Publications by Emeritus Professor Tim Cawston - ePrints

Browsing publications by Emeritus Professor Tim Cawston.

Newcastle Authors	Title	Year
Dr Carole Proctor Christopher Macdonald Dr Jenny Milner Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	A computer simulation approach for assessing therapeutic intervention points to prevent cytokine-induced cartilage breakdown	2014
Professor David Young Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston Dr Carole Proctor	Investigating molecular mechanisms of ageing cartilage using computer simulation models	2014
Professor David Young Emeritus Professor Drew Rowan Xin Xu Emeritus Professor Tim Cawston Dr Carole Proctor et al.	Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage	2014
Emeritus Professor Tim Cawston Professor David Young Emeritus Professor Drew Rowan	Tissue destruction and repair	2014
Dr Carole Proctor Christopher Macdonald Dr Jenny Milner Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	A computer simulation approach for testing possible interventions to ameliorate collagen release	2013
Dr Hui Wang Professor David Young Emeritus Professor Tim Cawston	Age-related knee joint cartilage changes in mice	2012
Mark Houseman Dr Kate Potter Nicola Marshall Dr Rachel Lakey Emeritus Professor Tim Cawston et al.	Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up	2012
Dr Hui Wang Professor David Young Emeritus Professor Tim Cawston	Cartilage degradation, expression of mmp-13 and oxidation markers increase with age in the knee joints of aged mice	2012
Dr Marta Radwan Emeritus Professor Drew Rowan Professor John Robinson Emeritus Professor Tim Cawston Professor David Young et al.	Involvement of pattern recognition receptors in poly(I:C)-mediated MMP-13 expression	2012
Dr Gary Litherland Madona Elias Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan Professor David Young et al.	Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases	2012
Dr Marta Radwan Emeritus Professor Drew Rowan Professor John Robinson Emeritus Professor Tim Cawston Professor David Young et al.	Pattern recognition receptors in osteoarthritic cartilage	2011
Emeritus Professor Tim Cawston Dr Rachel Lakey Emeritus Professor Drew Rowan	Assay of matrix metalloproteinases against matrix substrates	2010
Dr Matthew Barter Leon Pybus Dr Gary Litherland Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	HDAC-mediated control of ERK- and PI3K-dependent TGF-beta-induced extracellular matrix-regulating genes	2010
Dr Hui Wang Emeritus Professor Tim Cawston Dr Gary Litherland Madona Elias Emeritus Professor Drew Rowan et al.	Leptin produced by joint white adipose tissue induces cartilage degradation by up-regulation and activation of matrix metalloproteinases	2010
Dr Matthew Barter Dr Rachel Lakey Dr Jonathan Catterall Emeritus Professor Tim Cawston Professor David Young et al.	Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation	2010
Dr Gary Litherland Dr Matthew Jefferson Dr Matthew Barter Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway	2010
Dr Jenny Milner Amit Patel Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis	2010
Dr Jenny Milner Amit Patel Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis	2010
Dr Jenny Milner Amit Patel Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Matriptase is a novel initiator of cartilage matrix resorptionm in osteoarthritis	2010
Emeritus Professor Tim Cawston Professor David Young	Proteinases involved in matrix turnover during cartilage and bone breakdown	2010
Dr Rachel Lakey Emeritus Professor Drew Rowan Professor John Isaacs Emeritus Professor Tim Cawston Professor Catharien Hilkens et al.	A novel paradigm for dendritic cells as effectors of cartilage destruction	2009
Dr Ian Forrest Professor Christopher Ward Vicky Ryan Dr Gavin Johnson Dr James Lordan et al.	Bronchalveolar Lavage Neutrophilia and MMP-9 at 3 Months Post Lung Transplantation May Predict the Development of BOS	2009
Professor David Young Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Lithium inhibits cartilage degradation and MMP production induced by pro-inflammatory cytokines	2009
Emeritus Professor Tim Cawston	Measurement of activity of collagenolytic MMP and inhibitors of MMPs using radiolabeled collagen substrate	2009
Dr Rachel Lakey Emeritus Professor Tim Cawston	Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases	2009
Adillah Binti Yusof Dr Ian Forrest Therese Small Debra Jones Professor Andrew Fisher et al.	Azithromycin attenuates effects of lipopolysaccharide on lung allograft bronchial epithelial cells	2008
Dr Ian Forrest Dr Gavin Johnson Therese Small Professor Andrew Fisher Emeritus Professor Tim Cawston et al.	Azithromycin attenuates lipopolysaccharide-mediated release of interleukin-8 and GM-CSF from primary bronchial epithelial cells derived from stable lung transplant recipients	2008
Dr Steven Young-Min Emeritus Professor Tim Cawston Dr David Coady	Biomarkers in the prediction of radiographic progression in early rheumatoid arthritis: Comment on the article by Young-Min et al	2008
Dr Gary Litherland Dr Matthew Barter Emeritus Professor Tim Cawston Professor John Robinson Emeritus Professor Drew Rowan et al.	Differential Toll-like receptor-dependent collagenase expression in chondrocytes	2008
Emeritus Professor Mike Sir Michael Rawlins Dr Ian Forrest Therese Small Debra Jones Professor Andrew Fisher et al.	Simvastatin attenuates release of neutrophilic and remodeling factors from primary bronchial epithelial cells derived from stable lung transplant recipients	2008
Dr Ian Forrest Therese Small Professor Andrew Fisher Emeritus Professor Tim Cawston Professor Christopher Ward et al.	Simvastatin potentially decreases neutrophilic inflammation and remodelling in the transplanted airway	2008
Dr Gary Litherland Dr Craig Dixon Dr Rachel Lakey Tim Robson David Jones et al.	Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent	2008
Dr Heather Bigg Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Activity of matrix metalloproteinase-9 against native collagen types I and III	2007
Emeritus Professor Tim Cawston	Assessment of collagenase activity in cartilage	2007
Dr Steven Young-Min Emeritus Professor Tim Cawston Dr David Coady	Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers	2007
Dr Ian Forrest Professor Christopher Ward Debra Jones Professor Andrew Fisher Emeritus Professor Tim Cawston et al.	Effect of azithromycin on primary bronchial epithelial cells derived from stable lung allografts	2007
Emeritus Professor Tim Cawston Dr Rachel Lakey Debra Jones Dr Jonathan Catterall Emeritus Professor Robin Seymour et al.	Gingival fibroblasts grown from cyclosporin-treated patients show a reduced production of matrix metalloproteinase-1 (MMP-1) compared with normal gingival fibroblasts, and cyclosporin down-regulates the production of MMP-1 stimulated by pro-inflammatory cytokines	2007
Emeritus Professor Tim Cawston Emeritus Professor Thomas Kirkwood Professor David Young	Investigating SOD2 gene expression and regulation in osteoarthritic cartilage	2007
Emeritus Professor Tim Cawston Professor Fraser Birrell	Research in hand osteoarthritis: Time for reappraisal and demand for new strategies. An opinion paper	2007
Dr Nicholas Peake Emerita Professor Helen Foster Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	Assessment of the clinical significance of gelatinase activity in patients with juvenile idiopathic arthritis using quantitative protein substrate zymography	2006
Dr Jonathan Catterall Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M	2006
Dr Matthew Barter Emeritus Professor Tim Cawston Professor David Young	Downregulation of ADAM12 expression by histone deacetylase inhibitors	2006
Dr Jenny Milner Professor David Young David Jones Dr Emma Barksby Dr Angela Patterson et al.	Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis	2006
Dr Jenny Milner Professor David Jones Professor David Young Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis	2006
Dr Jenny Milner Professor David Young David Jones Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	Fibroblast-activation protein-alpha is expressed by chondrocytes following a proinflammatory stimulus and is elevated in osteoarthritis	2006
Dr Ian Forrest Professor Christopher Ward Dr Desmond Murphy David Jones Dr James Lordan et al.	Hepatocyte growth factor - A link between neutrophilic inflammation and BOS?	2006
Emeritus Professor Drew Rowan Professor David Deehan Emeritus Professor Tim Cawston	Human nasal cartilage responds to oncostatin M in combination with interleukin 1 or tumour necrosis factor alpha by the release of collagen fragments via collagenases	2006
Emeritus Professor Tim Cawston Professor David Young	Inhibition of proteolytic activity involved in cartilage breakdown	2006
Dr Emma Barksby Ilka Wappler Dr Heiko Peters Dr Jenny Milner Emeritus Professor Tim Cawston et al.	Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes - Implications for cartilage destruction and repair	2006
Dr Nicholas Peake Dr Andrea Myers Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston Emerita Professor Helen Foster et al.	Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor	2006
Dr Jonathan Catterall Dr Rachel Lakey Emeritus Professor Tim Cawston	Investigation into the potential chondroprotective effects of ciclosporin in arthritis	2006
Dr Emma Barksby Dr Jenny Milner Dr Angela Patterson Dr Nicholas Peake Tim Robson et al.	Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: Implications for cartilage degradation in arthritis	2006
Dr Jenny Milner Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston Professor David Young	Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis	2006
Dr Rachel Lakey Dr Jonathan Catterall Emeritus Professor Tim Cawston	Mevastatin and simvastatin block collagen release from bovine cartilage and downregulate MMP-13 from human articular chondrocytes	2006
Dr William Shingleton Debra Jones Xin Xu Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Retinoic acid and oncostatin M combine to promote cartilage degradation via matrix metalloproteinase-13 expression in bovine but not human chondrocytes	2006
Dr Heather Bigg Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	The mammalian chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation	2006
Professor Christopher Ward Dr Ian Forrest Professor David Jones Dr Gary Pritchard Rachel Stovold et al.	The phosphodiesterase type IV (PDE IV) inhibitor cilomilast decreases pro-inflammatory cytokine production from primary bronchial epithelial cells derived from lung transplant recipients	2006
Dr Desmond Murphy Professor Christopher Ward David Jones Rachel Stovold Professor Andrew Fisher et al.	The phosphodiesterase type IV inhibitor cilomilast decreases pro-inflammatory cytokine production from primary bronchial epithelial cells in lung transplantation patients	2006
Emeritus Professor Tim Cawston	Understanding the role of tissue degrading enzymes and their inhibitors in development and disease	2006
Professor David Young Emeritus Professor Tim Cawston	Acetylation in the control of metalloproteinase expression	2005
Dr Steven Young-Min Dr David Coady Emeritus Professor Tim Cawston	Are biochemical markers predictive of radiographic progression in early rheumatoid arthritis and do they perform better than traditional markers?	2005
Dr Nicholas Peake Emeritus Professor Drew Rowan Dr Andrea Myers Emeritus Professor Tim Cawston Emerita Professor Helen Foster et al.	Assessment of the clinical significance of MMP activity in juvenile idiopathic arthritis (JIA)	2005
Dr Nicholas Peake Emeritus Professor Drew Rowan Dr Andrea Myers Emeritus Professor Tim Cawston	Assessment of the clinical significance of MMPs in Juvenile Idiopathic Arthritis	2005
Dr Steven Young-Min Dr David Coady Sarah Charlton Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	Early rheumatoid arthritis patients with DR4 shared epitope alleles progress radiologically and have elevated levels of serum MMP-3, serum comp, urinary GLC-GAL-PYD and urinary collagen crosslinks	2005
Dr Ian Forrest Dr James Lordan Dr Gary Pritchard Professor David Jones Dr Helen Robertson et al.	Epithelial to mesenchymal transition in clinically stable lung transplant recipients	2005
Tina Xu Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Evaluation of chondrocyte micromass culture for the study of cartilage degradation	2005
Professor David Young Dr Rachel Lakey David Jones Emeritus Professor Tim Cawston	Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption	2005
Professor David Young Dr Rachel Lakey Professor David Jones Emeritus Professor Tim Cawston	Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption	2005
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Human nasal cartilage responds to oncostatin M in combination with interleukin 1 or tumour necrosis factor α by the release of collagen fragments via collagenases	2005
Dr Nicholas Peake Dr Andrea Myers Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston Emerita Professor Helen Foster et al.	IL-6 and the soluble receptor in paired juvenile idiopathic arthritis (JIA) serum and SF samples	2005
Dr Nicholas Peake Dr Andrea Myers Debra Jones Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study	2005
Dr Steven Young-Min Dr David Coady Emeritus Professor Tim Cawston	Longitudinal measurement of traditional observer and laboratory based markers enhances prediction of radiographic progression in early rheumatoid arthritis. patient based responses were of limited use	2005
Dr Jenny Milner Emeritus Professor Tim Cawston	Matrix metalloproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases	2005
Emeritus Professor Tim Cawston Dr Heather Bigg Dr Jenny Milner Dr Jonathan Catterall Dr Emma Barksby et al.	Mechanisms of cartilage matrix turnover: synergistic interactions of proinflammatory cytokines with oncostatin M in upregulating matrix metalloproteinases and ADAMTS metalloproteinases	2005
Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	OM in combination with TNFalpha induces a chondrocyte membrane associated aggrecanase	2005
Dr Emma Barksby Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	Oncostatin M in combination with tumour necrosis factor alpha induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or-2	2005
Professor David Young Dr Rachel Lakey David Jones Emeritus Professor Tim Cawston	Oncostatin M in combination with tumour necrosis factor alpha induces a chondrocyte membrane-associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2	2005
Professor Christopher Ward Dr Ian Forrest Dr Helen Robertson Emeritus Professor Tim Cawston Professor Andrew Fisher et al.	Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients	2005
Dr Ian Forrest Dr Desmond Murphy Professor Christopher Ward David Jones Professor Kate Gould et al.	Primary airway epithelial cell culture from lung transplant recipients	2005
Dr Steven Young-Min Emeritus Professor Tim Cawston	Serum MMP-3 levels fall following the initiation of methotrexate in patients with early rheumatoid arthritis	2005
Dr Steven Young-Min Emeritus Professor Drew Rowan Sarah Charlton Dr David Coady Emeritus Professor Tim Cawston et al.	The biallelic 1G/2G single nucleotide polymorphism at position-1607BP of the MMP-1 promoter is not associated with rheumatoid arthritis, does not significantly affect measured levels of serum MMP-1 and is not associated with increased radiographic destruction	2005
Professor David Deehan Emeritus Professor Tim Cawston	The biology of intergration of the anterior cruciate ligament	2005
Dr Steven Young-Min Emeritus Professor Tim Cawston	The dominant role of serum MMP-3 compared to serum MMP-1 and MMP-13 in the generation of breakdown products from joint tissues in patients with early rheumatoid arthritis	2005
Dr Ian Forrest Professor Christopher Ward Professor Andrew Fisher Emeritus Professor Tim Cawston Dr James Lordan et al.	The potential role of interleukin-17 in airway inflammation and remodelling in post-transplant obliterative bronchiolitis	2005
Dr Nicholas Peake Emeritus Professor Tim Cawston Emerita Professor Helen Foster	Use of quantitative enzyme zymography to analyse proteinase activity in juvenile idiopathic arthritis (JIA) serum and SF samples	2005
Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL	2004
Dr Ian Forrest Dr James Lordan Dr Helen Robertson Emeritus Professor Tim Cawston Professor John Dark et al.	Epithelial to mesenchymal transition in clinically stable lung transplantation	2004
Professor David Young Dr Rachel Lakey Emeritus Professor Tim Cawston	Histone deacetylase inhibitors are chondroprotective	2004
Dr Ian Forrest Professor Christopher Ward Emeritus Professor Tim Cawston Dr James Lordan	IL-17 stimulates IL-8 release in primary epithelial cell cultures derived from lung allografts	2004
Dr Andrea Myers Dr Rachel Lakey Emeritus Professor Tim Cawston Dr Lesley Kay	Serum MMP-1 and TIMP-1 levels are increased in patients with psoriatic arthritis and their siblings	2004
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model	2003
Dr Jonathan Catterall Emeritus Professor Tim Cawston	Assays of matrix metalloproteinases (MMPs) and MMP inhibitors: bioassays and immunoassays applicable to cell culture medium, serum and synovial fluid	2003
Emeritus Professor Tim Cawston Dr Jenny Milner Dr Jonathan Catterall Emeritus Professor Drew Rowan	Cytokine synergy, collagenases and cartilage collagen breakdown	2003
Emeritus Professor Tim Cawston Dr Jenny Milner Dr Jonathan Catterall Emeritus Professor Drew Rowan	Cytokine synergy, collagenases and cartilage collagen breakdown	2003
Dr Jonathan Catterall Emeritus Professor Tim Cawston	Drugs in development: bisphosphonates and metalloproteinase inhibitors	2003
Dr Jenny Milner Emeritus Professor Drew Rowan Dr Sarah Elliott Emeritus Professor Tim Cawston	Inhibition of furin-like enzymes blocks interleukin-1 alpha/oncostatin M-stimulated cartilage degradation	2003
Dr Steven Young-Min Emeritus Professor Tim Cawston Angela Grainger	Modified Larsen scoring of digitized radiographs in rheumatoid arthritis	2003
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Oncostatin M in combination with tumor necrosis factor alpha induces cartilage damage and matrix metalloproteinase expression in vitro and in vivo	2003
Emeritus Professor Tim Cawston Dr Hui Wang Dr Christopher Richards Emeritus Professor Drew Rowan	Synergistic interactions of proinflammatory cytokines with oncostatin M: implications for joint destruction	2003
Nicola Leadbetter Emeritus Professor Tim Cawston	The effects of cyclosporin on the collagenolytic activity of gingival fibroblasts	2003
Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	Transforming growth factor beta 1 and insulin-like growth factor 1 block collagen degradation induced by oncostatin M in combination with tumour necrosis factor alpha from bovine cartilage	2003
Dr Bijayeswar Vaidya Professor Simon Pearce Stephen Charlton Emeritus Professor Drew Rowan Professor Pat Kendall-Taylor et al.	An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies	2002
Dr Bijayeswar Vaidya Professor Simon Pearce Sarah Charlton Nicola Marshall Emeritus Professor Drew Rowan et al.	An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies	2002
Professor Christopher Ward Dr Gary Pritchard Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Co-localisation of MMP-9 with neutrophils in stable lung transplant recipients - A potential role in Bronchiolitis Obliterans	2002
Emeritus Professor Tim Cawston	Enzymes	2002
Paul Koshy Neil Henderson Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines	2002
Emeritus Professor Tim Cawston	Mechanisms of Joint Destruction and Therapeutic Approaches	2002
Paul Koshy Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M - A time-course study using real-time quantitative reverse transcription-polymerase chain reaction	2002
Nicola Leadbetter Emeritus Professor Tim Cawston	The role of soluble interleukin (IL)-6 receptor in mediating the effects of IL-6 on matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 expression by gingival fibroblasts	2002
Dr Jenny Milner Dr Sarah Elliott Emeritus Professor Tim Cawston	Activation of procollagenases is a key control point in cartilage collagen degradation: Interaction of serine and metalloproteinase pathways	2001
Emeritus Professor Tim Cawston Paul Koshy Emeritus Professor Drew Rowan	Assays of matrix metalloproteinases against matrix substrates	2001
Emeritus Professor Tim Cawston	Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis	2001
Dr Jenny Milner Dr Sarah Elliott Emeritus Professor Tim Cawston	Inhibition of the serine proteinase furin blocks interleukin 1 alpha (IL-1 alpha)/oncostatin M (OSM) stimulated cartilage collagen degradation	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1α	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Insulin-like growth factor-1 blocks the release of collagen fragments from bovine nasal cartilage stimulated by oncostatin M in combination with interleukin-1	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Interleukin 13 blocks the release of collagen from bovine nasal cartilage treated with proinflammatory cytokines	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Interleukin-13 blocks the release of collagen fragments from bovine nasal cartilage treated with proinflammatory cytokines by preventing pro-collagenase activation	2001
Dr Steven Young-Min Emeritus Professor Tim Cawston	Leader: markers of joint destruction: principles, problems and potential	2001
Dr Steven Young-Min Emeritus Professor Tim Cawston	Markers of joint destruction: principles, problems, and potential	2001
Emeritus Professor Tim Cawston Dr Severine Carrere Dr Jonathan Catterall Dr Richard Duggleby Suzanne Elliott et al.	Matrix metalloproteinases and TIMPs: properties and implications for the treatment of chronc pulmonary disease	2001
Emeritus Professor Tim Cawston Dr Severine Carrere Dr Jonathan Catterall Dr Richard Duggleby Suzanne Elliott et al.	Matrix metalloproteinases and TIMPs: Properties and implications for the treatment of chronic obstructive pulmonary disease	2001
Emeritus Professor Tim Cawston Dr Severine Carrere Dr Jonathan Catterall Dr Richard Duggleby Suzanne Elliott et al.	Matrix metalloproteinases and TIMPs: properties and implications for the treatment of chronic obstructive pulmonary disease	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by TGF-beta 1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-alpha	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by transforming growth factor-beta 1 and insulin-like growth factor-1 in primary chondrocytes stimulated with tumour necrosis factor-alpha.	2001
Emeritus Professor John Harris Emeritus Professor Tim Cawston	Musculoskeletal pharmacology	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Oncostatin M in combination with TNF synergistically induces expression and production of matrix metaollproteinases and promotes cartlilage breakdown.	2001
Dr Steven Young-Min Emeritus Professor Tim Cawston	Serum TIMP-1, TIMP-2, and MMP-1 in patients with systemic sclerosis, primary Raynaud's phenomenon, and in normal controls	2001
Emeritus Professor Drew Rowan Paul Koshy Dr William Shingleton Dr Beverley Degnan Emeritus Professor Tim Cawston et al.	Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown	2001
Dr Jonathan Catterall Dr Severine Carrere Paul Koshy Dr Beverley Degnan Dr William Shingleton et al.	Synergistic induction of matrix metalloproteinase 1 by interleukin-1 alpha and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism	2001
Dr Jonathan Catterall Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	Synergistic regulation of chondrocytes by IL-1 and oncostatin M (OSM) involves interaction of JAK/STAT, MAPKinase and c-jun activation	2001
Dr Sarah Elliott Emeritus Professor Tim Cawston	The clinical potential of matrix metalloproteinase inhibitors in the rheumatic disorders	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Cartilage destruction in arthritis: Collagen and aggrecan-degrading proteinases	2000
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Cartilage destruction in Arthritis: Collagen and Aggrecan-degrading Proteins	2000
Dr Heather Bigg Emeritus Professor Tim Cawston	Mechanisms of induction of human tissue inhibitor of metalloproteinases-1 (TIMP-1) gene expression by all-trans retinoic acid in combination with basic fibroblast growth factor	2000
Dr Heather Bigg Emeritus Professor Drew Rowan Professor Derek Mann Emeritus Professor Tim Cawston	Regulation of human TIMP-1 Gene Expression	2000
Dr William Shingleton Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: Matrix metalloproteinases-1 and -13 are involved in cartilage collagen breakdown	2000
Dr William Shingleton Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: Matrix metalloproteinases-1 and-13 are involved in cartilage collagen breakdown	2000
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Transforming growth factor-beta 1 blocks the release of collagen fragments from bovine nasal cartilage stimulated by oncostatin M in combination with IL-1 alpha	2000
Paul Koshy Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	96-well plate assays for measuring collagenase activity using ³H-acetylated collagen	1999
Emeritus Professor Tim Cawston	A longitudinal study of anticardiolipin antibody levels and cognitive functioning in systemic lupus erythematosus	1999
Dr Heather Bigg Emeritus Professor Tim Cawston	Induction of human tissue inhibitor of metalloproteinase-1 gene expression by all-trans retinoic acid in combination with basic fibroblast growth factor involves both p42/44 and p38 MAP kinases	1999
Emeritus Professor Tim Cawston Paul Koshy Emeritus Professor Drew Rowan	The regulation of MMPs and TIMPs in cartilage turnover	1999
Emeritus Professor Tim Cawston Paul Koshy Emeritus Professor Drew Rowan	The regulation of MMPs and TIMPs in cartilage turnover	1999
Emeritus Professor Tim Cawston Paul Koshy Emeritus Professor Drew Rowan	The regulation of MMPs and TIMPs in cartilage turnover	1999
Emeritus Professor Tim Cawston	An aggrecan-degrading activity associated with chondrocyte membranes	1998
Emeritus Professor Tim Cawston	Matrix metalloproteinases and TIMPs: properties and implications for the rheumatic diseases	1998
Emeritus Professor Tim Cawston	Mechanisms of joint destruction and therapeutic approaches	1998
Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	Prevention of cartilage breakdown by matrix metalloproteinase inhibition - A realistic therapeutic target?	1998
Emeritus Professor Tim Cawston Paul Koshy Emeritus Professor Drew Rowan Dr William Shingleton	The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint	1998
Dr William Shingleton Emeritus Professor Tim Cawston	Cartilage canals in equine articular/epiphyseal growth cartilage and a possible association with dyschondroplasia	1997
Emeritus Professor Drew Rowan Professor Derek Mann Emeritus Professor Tim Cawston	Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1	1997
Dr William Shingleton Emeritus Professor Tim Cawston	Collagenase: A key enzyme in collagen turnover	1996
Emeritus Professor Tim Cawston	Prevalence and possible pathological significance of calcium phosphate salt accumulation in tendon matrix degeneration	1996
Emeritus Professor Tim Cawston	Tenascin-C and human tendon degeneration	1996
Emeritus Professor Tim Cawston	Tendon lesions and soft tissue rheumatism - Great outback or great opportunity?	1996