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Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by TGF-beta 1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-alpha

Lookup NU author(s): Emeritus Professor Drew Rowan, Emeritus Professor Tim Cawston

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Abstract

Tumour necrosis factor-alpha (TNF-alpha) was able to promote collagen breakdown from bovine cartilage in explant culture. This release was dependent upon matrix metalloproteinases (MMPs) and could be prevented by transforming growth factor-beta1 (TGF-beta1) or insulin-like growth factor-1. Both growth factors reduced the expression and secretion of collagenase enzymes, and TGF-beta1 induced tissue inhibitor of metalloproteinase production. This study shows for the first time that these anabolic growth factors can protect cartilage against TNF-alpha -induced destruction. (C) 2001 Academic Press.

Publication metadata

Author(s): Hui W, Rowan AD, Cawston TE

Publication type: Article

Publication status: Published

Journal: Cytokine

Year: 2001

Volume: 16

Issue: 1

Pages: 31-35

ISSN (print): 1043-4666

ISSN (electronic): 1096-0023

Publisher: Academic Press

URL: http://dx.doi.org/10.1006/cyto.2001.0950

DOI: 10.1006/cyto.2001.0950

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