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Lookup NU author(s): Professor Nicola PaveseORCiD, Professor David BrooksORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Background: Patients with Lewy body diseases exhibit various degrees of cortical and subcortical hypometabolism. However, the underlying causes behind this progressive hypometabolism remain unresolved. Generalized synaptic degeneration may be one key contributor. Objective: The objective of this study was to investigate whether local cortical synaptic loss is proportionally linked to the magnitude of hypometabolism in Lewy body disease. Method: Using in vivo PET we investigated cerebral glucose metabolism and quantified the density of cerebral synapses, as measured with [18F]FDG PET and [11C]UCB-J, respectively. Volumes-of-interest were defined on MR T1 scans and regional SUVR-1 values were obtained for 14 pre-selected brain regions. Between-group comparisons were conducted at voxel-level. Results: We observed regional differences in both synaptic density and cerebral glucose consumption in our cohorts of non-demented and demented patients with Parkinson’s disease or Dementia with Lewy bodies compared to healthy subjects. Additionally, voxel-wise comparisons showed a clear difference in cortical regions between demented patients and controls for both tracers. Importantly, our findings showed that the magnitude of reduced glucose uptake exceeded the magnitude of reduced cortical synaptic density. Conclusion: Here, we investigated the relationship between in vivo glucose uptake and the magnitude of synaptic density as measured using [18F]FDG PET and [11C]UCB-J PET in Lewy body patients. The magnitude of reduced [18F]FDG uptake was greater than the corresponding decline in [11C]UCB-J binding. Thus, the progressive hypometabolism seen in Lewy body disorders cannot be fully explained by generalized synaptic degeneration.
Author(s): Andersen KB, Hansen AK, Schacht AC, Horsager J, Gottrup H, Klit H, Danielsen EH, Pavese N, Brooks DJ, Borghammer P
Publication type: Article
Publication status: Published
Journal: Movement Disorders
Year: 2023
Volume: 38
Issue: 5
Pages: 796-805
Print publication date: 01/05/2023
Online publication date: 11/03/2023
Acceptance date: 16/02/2023
Date deposited: 16/02/2023
ISSN (print): 0885-3185
ISSN (electronic): 1531-8257
Publisher: John Wiley & Sons, Inc.
URL: https://doi.org/10.1002/mds.29375
DOI: 10.1002/mds.29375
ePrints DOI: 10.57711/5s9b-3519
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