Publications by Professor David Young - ePrints

Browsing publications by Professor David Young.

Newcastle Authors	Title	Year
Dan Hayman Dr Francesca Johnson de Sousa Brito Hua Lin Yao Hao Rachel Pearson et al.	microRNA-324 mediates bone homeostasis and the regulation of osteoblast and osteoclast differentiation and activity	2025
Dr Jamie Soul Yao Hao Hua Lin Dr Katarzyna Pirog Dr Jonathan Coxhead et al.	Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis mouse models.	2024
Dr Francesca Johnson de Sousa Brito Rachel Pearson Professor David Young Dr Katarzyna Pirog	Role of Asporin in chondroprotection	2024
Dr Matthew Barter Dr Sarah Rice Hua Lin Dr Adrian Falconer Dr Jamie Soul et al.	SERPINA3 is a marker of cartilage differentiation and is essential for the expression of extracellular matrix genes during early chondrogenesis	2024
Dr Krutik Patel Dr Matthew Barter Dr Jamie Soul Dr Peter Clark Dr Carole Proctor et al.	Systems analysis of miR-199a/b-5p and multiple miR-199a/b-5p targets during chondrogenesis	2024
Professor David Young	The potential therapeutic applications of long noncoding RNAs	2024
Dr Matthew Barter Andrew Skelton Dr Carole Proctor Professor David Young	DNA methylation analysis identifies key transcription factors involved in mesenchymal stem cell osteogenic differentiation	2023
Dr Matthew Barter Andrew Butcher Dr Hui Wang Dr Dimitra Tsompani Dr Martin Galler et al.	HDAC6 regulates NF-κB signalling to control chondrocyte IL-1-induced MMP and inflammatory gene expression	2022
Professor David Young Yao Hao	Highly efficient CRISPR-Cas9-mediated editing identifies novel mechanosensitive microRNA-140 targets in primary human articular chondrocytes	2022
Professor David Young Dr Matthew Barter Dr Jamie Soul	Osteoarthritis year in review: genetics, genomics, epigenetics	2022
Krutik Patel Sharmilla Chandrasegaran Dr Carole Proctor Professor David Young Dr Daryl Shanley et al.	TimiRGeN: R/Bioconductor package for time series microRNA–mRNA integration and analysis	2021
Dr Matthew Barter Kat Cheung Julia Falk Dr Andreas Panagiotopoulos Professor Stephen O'Brien et al.	Dynamic chromatin accessibility landscape changes following interleukin-1 stimulation	2021
Thais De Las Heras Ruiz Marc Farcasanu Professor David Young Dr Katarzyna Pirog	Dynamic compression dramatically improves the chondrogenic potential of ATDC5 cells in the tissue engineered model of healthy and PSACH cartilage	2021
Dan Hayman Dr Tamara Modebadze Sarah Charlton Kat Cheung Dr Jamie Soul et al.	Increased hippocampal excitability in miR-324-null mice	2021
Dr David Wilkinson Dr Adrian Falconer Hua Lin Kat Cheung Sarah Charlton et al.	Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.	2021
Dr Jamie Soul Dr Matthew Barter Professor David Young	OATargets: A knowledge base of genes associated with osteoarthritis joint damage in animals	2021
Tania Jones Mohammed Esa SR Gokul Krishnan Professor Mark Pearce Professor David Young et al.	Osteoporosis, fracture, osteoarthritis & sarcopenia: A systematic review of circulating microRNA association	2021
Dr Jessica Tarn Sarah Charlton Andrew Skelton Dr Matthew Barter Professor David Young et al.	Regulation of microRNA-221, -222, -21 and -27 in articular cartilage subjected to abnormal compressive forces	2021
Dr Ella Dennis Robert Jackson Dr Dimitra Tsompani Professor David Young Dr Katarzyna Pirog et al.	CRELD2 is a novel LRP1 chaperone that regulates non-canonical WNT signalling in skeletal development	2020
Dr Matthew Barter Dr Catherine Bui Kat Cheung Julia Falk Dr Rodolfo Gomez et al.	DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions	2020
Kat Cheung Dr Matthew Barter Julia Falk Dr Carole Proctor Dr Louise Reynard et al.	Histone ChIP-Seq identifies differential enhancer usage during chondrogenesis as critical for defining cell-type specificity	2020
Dr Sarah Rice Professor David Young Professor John Loughlin	Interplay between genetics and epigenetics in osteoarthritis	2020
Jose Coelho Lima Junior Dr Ashfaq Mohammed Dr Suzanne Cormack Adnan Ali Dr Matthew Barter et al.	Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion	2020
Sam Charlton Kat Cheung Yao Hao Dr Jamie Soul Dr Louise Reynard et al.	microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs	2020
Dr Matthew Barter Professor David Young	The role of microRNA-3085 in chondrocyte function	2020
Kat Cheung Marjolein Burgers Professor David Young Dr Simon Cockell Dr Louise Reynard et al.	Correlation of Infinium HumanMethylation450K and MethylationEPIC BeadChip arrays in cartilage	2019
Bola Ajekigbe Kat Cheung Dr Yaobo Xu Andrew Skelton Dr Andreas Panagiotopoulos et al.	Identification of long non-coding RNAs expressed in knee and hip osteoarthritic cartilage	2019
Steven Woods Dr Matthew Barter Dr Hannah Elliott Catherine Syddall Dr Mark Birch et al.	miR-324-5p is up regulated in end-stage osteoarthritis and regulates Indian Hedgehog signalling by differing mechanisms in human and mouse	2019
Professor David Young Dr Matthew Barter Dr David Wilkinson	Recent advances in understanding the regulation of metalloproteinases	2019
Dr Matthew Barter Professor David Young	The function of microRNAs in cartilage and osteoarthritis	2019
Professor David Young	Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis	2017
Dr Matthew Barter Dr Rodolfo Gomez Kat Cheung Andrew Skelton Dr Yaobo Xu et al.	The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells	2017
Dr Matthew Barter Professor David Young	Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA	2016
Dr Matthew Barter Professor David Young	Identification and characteriszation of MIR-3085 in chondrocytes	2016
Professor David Young	Identification of serum snornas as biomarkers of musculoskeletal ageing and disease	2016
Dr Matthew Barter Kat Cheung Dr Yaobo Xu Andrew Skelton Professor David Young et al.	Long noncoding RNA ROCR is essential for chondrogenic differentiation of mesenchymal stem cells	2016
Dr Matthew Barter Professor David Young	MicroRNA-455 targets multiple genes in the WNT signalling pathway	2016
Dr Matthew Barter Professor David Young	MicroRNAs: the role of MicroRNAs in the pathogenesis, detection and treatment of OA	2016
Dr Matthew Barter Professor David Young	The microRNA-29 family in cartilage homeostasis and osteoarthritis	2016
Dr Dimitra Tsompani Dr Matthew Barter Professor David Young	The role of histone deacetylase 3 in chondrogenesis and osteoarthritis	2016
Professor David Young	The role of microRNAs in osteoarthritis and ageing-related functional decline in joint tissue homeostasis	2016
Dr Michael Rushton Professor David Young Professor John Loughlin Dr Louise Reynard	Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients	2015
Dr Michael Rushton Professor David Young Professor John Loughlin Dr Louise Reynard	Differential DNA methylation and expression of inflammatory and zinc transporter genes defines sub-groups of osteoarthritic hip patients	2015
Dr Matthew Barter Maria Tselepi Dr Rodolfo Gomez Steven Woods Dr Graham Smith et al.	Genome-wide microRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR-140-5p	2015
Dr Matthew Barter Professor David Young	Identification and characterisation of novel MicroRNAs in osteoarthritis	2015
Shereen Al-Ali Dr Simon Cockell Dr Jessica Tarn Dr Katherine James Sarah Bowman et al.	Identification of Whole Blood Gene Expression Signature in Primary Sjogren's Syndrome Associated Lymphoma	2015
Dr Matthew Barter Dr Rodolfo Gomez Dr Yaobo Xu Professor David Young	Long non-coding RNAs in chondrocyte development and cartilage	2015
Dr Michael Rushton Dr Louise Reynard Professor David Young Dr Colin Shepherd Dr Rebecca Darlay et al.	Methylation of cartilage DNA is a mediator of genetic risk at several OA susceptibility loci	2015
Dr Michael Rushton Dr Louise Reynard Professor David Young Dr Colin Shepherd Dr Fiona Gee et al.	Methylation quantitative trait locus (meQTL) analysis of osteoarthritis links epigenetics with genetic risk	2015
Dr Matthew Barter Professor David Young	The miR-29 family in osteoarthritis	2015
Dr Dimitra Tsompani Dr Matthew Barter Emeritus Professor Drew Rowan Professor David Young	The role of Histone Deacetylase 3 in chondrogenesis and osteoarthritis	2015
Harriet Purvis Dr Amy Anderson Professor David Young Professor John Isaacs Professor Catharien Hilkens et al.	A Negative Feedback Loop Mediated by STAT3 Limits Human Th17 Responses	2014
Dr Michael Rushton Dr Louise Reynard Dr Matthew Barter Dr Kenneth Rankin Professor David Young et al.	Characterisation of the cartilage DNA methylome in knee and hip osteoarthritis using high-density genome-wide analysis	2014
Dr Michael Rushton Dr Louise Reynard Dr Matthew Barter Ramsay Refaie Dr Kenneth Rankin et al.	Characterization of the cartilage DNA methylome in knee and hip osteoarthritis	2014
Dr Gary Litherland Martina Elias Dr David Wilkinson Sharon Watson Professor David Young et al.	Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis	2014
Shereen Al-Ali Dr Simon Cockell Andrew Skelton Dr Katherine James Dr Jessica Tarn et al.	Identification of Whole Blood Gene Expression Signature in Primary Sjogren's Syndrome Associated Lymphoma	2014
Dr Katherine James Dr Jessica Tarn Shereen Al-Ali Dr Jennifer Hallinan Professor David Young et al.	Integration of Gene Expression Data with Interaction and Annotation Data Reveals Patterns of Connection Between Primary Sjögren’s Syndrome Associated Genes and Immune Processes	2014
Professor David Young Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston Dr Carole Proctor	Investigating molecular mechanisms of ageing cartilage using computer simulation models	2014
Dr Matthew Barter Dr Yaobo Xu Professor David Young	Long non coding rnas in osteroarthritis and chondrogenesis	2014
Dr Matthew Barter Professor David Young	Methods for the identification of microRNA-455 targets	2014
Professor David Young Emeritus Professor Drew Rowan Xin Xu Emeritus Professor Tim Cawston Dr Carole Proctor et al.	Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage	2014
Dr Marta Radwan Dr David Wilkinson Dr Auriane Destrument Sarah Charlton Dr Matthew Barter et al.	Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination	2014
Dr Matthew Barter Professor David Young	The microRNA-29 family in osteoarthritis	2014
Emeritus Professor Tim Cawston Professor David Young Emeritus Professor Drew Rowan	Tissue destruction and repair	2014
Dr Jessica Tarn Dr Simon Cockell Dr Colin Gillespie Shereen Al-Ali Dr Katherine James et al.	Whole Blood microRNA Signature for Primary Sjogren's Syndrome-Related Lymphoma	2014
Dr Matthew Barter Professor David Young	Epigenetic Mechanisms and Non-coding RNAs in Osteoarthritis	2013
Dr Matthew Barter Professor David Young	Identification and characterisation of novel microRNAS ivolved in osteoarthritis	2013
Dr Marta Radwan Christos Gavriilidis Professor John Robinson Emeritus Professor Drew Rowan Professor David Young et al.	Matrix metalloproteinase-13 expression in response to double-stranded RNA in human chondrocytes	2013
Christos Gavriilidis Dr Satomi Miwa Professor Thomas von Zglinicki Professor Robert Taylor Professor David Young et al.	Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2	2013
Professor David Young	More evidence for a role of CpG methylation in the pathogenesis of osteoarthritis	2013
Catherine Syddall Dr Louise Reynard Professor David Young Professor John Loughlin	The Identification of Trans-acting Factors That Regulate the Expression of GDF5 via the Osteoarthritis Susceptibility SNP rs143383	2013
Dr Arthur Pratt Dr Daniel Swan Dr Sarah Richardson Gillian Wilson Professor Catharien Hilkens et al.	A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly anti-citrullinated peptide antibody-negative disease	2012
Dr Hui Wang Professor David Young Emeritus Professor Tim Cawston	Age-related knee joint cartilage changes in mice	2012
Dr Catherine Bui Dr Matthew Barter Jenny Scott Dr Martin Galler Dr Louise Reynard et al.	cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis	2012
Dr Hui Wang Professor David Young Emeritus Professor Tim Cawston	Cartilage degradation, expression of mmp-13 and oxidation markers increase with age in the knee joints of aged mice	2012
Yaobo Xu Dr Matthew Barter Dr Daniel Swan Dr Kenneth Rankin Emeritus Professor Drew Rowan et al.	Comparison of osteoarthritis and normal hip cartilage transcriptomes using RNA-seq reveals new candidate gene targets and associated pathways	2012
Dr Matthew Barter Dr Catherine Bui Professor David Young	Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs	2012
Dr Catherine Bui Dr Matthew Barter Professor David Young	Epigenetic regulation of the MMP13 promoter depends on a single CpG site demethylation in human articular chondrocytes	2012
Professor David Young Dr Matthew Barter Dr Catherine Bui	Epigenetics: marks for future OA research?	2012
Dr Matthew Barter Ellen Rumsby Andrew Butcher Professor David Young	Histone deacetylase 6 (HDAC6) is essential for chondrocyte NF-kappa B signalling and MMP expression	2012
Dr Hannah Elliott Dr Matthew Barter Professor David Young	Identification and characterisation of micrornas involved in chondrocyte differentiation and osteoarthritis	2012
Dr Matthew Barter Dr Daniel Swan Dr Kenneth Rankin Emeritus Professor Drew Rowan Dr Mauro Santibanez Koref et al.	Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA	2012
Yaobo Xu Dr Matthew Barter Dr Daniel Swan Dr Kenneth Rankin Emeritus Professor Drew Rowan et al.	Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA	2012
Dr Marta Radwan Emeritus Professor Drew Rowan Professor John Robinson Emeritus Professor Tim Cawston Professor David Young et al.	Involvement of pattern recognition receptors in poly(I:C)-mediated MMP-13 expression	2012
Dr Gary Litherland Madona Elias Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan Professor David Young et al.	Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases	2012
Christos Gavriilidis Professor Robert Taylor Professor David Young	Mitochondrial dysfunction and oxidative damage in osteoarthritis	2012
Dr Jessica Tarn Professor David Young Dr Dennis Lendrem Christine Downie Heather Foggo et al.	Serum cytokine and chemokine profiling in primary Sj ögren's syndrome Normal 0 false false false EN-GB X-NONE X-NONE	2012
Jessica Tarn Andini Natasari Sheryl Mitchell Dr Dennis Lendrem Christine Downie et al.	Soluble molecule profiling and network analysis of primary Sjogren's syndrome patient serum	2012
Dr Hannah Elliott Dr Matthew Barter Professor David Young	The expression and function of microRNAs in chondrogenesis and osteoarthritis	2012
Catherine Syddall Dr Louise Reynard Professor David Young Professor John Loughlin	The identification of the trans-acting factors that differentially regulate the expression of GDF5 via the OA associated SNP rs143383	2012
Catherine Syddall Dr Louise Reynard Professor David Young Professor John Loughlin	The identification of trans-acting factors that differentially regulate the expression of GDF5 via the osteoarthritis associated SNP RS143383	2012
Professor David Young Dr Catherine Bui Dr Matthew Barter	Understanding CpG methylation in the context of osteoarthritis	2012
Dr Arthur Pratt Dr Sarah Richardson Gillian Wilson Professor Catharien Hilkens Professor David Young et al.	A Transcriptional Profile Present in CD4+T-Cells of Patients with Undifferentiated Arthritis Predicts the Future Development of Seronegative Rheumatoid Arthritis and Implicates IL-6 in Disease Evolution	2011
Dr Louise Reynard Dr Catherine Bui Professor David Young Professor John Loughlin	Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation	2011
Steven Woods Dr Matthew Barter Helen Elliott Catherine Syddall Dr Mark Birch et al.	miR324-5p in osteoarthritis and indian hedgehog signalling	2011
Catherine Syddall Dr Mark Birch Professor David Young	miR324-5p is increased in end-stage osteoarthritic cartilage and regulates hedgehog signalling	2011
Dr Marta Radwan Emeritus Professor Drew Rowan Professor John Robinson Emeritus Professor Tim Cawston Professor David Young et al.	Pattern recognition receptors in osteoarthritic cartilage	2011
Professor David Young	Differential Gene Expression Profiling of Metalloproteinases and Their Inhibitors A Comparison Between Bovine Intervertebral Disc Nucleus Pulposus Cells and Articular Chondrocytes	2010
Dr Matthew Barter Leon Pybus Dr Gary Litherland Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	HDAC-mediated control of ERK- and PI3K-dependent TGF-beta-induced extracellular matrix-regulating genes	2010
Professor David Young	Identification and characterisation of micrornas involved in chondrocyte differentiation and osteoarthritis	2010
Dr Hui Wang Emeritus Professor Tim Cawston Dr Gary Litherland Madona Elias Emeritus Professor Drew Rowan et al.	Leptin produced by joint white adipose tissue induces cartilage degradation by up-regulation and activation of matrix metalloproteinases	2010
Dr Matthew Barter Dr Rachel Lakey Dr Jonathan Catterall Emeritus Professor Tim Cawston Professor David Young et al.	Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation	2010
Dr Gary Litherland Dr Matthew Jefferson Dr Matthew Barter Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway	2010
Dr Jenny Milner Amit Patel Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis	2010
Dr Jenny Milner Amit Patel Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis	2010
Dr Jenny Milner Amit Patel Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Matriptase is a novel initiator of cartilage matrix resorptionm in osteoarthritis	2010
Steven Woods Catherine Syddall Dr Mark Birch Professor David Young	miR324-5p is increased in end-stage osteoarthritic cartilage and regulates hedgehog signalling	2010
Professor David Young	MMP28 gene expression is regulated by Sp1 transcription factor acetylation	2010
Dr Arthur Pratt Dr Daniel Swan Dr Sarah Richardson Professor Catharien Hilkens Professor David Young et al.	Peripheral Blood CD4 T Cell Gene Expression Profiles as Predictive Biomarkers in Early Arthritis	2010
Emeritus Professor Tim Cawston Professor David Young	Proteinases involved in matrix turnover during cartilage and bone breakdown	2010
Jenny Scott Professor Robert Taylor Professor David Young	Superoxide dismutase 2 downregulation and mitochondria respiration in osteoarthritis	2010
Jenny Scott Christos Gavriilidis Emeritus Professor Thomas Kirkwood Professor Robert Taylor Professor David Young et al.	Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease	2010
Dr Arthur Pratt Dr Daniel Swan Professor David Young Professor Catharien Hilkens Professor John Isaacs et al.	A High-Throughput Transcriptomics Approach to Biomarker Discover in Early Arthritis	2009
Emeritus Professor Thomas Kirkwood Professor David Young	Investigating superoxide dismutase expression in cartilage and a potential role in osteoarthritis	2009
Professor David Young Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Lithium inhibits cartilage degradation and MMP production induced by pro-inflammatory cytokines	2009
Dr Min Hong Professor Andrew Gennery Professor Andrew Cant Dr Mario Abinun Professor David Young et al.	Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy	2009
Professor David Young	Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes	2008
Dr Gary Litherland Dr Matthew Barter Emeritus Professor Tim Cawston Professor John Robinson Emeritus Professor Drew Rowan et al.	Differential Toll-like receptor-dependent collagenase expression in chondrocytes	2008
Emeritus Professor Thomas Kirkwood Professor David Young	Epigenetic regulation of metalloproteinases and inhibitors in osteoarthritis	2008
Dr Gary Litherland Dr Craig Dixon Dr Rachel Lakey Tim Robson David Jones et al.	Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent	2008
Professor David Young	Acetylation in the regulation of metalloproteinase and tissue inhibitor of metalloproteinases gene expression	2007
Professor David Young	Acetylation regulates expression of the MMP28 gene	2007
Emeritus Professor Drew Rowan Professor David Young	Collagenase gene regulation by pro-inflammatory cytokines in cartilage	2007
Emeritus Professor Tim Cawston Emeritus Professor Thomas Kirkwood Professor David Young	Investigating SOD2 gene expression and regulation in osteoarthritic cartilage	2007
Dr Matthew Barter Emeritus Professor Tim Cawston Professor David Young	Downregulation of ADAM12 expression by histone deacetylase inhibitors	2006
Dr Jenny Milner Professor David Young David Jones Dr Emma Barksby Dr Angela Patterson et al.	Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis	2006
Dr Jenny Milner Professor David Jones Professor David Young Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis	2006
Dr Jenny Milner Professor David Young David Jones Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	Fibroblast-activation protein-alpha is expressed by chondrocytes following a proinflammatory stimulus and is elevated in osteoarthritis	2006
Emeritus Professor Tim Cawston Professor David Young	Inhibition of proteolytic activity involved in cartilage breakdown	2006
Dr Jenny Milner Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston Professor David Young	Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis	2006
Professor David Young	Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling	2006
Professor David Young Emeritus Professor Tim Cawston	Acetylation in the control of metalloproteinase expression	2005
Professor David Young	Differential effects of histone deacetylase inhibitors on phorbol ester- and TGFbeta- 1 induced Timp-1 gene expression	2005
Professor David Young	Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-β1 induced murine tissue inhibitor of metalloproteinases-1 gene expression	2005
Professor David Young Dr Rachel Lakey David Jones Emeritus Professor Tim Cawston	Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption	2005
Professor David Young Dr Rachel Lakey Professor David Jones Emeritus Professor Tim Cawston	Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption	2005
Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	OM in combination with TNFalpha induces a chondrocyte membrane associated aggrecanase	2005
Dr Emma Barksby Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	Oncostatin M in combination with tumour necrosis factor alpha induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or-2	2005
Professor David Young Dr Rachel Lakey David Jones Emeritus Professor Tim Cawston	Oncostatin M in combination with tumour necrosis factor alpha induces a chondrocyte membrane-associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2	2005
Professor David Young	Analysis of cell signaling pathways involved in the expression of metalloproteinases and their inhibitors in fibroblasts	2004
Professor David Young	Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes	2004
Professor David Young	Expression Profiling of Metalloproteinases and Their Inhibitors in Cartilage	2004
Professor David Young Dr Rachel Lakey Emeritus Professor Tim Cawston	Histone deacetylase inhibitors are chondroprotective	2004
Professor David Young Emeritus Professor Drew Rowan	The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-β1	2003
Professor David Young	TIMP-1 enhancer sequence--real or bacterial?	2003
Professor David Young	An enhancer complex confers both high-level and cell-specific expression of the human type X collagen gene	2002
Professor David Young Emeritus Professor Drew Rowan	Cryptic promoter activity of pBLCAT3 induced by overexpression of AP1 factors	2002
Professor David Young	Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene	2002
Professor David Young	The human tissue inhibitor of metalloproteinases (TIMP)-1 gene contains repressive elements within the promoter and intron 1	2000
Professor David Young	Characterization of a gene encoding a single-subunit bacteriophage-type RNA polymerase from maize which is alternatively spliced	1998