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Mitochondrial DNA mutations and aging

Lookup NU author(s): Professor Laura GreavesORCiD, Dr Amy Reeve, Emeritus Professor Doug Turnbull

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Abstract

Mitochondria have been hypothesized to play a role in both aging and neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease. Many studies have shown the accumulation of mitochondrial DNA (mtDNA) mutations in post-mitotic tissues and more recent data have shown this also to be a feature of aging mitotic tissues. Much of this data has been correlative, until recently with the development of polymerase gamma deficient mice which accumulate high levels of mtDNA mutations and show a premature aging phenotype, that a more causative role has been proposed. This article focuses on recent developments in aging research into the role that mtDNA mutations play in the aging process. © 2007 New York Academy of Sciences.


Publication metadata

Author(s): Krishnan KJ, Greaves LC, Reeve AK, Turnbull DM

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Biogerontology - Mechanisms and Interventions: 5th European Congress of Biogerontology

Year of Conference: 2007

Pages: 227-240

ISSN: 0077-8923

Publisher: Wiley-Blackwell Publishing, Inc.

URL: http://dx.doi.org/10.1196/annals.1395.024

DOI: 10.1196/annals.1395.024

PubMed id: 17460184

Library holdings: Search Newcastle University Library for this item

Series Title: Annals of the New York Academy of Sciences

ISBN: 1573316792


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