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Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers

Lookup NU author(s): Professor David BrooksORCiD, Professor Nicola PaveseORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

Neuroinflammation (microglial activation) and subclinical nigrostriatal dysfunction have been reported in subjects at risk of parkinsonism. Eight non-manifesting carriers (NMCs) of LRRK2 G2019S mutation, had ¹¹C-PK11195 and ¹⁸F-DOPA PET to assess microglial activation and striatal dopamine system integrity, respectively. Comparisons were made with healthy controls. Five LRRK2-NMCs had subclinical reductions of putaminal ¹⁸F-DOPA uptake. Three of them had significantly raised nigral ¹¹C-PK11195 binding bilaterally. These findings indicate that nigrostriatal dysfunction and neuroinflammation occur in LRRK2-NMCs. Studies in larger cohorts with appropriate follow-up are needed to elucidate the significance of neuroinflammation in the premotor phase of LRRK2-PD.

Publication metadata

Author(s): Stokholm MG, Garrido A, Tolosa E, Serradell M, Iranzo A, Østergaard K, Borghammer P, Møller A, Parbo P, Stær K, Brooks DJ, Martí MJ, Pavese N

Publication type: Article

Publication status: Published

Journal: Journal of Neurology

Year: 2020

Volume: 267

Pages: 2296-2300

Print publication date: 01/08/2020

Online publication date: 21/04/2020

Acceptance date: 08/04/2020

Date deposited: 10/04/2020

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X

Publisher: Lippincott Williams & Wilkins

URL: https://doi.org/10.1007/s00415-020-09830-3

DOI: 10.1007/s00415-020-09830-3

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