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Lookup NU author(s): Professor David BrooksORCiD
This is the authors' accepted manuscript of a review published in its final definitive form in 2018. For re-use rights please refer to the publishers terms and conditions.
Recent evidence suggests that neuroinflammation and immunity play a significant role in Alzheimer’s disease (AD) and other neurodegenerative diseases. It has also been observed that, independent of the presence of aggregated proteins, neuroinflammation could be present in different neurodegenerative diseases. It has also been suggested that neuroinflammation could occur well ahead of amyloid deposition in AD. Recent genetic studies and other preclinical studies specifically point to a role of neuroinflammation and, in this review, we evaluate the evidence of neuroinflammation in the Alzheimer’s disease trajectory and the different imaging modalities by which we could monitor neuroinflammation in vivo in humans.
Author(s): Edison P, Brooks DJ
Publication type: Review
Publication status: Published
Journal: Journal of Alzheimer's Disease
Year: 2018
Volume: 64
Issue: s1
Pages: S339-S351
Print publication date: 12/06/2018
Online publication date: 26/05/2018
Acceptance date: 05/02/2018
ISSN (print): 1387-2877
ISSN (electronic): 1875-8908
URL: https://doi.org/10.3233/JAD-179929
DOI: 10.3233/JAD-179929
