impairment and Alzheimer's Disease Subjects
2019
Professor David Brooks
Widespread microglial activation in multiple system atrophy
2019
Professor David Brooks
Decreased noradrenaline transporter density in the motor cortex of Parkinson's disease patients
2018
Professor David Brooks
Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study
2018
Professor David Brooks
Evaluation of the noradrenergic system in Parkinson’s disease: an
11
C-MeNER PET and neuromelanin MRI study
2018
Professor David Brooks
Professor Nicola Pavese
Extrastriatal monoaminergic dysfunction and enhanced microglial activation in idiopathic rapid eye movement sleep behaviour disorder
2018
Professor David Brooks
In vivo quantification of glial activation in minipigs overexpressing human α-synuclein
2018
Professor Nicola Pavese
Professor David Brooks
In vivo staging of pathology in REM Sleep Behaviour Disorder – a multi-modality imaging case-control study
2018
Dr Michael Firbank
Dr Rachael Lawson
Professor Alison Yarnall
Professor David Brooks
Professor David Burn
et al.
Longitudinal diffusion tensor imaging changes in early Parkinson’s disease: ICICLE-PD study
2018
Professor David Brooks
MAO-B Inhibitors Do Not Block
In Vivo
Flortaucipir ([
18
F]-AV-1451) Binding
2018
Professor David Brooks
Microglial activation correlates
in vivo
with both tau and amyloid in Alzheimer’s disease
2018
Professor David Brooks
Nigrostriatal proteasome inhibition impairs dopamine neurotransmission and motor function in minipigs
2018
Professor David Brooks
Observations on REM sleep without atonia assessed with a semi-automated scoring algorithm
2018
Dr Dag Aarsland
Professor David Brooks
Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease
2018
Johann Pasquier
Professor David Brooks
Professor Nicola Pavese
Progression of tremor in early stages of Parkinson’s disease: a clinical and neuroimaging study
2018
Professor David Brooks
Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting
2018
Professor David Brooks
Role of neuroinflammation in Alzheimer’s trajectory and
in vivo
quantification using PET
2018
Professor David Brooks
Simplifying [
18
F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?
2018
Professor David Brooks
Simplifying [
18
F]GE-179 PET: are both arterial blood sampling and 90-minute acquisitions essential?
2018
Professor David Brooks
The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer’s Disease
2018
Professor David Brooks
The future of brain imaging in Parkinson’s disease
2018
Professor David Brooks
Professor Nicola Pavese
Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: A case-control study
2017
Professor Nicola Pavese
Professor David Brooks
Brain inflammation accompanies amyloid in a majority of mild cognitive impairment cases due to Alzheimer’s disease
2017
Dr Michael Firbank
Professor Alison Yarnall
Dr Rachael Lawson
Dr Gordon Duncan
Dr Tien Kheng Khoo
et al.
Cerebral glucose metabolism and cognition in newly diagnosed Parkinson’s disease: ICICLE-PD study
2017
Professor David Brooks
In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography
2017
Dr Luis Peraza Rodriguez
Dr Rachael Lawson
Dr Gordon Duncan
Professor Alison Yarnall
Dr Michael Firbank
et al.
Intra- and inter-network functional alterations in Parkinson's disease with mild cognitive impairment
2017
Dr Michael Firbank
Dr Rachael Lawson
Professor Alison Yarnall
Dr Gordon Duncan
Dr Tien Kheng Khoo
et al.
Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease
2017
Professor David Burn
Professor David Brooks
Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy
2017
Professor David Brooks
Suspected non Alzheimer's pathology – Is it non-Alzheimer's or non-amyloid?
2017
Professor Nicola Pavese
Professor David Brooks
Sustained striatal dopamine levels following intestinal levodopa infusions in Parkinson's disease patients
2017
Professor David Brooks
Validation of an electronic image reader training programme for interpretation of [
18
F]flutemetamol β-amyloid PET brain images
2017
Professor David Brooks
In vivo
imaging of neuromelanin in Parkinson's disease using
18
F-AV-1451 PET
2016
Dr Gordon Duncan
Dr Michael Firbank
Professor Alison Yarnall
Dr Tien Kheng Khoo
Professor David Brooks
et al.
Gray and white matter imaging: A biomarker for cognitive impairment in early Parkinson's disease?
2016
Professor David Burn
Professor David Brooks
Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease
2016
Professor David Brooks
Imaging Synucleinopathies
2016
Professor David Brooks
Imaging Systemic Dysfunction in Parkinson's Disease
2016
Professor David Brooks
Molecular imaging of dopamine transporters
2016
Dr Luis Peraza Rodriguez
Dr Rachael Lawson
Dr Michael Firbank
Professor Alison Yarnall
Professor David Brooks
et al.
Principal component discriminant analysis of mild cognitive impairment in Parkinson’s disease reveals early functional changes in the resting state
2016
Professor David Brooks
Professor Nicola Pavese
Sleep problems and hypothalamic dopamine D3 receptor availability in Parkinson disease
2016
Professor Alison Yarnall
Dr Rachael Lawson
Dr Gordon Duncan
Dr Tien Kheng Khoo
Professor David Brooks
et al.
Anticholinergic Load: Is there a Cognitive Cost in Early Parkinson's Disease?
2015
Dr Michael Firbank
Dr Rachael Lawson
Professor Alison Yarnall
Dr Tien Kheng Khoo
Professor David Brooks
et al.
Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study
2015
Dr Rachael Lawson
Professor Alison Yarnall
Dr Tien Kheng Khoo
Professor David Brooks
Professor David Burn
et al.
Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study
2015
Professor Alison Yarnall
Dr Gordon Duncan
Dr Shirley Coleman
Dr Michael Firbank
Professor Gavin Hudson
et al.
Characterizing mild cognitive impairment in incident Parkinson disease The ICICLE-PD Study
2014
Dr Gordon Duncan
Dr Tien Khoo
Professor Alison Yarnall
Dr Michael Firbank
Professor Patrick Chinnery
et al.
Genetic impact on cognition and brain function in newly diagnosed Parkinson's disease: ICICLE-PD study
2014
Dr Tien Khoo
Professor Alison Yarnall
Dr Gordon Duncan
Dr Shirley Coleman
Professor John O'Brien
et al.
The spectrum of nonmotor symptoms in early Parkinson disease
2013
Professor Alison Yarnall
Dr Tien Khoo
Dr Gordon Duncan
Professor David Brooks
Professor David Burn
et al.
Anti-cholinergic load: Is there a cognitive cost in early Parkinson’s disease?
2012
Dr Tien Kheng Khoo
Dr Gordon Duncan
Professor Alison Yarnall
Professor David Brooks
Professor John O'Brien
et al.
Apathy in incident Parkinson’s disease
2012
Professor Alison Yarnall
Professor Lynn Rochester
Dr Gordon Duncan
Dr Tien Kheng Khoo
Professor David Brooks
et al.
Cholinergic dysfunction in Parkinson’s disease with mild cognitive impairment: a short latency afferent inhibition study
2012
Dr Gordon Duncan
Dr Tien Kheng Khoo
Professor Alison Yarnall
Professor John O'Brien
Professor David Brooks
et al.
Elevated homocysteine levels and cognitive dysfunction in an incident cohort of non-demented Parkinson’s disease patients.
2012
Professor David Brooks
Professor David Burn
Updated guidelines for the management of Parkinson's disease
2001