Browse by author
Lookup NU author(s): Professor David BrooksORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Introduction The NMDA receptor radiotracer [18F]GE-179 has been used with 90-minute scans and arterial plasma input functions. We explored whether 1) arterial blood sampling is avoidable; and 2) shorter scans are feasible. Methods For 20 existing [18F]GE-179 datasets we generated: 1) standardised uptake values (SUVs) over eight intervals; 2) volume of distribution (VT) images using population-based input functions (PBIFs), scaled using one parent plasma sample; 3) VT images using three shortened datasets, using the original parent plasma input functions (ppIFs)Results Correlations with the original ppIF-derived 90-minute VTs increased for later interval SUVs (maximal ρ=0.78; 80–90 minutes). They were strong for PBIF-derived VTs (ρ=0.90), but between-subject coefficient of variation increased. Correlations were very strong for the 60/70/80 minute original ppIF-derived VTs (ρ=0.97–1.00), which suffered regionally variant negative bias. Conclusions Where arterial blood sampling is available, reduction of scan duration to 60 minutes is feasible, but with negative bias. The performance of SUVs was more consistent across participants than PBIF-derived VTs.
Author(s): McGinnity CJ, Riaño Barros DA, Trigg W, Brooks DJ, Hinz R, Duncan J, Koepp MJ, Hammers A
Publication type: Article
Publication status: Published
Journal: EJNMMI Research
Year: 2018
Volume: 8
Online publication date: 11/06/2018
Acceptance date: 08/05/2018
Date deposited: 09/05/2018
ISSN (electronic): 2191-219X
Publisher: SpringerOpen
URL: https://doi.org/10.1186/s13550-018-0396-2
DOI: 10.1186/s13550-018-0396-2
Altmetrics provided by Altmetric