Publications by Professor Laura Greaves - ePrints

Browsing publications by Professor Laura Greaves.

Newcastle Authors	Title	Year
George Kelly Dr Tetsushi Kataura Dr Johan Panek Hanna Salmonowicz Hannah Kendall et al.	Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule	2024
Hanna Salmonowicz Dr James Chapman George Kelly Professor Laura Greaves Professor Derek Mann et al.	Apoptotic stress causes mtDNA release during senescence and drives the SASP	2023
Dr Julia Whitehall Anna Smith Professor Laura Greaves	Mitochondrial DNA Mutations and Ageing	2023
Dr Ashwin Sachdeva Dr Christopher Carey Dr Amy Vincent Professor Laura Greaves Professor Rakesh Heer et al.	Automated quantitative high‑throughput multiplex immunofuorescence pipeline to evaluate OXPHOS defects in formalin‑fxed human prostate tissue	2022
Xuefei Yu Dr Catherine Arden Dr Rolando Berlinguer Palmini Dr Chun Chen Carla Bradshaw et al.	Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation	2022
Anna Smith Dr Julia Whitehall Professor Laura Greaves	Mitochondrial DNA mutations in ageing and cancer	2022
Dr Craig Stamp Dr Julia Whitehall Anna Smith Dr David Houghton Carla Bradshaw et al.	Age-associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon	2021
Amy Fuller Dr Nduka Okwose Jadine Scragg Professor Christopher Eggett Peter Luke et al.	The effect of age on mechanisms of exercise tolerance: Reduced arteriovenous oxygen difference causes lower oxygen consumption in older people	2021
Dr Julia Whitehall Professor Laura Greaves	Aberrant mitochondrial function in ageing and cancer	2020
Anna Smith Dr Julia Whitehall Carla Bradshaw Dr Fiona Robertson Dr Alasdair Blain et al.	Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis	2020
Dr Philip Dobson Dr Ella Dennis Dan Hipps Dr Amy Reeve Dr Alex Laude et al.	Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss	2020
Dr Conor Lawless Professor Laura Greaves Dr Amy Reeve Emeritus Professor Doug Turnbull Dr Amy Vincent et al.	The rise and rise of mitochondrial DNA mutations	2020
Dr Hannah Paish Lee Reed Helen Brown Mark Bryan Dr Olivier Govaere et al.	A bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices	2019
Dr Fiona Malcomson Dr Stella Breininger Khalil ElGendy Aj Joel Thilanka Ranathunga et al.	Design and baseline characteristics of the Biomarkers Of Risk In Colorectal Cancer (BORICC) Follow-Up study: A 12+ years follow-up	2019
Dr Stella Breininger Dr Fiona Malcomson Dr Sonny Afshar Emeritus Professor Doug Turnbull Professor Laura Greaves et al.	Effects of obesity and weight loss on mitochondrial structure and function and implications for colorectal cancer risk	2019
Rhys Anderson Anthony Lagnado Damien Maggiorani Dr Anna Walaszczyk Emily Dookun et al.	Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence	2019
Professor Laura Greaves Professor Robert Taylor Dr Jim Stewart	A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency	2018
Dr Dave Houghton Professor Christopher Stewart Dr Craig Stamp Professor Anil Wipat Professor Mike Trenell et al.	Age-related mitochondrial dysfunction influences the mouse intestinal microbiome composition	2018
Tianhong Su Dr John Grady Sorena Afshar Professor Robert Taylor Emeritus Professor Doug Turnbull et al.	Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations	2018
Dr Craig Stamp Dr Anze Zupanic Ashwin Sachdeva Dr Elizabeth Stoll Dr Daryl Shanley et al.	Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts	2018
Tianhong Su Emeritus Professor Doug Turnbull Professor Laura Greaves	Roles of mitochondrial DNA mutations in stem cell ageing	2018
Dr Dave Houghton Professor Christopher Stewart Dr Craig Stamp Professor Anil Wipat Professor Mike Trenell et al.	Impact of Age-Related Mitochondrial Dysfunction and Exercise on Intestinal Microbiota Composition	2017
Alex Bury Dr Angela Pyle Dr Joanna Elson Professor Laura Greaves Dr Christopher Morris et al.	Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson disease	2017
Dr Mohammad Moad Laura Wilson Rob Pickard Emeritus Professor Doug Turnbull Professor Robert Taylor et al.	Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates	2017
Holly Baines Dr Craig Stamp Professor Laura Greaves Dr Jim Stewart	A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease	2016
Ashwin Sachdeva Dr Amira El-Sherif Emeritus Professor Doug Turnbull Professor Laura Greaves Professor Rakesh Heer et al.	Development of prostate intra-epithelial neoplasia in an aging series of PolgA mutator mice suggests a role for mitochondrial DNA mutations in prostate carcinogenesis	2016
Dr Ellen Tullo Professor Laura Greaves Dr Luisa Wakeling	Involving older people in the design, development, and delivery of an innovative module on aging for undergraduate students	2016
Dr Clara Correia Melo Francisco Marques Rhys Anderson Dr Graeme Hewitt Dr Bernadette Carroll et al.	Mitochondria are required for pro-ageing features of the senescent phenotype	2016
Dr Philip Dobson Dr Mariana Rocha Dr John Grady Alexia Chrysostomou Sharon Watson et al.	Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA^-/^-mice	2016
Professor Grainne Gorman Dr Hue Hornig - Do Dr Helen Tuppen Professor Laura Greaves Dr Langping He et al.	Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression	2015
Professor Laura Greaves Dr Anne Grunewald	SCNT-Derived ESCs with Mismatched Mitochondria Trigger an Immune Response in Allogeneic Hosts	2015
Dr Joanna Elson Dr Paul Smith Professor Laura Greaves Professor Robert Lightowlers Professor Zofia Chrzanowska-Lightowlers et al.	The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease	2015
Professor Laura Greaves Professor Robert Taylor	Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy	2014
Dr Diana Jurk Dr Caroline Wilson Dr Joao Passos Professor Fiona Oakley Clara Correia Melo et al.	Chronic inflammation induces telomere dysfunction and accelerates ageing in mice	2014
Professor Laura Greaves Marco Nooteboom Dr Joanna Elson Dr Helen Tuppen Geoffrey Taylor et al.	Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing	2014
Dr Stuart Williamson Laura Wilson Graeme Williamson Professor Laura Greaves Dr Helen Tuppen et al.	Finding a niche. The location of human prostate stem cells	2014
Holly Baines Emeritus Professor Doug Turnbull Professor Laura Greaves	Human stem cell aging: do mitochondrial DNA mutations have a causal role?	2014
Holly Baines Dr Jim Stewart Craig Stamp Dr Anze Zupanic Emeritus Professor Thomas Kirkwood et al.	Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans	2014
Dr Paul Smith Dr Joanna Elson Professor Laura Greaves Professor Robert Lightowlers Professor Zofia Chrzanowska-Lightowlers et al.	The role of the mitochondrial ribosome in human disease: Searching for mutations in 12S mitochondrial rRNA with high disruptive potential	2013
Professor Laura Greaves Dr Joanna Elson Dr John Grady Geoffrey Taylor Professor Robert Taylor et al.	Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations	2012
Dr John Blackwood Professor Laura Greaves Laura Wilson Rob Pickard Professor Majlinda Lako et al.	Lineage tracking in situ: Where are the prostate stem cells? What are they doing?	2012
Professor Laura Greaves Dr Amy Reeve Professor Robert Taylor Emeritus Professor Doug Turnbull	Mitochondrial DNA and disease	2012
Dr John Blackwood Dr Stuart Williamson Professor Laura Greaves Laura Wilson Dr Anastasia Hepburn et al.	In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells	2011
Professor Laura Greaves Dr Martin Barron Emeritus Professor Thomas Kirkwood Emeritus Professor Doug Turnbull	Differences in the accumulation of mitochondrial defects with age in mice and humans	2011
Marco Nooteboom Professor Robert Taylor Professor Robert Lightowlers Emeritus Professor Thomas Kirkwood Professor John Mathers et al.	Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts	2010
Professor Laura Greaves Dr Martin Barron Dr Stefan Plusa Emeritus Professor Thomas Kirkwood Professor John Mathers et al.	Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts	2010
Professor Laura Greaves Dr Martin Barron Dr Stefan Plusa Emeritus Professor Thomas Kirkwood Professor John Mathers et al.	Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts	2010
Professor Laura Greaves Dr Patrick Yu Wai Man Kim Krishnan Nina Beadle Dr Martin Barron et al.	Mitochondrial DNA Defects and Selective Extraocular Muscle Involvement in CPEO	2010
Dr Patrick Yu Wai Man Dr Gillian Borthwick Dr Langping He Geoffrey Taylor Professor Laura Greaves et al.	Somatic Mitochondrial DNA Deletions Accumulate to High Levels in Aging Human Extraocular Muscles	2010
Dr Nimantha De Alwis Emeritus Professor Doug Turnbull Professor Robert Taylor Professor Laura Greaves Professor Patrick Chinnery et al.	A Methodological Approach to Tracing Cell Lineage in Human Epithelial Tissues	2009
Dr Don Mahad Dr Iryna Ziabreva Graham Campbell Dr Julie Murphy Dr Amy Reeve et al.	Detection of cytochrome c oxidase activity and mitochondrial proteins in single cells	2009
Emeritus Professor Doug Turnbull Professor Robert Taylor Professor Laura Greaves Professor Patrick Chinnery	Locating the Stem Cell Niche and Tracing Hepatocyte Lineages in Human Liver	2009
Professor Laura Greaves Emeritus Professor Doug Turnbull	Mitochondrial DNA mutations and ageing	2009
Professor Laura Greaves Professor John Mathers Professor Robert Taylor Emeritus Professor Doug Turnbull	Modelling mitochondrial DNA mutations in bacterial cytochrome c oxidase: Link to colon cancer?	2009
Professor Laura Greaves Nina Beadle Geoffrey Taylor Dr Daniel Commane Professor John Mathers et al.	Quantification of mitochondrial DNA mutation load	2009
Professor Robert Taylor Professor Laura Greaves Dr Martin Barron Philip Griffiths Emeritus Professor Doug Turnbull et al.	A histochemical and molecular genetic investigation of the selective, extraocular muscle involvement in chronic progressive external ophthalmoplegia	2008
Professor Laura Greaves Professor Robert Taylor Emeritus Professor Doug Turnbull	Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells	2008
Professor Laura Greaves Dr Amy Reeve Emeritus Professor Doug Turnbull	Mitochondrial DNA mutations and aging	2007
Professor Laura Greaves Dr Amy Reeve Emeritus Professor Doug Turnbull	Mitochondrial DNA mutations and aging	2007
Professor Laura Greaves Dr Daniel Commane Dr Hazel Greetham Professor Robert Taylor Emeritus Professor Doug Turnbull et al.	Novel preliminary findings of mitochondrial DNA mutations in colonic crypts of patients with diverticular disease (the Boricc study)	2007
Professor Laura Greaves Dr Amy Reeve Emeritus Professor Doug Turnbull	The ageing mitochondrial genome	2007
Professor Laura Greaves Emeritus Professor Doug Turnbull	Clonal expansion in the human gut - Mitochondrial DNA mutations show us the way	2006
Dr Simon Wilkinson Professor Laura Greaves Professor Faith Williams	Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies	2006
Dr Ramesh Arasaradnam Professor Laura Greaves Dr Daniel Commane Professor John Mathers Professor Robert Taylor et al.	Mitochondrial DNA (MTDNA) mutations in human colonic crypts: A novel biomarker of colorectal cancer.	2006
Professor Laura Greaves Professor Robert Taylor Dr Martin Barron Emeritus Professor Doug Turnbull	Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission	2006
Professor Laura Greaves Professor Robert Taylor	Mitochondrial DNA mutations in human disease	2006
Professor Laura Greaves Emeritus Professor Doug Turnbull	Modelling of the expansion of normal human colonic crypts	2006
Professor Laura Greaves Emeritus Professor Doug Turnbull	Clusters of phenotypically related human colonic crypts develop through crypt fission: Implications for colorectal carcinogenesis	2005
Professor Laura Greaves Emeritus Professor Doug Turnbull	Clusters of phenotypically-related human colonic crypts develop through crypt fission: Implications for colorectal carcinogenesis	2005
Professor Robert Taylor Dr Langping He Professor Laura Greaves Geoffrey Taylor Dr Martin Barron et al.	Mitochondrial DNA mutations in human colonic crypt stem cells	2004
Professor Laura Greaves Dr Martin Barron Professor Robert Taylor Emeritus Professor Doug Turnbull	Mitochondrial DNA mutations in human colonic crypt stem cells - implications for function	2004
Professor Robert Taylor Dr Martin Barron Dr Gillian Borthwick Professor Patrick Chinnery Dr David Samuels et al.	Mitochondrial DNA mutations and aging in human colonic crypts and stem cells	2003
Professor Robert Taylor Dr Martin Barron Dr Gillian Borthwick Professor Patrick Chinnery Dr David Samuels et al.	Mitochondrial DNA mutations in human colonic crypt stem cells	2003
Professor Laura Greaves Dr Simon Wilkinson Professor Faith Williams	Factors affecting percutaneous absorption of caffeine in vitro	2002