Publications by Emeritus Professor Drew Rowan - ePrints

Browsing publications by Emeritus Professor Drew Rowan.

Newcastle Authors	Title	Year
Dr Matthew Barter Dr Sarah Rice Hua Lin Dr Adrian Falconer Dr Jamie Soul et al.	SERPINA3 is a marker of cartilage differentiation and is essential for the expression of extracellular matrix genes during early chondrogenesis	2024
Dr David Wilkinson Dr Adrian Falconer Hua Lin Kat Cheung Sarah Charlton et al.	Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.	2021
Dr Adrian Falconer Dr Chun Chan Dr Joseph Gray Emeritus Professor Drew Rowan Dr David Wilkinson et al.	Collagenolytic matrix metalloproteinases antagonize proteinase-activated receptor-2 activation, providing insights into extracellular matrix turnover	2019
Dr Florian Gothe Emeritus Professor Drew Rowan Angela Grainger Professor Andrew Cant Professor Mary Slatter et al.	Novel Gain-of-Function Mutation in Stat1 Sumoylation Site Leads to CMC/CID Phenotype Responsive to Ruxolitinib	2019
David Hodgson Emeritus Professor Drew Rowan Dr Carole Proctor	Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli	2019
Chris Macdonald Dr Adrian Falconer Dr Chun Chan Dr David Wilkinson Andrew Skelton et al.	Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes	2018
Jonathan Baker Adrian Falconer Dr David Wilkinson Emeritus Professor Nick Europe-Finner Dr Gary Litherland et al.	Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes	2018
Dr David Wilkinson Dr Maria Arques Mengual Emeritus Professor Drew Rowan	Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: Implications for therapeutics	2018
Dr David Wilkinson Andrew Skelton Emeritus Professor Nick Europe-Finner Emeritus Professor Drew Rowan	Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation.	2017
Dr David Wilkinson Angie Habgood Dr Heather Lamb Paul Thompson Professor Alastair Hawkins et al.	Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms	2017
Dr David Wilkinson Hua Lin Sarah Charlton Dr Adrian Falconer Dr Craig Bullock et al.	The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: Molecular mechanisms and implications for extracellular matrix turnover	2017
Dr Rachel Williams Andrew Skelton Dr Stephen Todryk Emeritus Professor Drew Rowan Professor Philip Preshaw et al.	Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts	2016
Emeritus Professor Drew Rowan Professor Iain McInnes Dr Carl Goodyear	Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology	2016
Dr Katherine Crossland Dr Chun Chan Tariq AlShehri Dr Mario Abinun Professor Andrew Gennery et al.	Gain-of-function STAT1 mutations impair STAT3 activity in patients with Chronic Mucocutaneous Candidiasis (CMC)	2015
Dr Dimitra Tsompani Dr Matthew Barter Emeritus Professor Drew Rowan Professor David Young	The role of Histone Deacetylase 3 in chondrogenesis and osteoarthritis	2015
Emeritus Professor Drew Rowan Dr Gary Litherland	Tribbles and arthritis: what are the links?	2015
Dr Carole Proctor Christopher Macdonald Dr Jenny Milner Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	A computer simulation approach for assessing therapeutic intervention points to prevent cytokine-induced cartilage breakdown	2014
Dr Marzena Ciechomska Dr Caroline Wilson Achilleas FLOUDAS Emeritus Professor Drew Rowan Professor John Robinson et al.	Antigen-specific B lymphocytes acquire proteoglycan aggrecan from cartilage extracellular matrix resulting in antigen presentation and CD4⁺ T-cell activation	2014
Emeritus Professor Drew Rowan Dr Carl Goodyear	Bone changes preceed cartilage degradation in experimental osteoarthritis	2014
Emeritus Professor Drew Rowan Ruth Wyllie Emerita Professor Helen Foster	Chronic arthritis in children and young people	2014
Dr Katherine Crossland Dr Mario Abinun Professor Andrew Gennery Professor Jelena Mann Dr Dennis Lendrem et al.	Gain-of-function stat1 mutation impairs stat3 function predisposing to chronic mucocutaneous candidiasis	2014
Dr Gary Litherland Martina Elias Dr David Wilkinson Sharon Watson Professor David Young et al.	Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis	2014
Professor David Young Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston Dr Carole Proctor	Investigating molecular mechanisms of ageing cartilage using computer simulation models	2014
Professor David Young Emeritus Professor Drew Rowan Xin Xu Emeritus Professor Tim Cawston Dr Carole Proctor et al.	Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage	2014
Dr Marta Radwan Dr David Wilkinson Dr Auriane Destrument Sarah Charlton Dr Matthew Barter et al.	Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination	2014
Emeritus Professor Tim Cawston Professor David Young Emeritus Professor Drew Rowan	Tissue destruction and repair	2014
Dr Carole Proctor Christopher Macdonald Dr Jenny Milner Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	A computer simulation approach for testing possible interventions to ameliorate collagen release	2013
Dr Matthew Barter Dr Auriane Destrument Jenny Scott Emeritus Professor Drew Rowan	Class I Histone Deacetylase Inhibition Modulates Metalloproteinase Expression and Blocks Cytokine-Induced Cartilage Degradation	2013
Rachel Williams Emeritus Professor Drew Rowan Professor Philip Preshaw Dr John Taylor	Leptin regulation of matrix metalloproteinase expression in human gingival fibroblasts	2013
Emeritus Professor Drew Rowan	Macrophage Migration and Invasion Is Regulated by MMP10 Expression	2013
Dr Marta Radwan Christos Gavriilidis Professor John Robinson Emeritus Professor Drew Rowan Professor David Young et al.	Matrix metalloproteinase-13 expression in response to double-stranded RNA in human chondrocytes	2013
Jonathan Baker Dr Gary Litherland Emeritus Professor Drew Rowan	The Role of Protein Kinase D Signalling in the Induction of Matric Metalloproteinases in Human Articular Chondrocytes	2013
Dr Catherine Bui Dr Matthew Barter Jenny Scott Dr Martin Galler Dr Louise Reynard et al.	cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis	2012
Yaobo Xu Dr Matthew Barter Dr Daniel Swan Dr Kenneth Rankin Emeritus Professor Drew Rowan et al.	Comparison of osteoarthritis and normal hip cartilage transcriptomes using RNA-seq reveals new candidate gene targets and associated pathways	2012
Jie Zheng Emeritus Professor Drew Rowan Professor Andrew Gennery Dr Mario Abinun Dr Desa Lilic et al.	Gain-of-function STAT1 mutations alter STAT3 activation in patients with chronic mucocutaneous candidiasis	2012
Dr Gary Litherland Martina Elias Hannah Curtis Emeritus Professor Drew Rowan	Glycogen synthase kinase-3 as a gatekeeper of human cartilage degradation	2012
Christopher Macdonald Emeritus Professor Drew Rowan Emeritus Professor Nick Europe-Finner	Identification of synergistic transcriptional regulation for collagenase gene expression in chondrocytes	2012
Yaobo Xu Dr Matthew Barter Dr Daniel Swan Dr Kenneth Rankin Emeritus Professor Drew Rowan et al.	Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA	2012
Dr Matthew Barter Dr Daniel Swan Dr Kenneth Rankin Emeritus Professor Drew Rowan Dr Mauro Santibanez Koref et al.	Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA	2012
Rachel Williams Emeritus Professor Drew Rowan Professor Philip Preshaw Dr John Taylor	Interleukin-1 and leptin synergistically enhance matrix metallo-proteinase expression in human gingival fibroblasts	2012
Dr Marta Radwan Emeritus Professor Drew Rowan Professor John Robinson Emeritus Professor Tim Cawston Professor David Young et al.	Involvement of pattern recognition receptors in poly(I:C)-mediated MMP-13 expression	2012
Dr Gary Litherland Madona Elias Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan Professor David Young et al.	Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases	2012
Dr Iain Goff Emeritus Professor Drew Rowan Dr Belinda Bateman Emerita Professor Helen Foster	Poor sensitivity of musculoskeletal history in children	2012
Dr Marzena Ciechomska Dr Caroline Wilson Emeritus Professor Drew Rowan Professor John Robinson Dr Andrew Knight et al.	Antigen-specific B cells can acquire and present the rheumatoid arthritis candidate autoantigen aggrecan from a non-internalisable surface	2011
Jie Zheng Emeritus Professor Drew Rowan Dr Desa Lilic	Effect of cytokine-induced STAT1 signaling on STAT3 activation and binding	2011
Dr Marta Radwan Emeritus Professor Drew Rowan Professor John Robinson Emeritus Professor Tim Cawston Professor David Young et al.	Pattern recognition receptors in osteoarthritic cartilage	2011
Emeritus Professor Tim Cawston Dr Rachel Lakey Emeritus Professor Drew Rowan	Assay of matrix metalloproteinases against matrix substrates	2010
Dr Marzena Ciechomska Dr Caroline Wilson Emeritus Professor Drew Rowan Professor John Robinson Dr Andrew Knight et al.	Examination of the ability of autoreactive B cells to acquire and present the rheumatoid arthritis candidate autoantigen, aggrecan, from a non-internalizable surface	2010
Dr Matthew Barter Leon Pybus Dr Gary Litherland Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	HDAC-mediated control of ERK- and PI3K-dependent TGF-beta-induced extracellular matrix-regulating genes	2010
Dr Hui Wang Emeritus Professor Tim Cawston Dr Gary Litherland Madona Elias Emeritus Professor Drew Rowan et al.	Leptin produced by joint white adipose tissue induces cartilage degradation by up-regulation and activation of matrix metalloproteinases	2010
Emeritus Professor Drew Rowan	Lipopolysaccharide modulates matrix metalloproteinase expression and cell migration in bone marrow-derived macrophages	2010
Dr Gary Litherland Dr Matthew Jefferson Dr Matthew Barter Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway	2010
Dr Jenny Milner Amit Patel Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis	2010
Dr Jenny Milner Amit Patel Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis	2010
Dr Jenny Milner Amit Patel Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Matriptase is a novel initiator of cartilage matrix resorptionm in osteoarthritis	2010
Emeritus Professor Drew Rowan	Overexpression of Oncostatin-M in lungs induces eotaxin-2 and eosinophil accumulation in C57BL/6 but not Balb/C mice in vivo	2010
Dr Gary Litherland Martina Elias Dr Jonathan Catterall Dr Matthew Barter Matthew Farren et al.	Protein Kinase C Isoforms ζ and Ɩ Mediate Collagenase Expression and Cartilage Destruction via STAT3- and ERK-dependent c-fos Induction	2010
Dr Rachel Lakey Emeritus Professor Drew Rowan Professor John Isaacs Emeritus Professor Tim Cawston Professor Catharien Hilkens et al.	A novel paradigm for dendritic cells as effectors of cartilage destruction	2009
Professor David Young Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Lithium inhibits cartilage degradation and MMP production induced by pro-inflammatory cytokines	2009
Emeritus Professor Drew Rowan	Differential responses to oncostatin-M in C57BL/6 and BALB/C mice in vivo	2008
Dr Gary Litherland Dr Matthew Barter Emeritus Professor Tim Cawston Professor John Robinson Emeritus Professor Drew Rowan et al.	Differential Toll-like receptor-dependent collagenase expression in chondrocytes	2008
Dr Jenny Milner Amit Patel Emeritus Professor Drew Rowan	Emerging Roles of Serine Proteinases in Tissue Turnover in Arthritis	2008
Emeritus Professor Drew Rowan Dr Gary Litherland Dr Jenny Milner	Metalloproteases as potential therapeutic targets in arthritis treatment	2008
Dr Matthew Jefferson Emeritus Professor Drew Rowan	STATs and c-fos are critical for synergistic MMP-1 induction in chondrocytes	2008
Dr Gary Litherland Dr Craig Dixon Dr Rachel Lakey Tim Robson David Jones et al.	Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent	2008
Dr Heather Bigg Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Activity of matrix metalloproteinase-9 against native collagen types I and III	2007
Emeritus Professor Drew Rowan Professor David Young	Collagenase gene regulation by pro-inflammatory cytokines in cartilage	2007
Dr Nicholas Peake Emerita Professor Helen Foster Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	Assessment of the clinical significance of gelatinase activity in patients with juvenile idiopathic arthritis using quantitative protein substrate zymography	2006
Dr Jonathan Catterall Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M	2006
Dr Jenny Milner Professor David Young David Jones Dr Emma Barksby Dr Angela Patterson et al.	Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis	2006
Dr Jenny Milner Professor David Jones Professor David Young Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis	2006
Dr Jenny Milner Professor David Young David Jones Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	Fibroblast-activation protein-alpha is expressed by chondrocytes following a proinflammatory stimulus and is elevated in osteoarthritis	2006
Emeritus Professor Drew Rowan Professor David Deehan Emeritus Professor Tim Cawston	Human nasal cartilage responds to oncostatin M in combination with interleukin 1 or tumour necrosis factor alpha by the release of collagen fragments via collagenases	2006
Dr Emma Barksby Ilka Wappler Dr Heiko Peters Dr Jenny Milner Emeritus Professor Tim Cawston et al.	Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes - Implications for cartilage destruction and repair	2006
Dr Nicholas Peake Dr Andrea Myers Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston Emerita Professor Helen Foster et al.	Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor	2006
Dr Emma Barksby Dr Jenny Milner Dr Angela Patterson Dr Nicholas Peake Tim Robson et al.	Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: Implications for cartilage degradation in arthritis	2006
Dr Jenny Milner Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston Professor David Young	Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis	2006
Dr William Shingleton Debra Jones Xin Xu Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Retinoic acid and oncostatin M combine to promote cartilage degradation via matrix metalloproteinase-13 expression in bovine but not human chondrocytes	2006
Dr Heather Bigg Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	The mammalian chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation	2006
Dr Nicholas Peake Emeritus Professor Drew Rowan Dr Andrea Myers Emeritus Professor Tim Cawston Emerita Professor Helen Foster et al.	Assessment of the clinical significance of MMP activity in juvenile idiopathic arthritis (JIA)	2005
Dr Nicholas Peake Emeritus Professor Drew Rowan Dr Andrea Myers Emeritus Professor Tim Cawston	Assessment of the clinical significance of MMPs in Juvenile Idiopathic Arthritis	2005
Katie Lowes Dr Alexei von Delwig Emeritus Professor Drew Rowan Professor John Robinson	CD4 T cells cross-react between several arthritogenic epitopes of aggrecan in BALB/c mice	2005
Dr Steven Young-Min Dr David Coady Sarah Charlton Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston et al.	Early rheumatoid arthritis patients with DR4 shared epitope alleles progress radiologically and have elevated levels of serum MMP-3, serum comp, urinary GLC-GAL-PYD and urinary collagen crosslinks	2005
Tina Xu Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Evaluation of chondrocyte micromass culture for the study of cartilage degradation	2005
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Human nasal cartilage responds to oncostatin M in combination with interleukin 1 or tumour necrosis factor α by the release of collagen fragments via collagenases	2005
Dr Nicholas Peake Dr Andrea Myers Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston Emerita Professor Helen Foster et al.	IL-6 and the soluble receptor in paired juvenile idiopathic arthritis (JIA) serum and SF samples	2005
Dr Nicholas Peake Dr Andrea Myers Debra Jones Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan et al.	Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study	2005
Emeritus Professor Tim Cawston Dr Heather Bigg Dr Jenny Milner Dr Jonathan Catterall Dr Emma Barksby et al.	Mechanisms of cartilage matrix turnover: synergistic interactions of proinflammatory cytokines with oncostatin M in upregulating matrix metalloproteinases and ADAMTS metalloproteinases	2005
Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	OM in combination with TNFalpha induces a chondrocyte membrane associated aggrecanase	2005
Dr Emma Barksby Professor David Young Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	Oncostatin M in combination with tumour necrosis factor alpha induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or-2	2005
Katie Lowes Dr Alexei von Delwig Professor Judith Goodship Emeritus Professor Drew Rowan Professor John Robinson et al.	Specificity of CD4 T cell responses to aggrecan in BALB/c and DR1 transgenic mice	2005
Katie Lowes Dr Alexei von Delwig Emeritus Professor Drew Rowan Professor John Robinson	Specificity of CD4 T-cell responses to aggrecan in BALB/c and DR1 transgenic mice	2005
Dr Steven Young-Min Emeritus Professor Drew Rowan Sarah Charlton Dr David Coady Emeritus Professor Tim Cawston et al.	The biallelic 1G/2G single nucleotide polymorphism at position-1607BP of the MMP-1 promoter is not associated with rheumatoid arthritis, does not significantly affect measured levels of serum MMP-1 and is not associated with increased radiographic destruction	2005
Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL	2004
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model	2003
Emeritus Professor Tim Cawston Dr Jenny Milner Dr Jonathan Catterall Emeritus Professor Drew Rowan	Cytokine synergy, collagenases and cartilage collagen breakdown	2003
Emeritus Professor Tim Cawston Dr Jenny Milner Dr Jonathan Catterall Emeritus Professor Drew Rowan	Cytokine synergy, collagenases and cartilage collagen breakdown	2003
Dr Jenny Milner Emeritus Professor Drew Rowan Dr Sarah Elliott Emeritus Professor Tim Cawston	Inhibition of furin-like enzymes blocks interleukin-1 alpha/oncostatin M-stimulated cartilage degradation	2003
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Oncostatin M in combination with tumor necrosis factor alpha induces cartilage damage and matrix metalloproteinase expression in vitro and in vivo	2003
Emeritus Professor Tim Cawston Dr Hui Wang Dr Christopher Richards Emeritus Professor Drew Rowan	Synergistic interactions of proinflammatory cytokines with oncostatin M: implications for joint destruction	2003
Professor David Young Emeritus Professor Drew Rowan	The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-β1	2003
Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	Transforming growth factor beta 1 and insulin-like growth factor 1 block collagen degradation induced by oncostatin M in combination with tumour necrosis factor alpha from bovine cartilage	2003
Dr Bijayeswar Vaidya Professor Simon Pearce Stephen Charlton Emeritus Professor Drew Rowan Professor Pat Kendall-Taylor et al.	An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies	2002
Dr Bijayeswar Vaidya Professor Simon Pearce Sarah Charlton Nicola Marshall Emeritus Professor Drew Rowan et al.	An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies	2002
Professor Christopher Ward Dr Gary Pritchard Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Co-localisation of MMP-9 with neutrophils in stable lung transplant recipients - A potential role in Bronchiolitis Obliterans	2002
Professor David Young Emeritus Professor Drew Rowan	Cryptic promoter activity of pBLCAT3 induced by overexpression of AP1 factors	2002
Paul Koshy Neil Henderson Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines	2002
Paul Koshy Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M - A time-course study using real-time quantitative reverse transcription-polymerase chain reaction	2002
Emeritus Professor Tim Cawston Paul Koshy Emeritus Professor Drew Rowan	Assays of matrix metalloproteinases against matrix substrates	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1α	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Insulin-like growth factor-1 blocks the release of collagen fragments from bovine nasal cartilage stimulated by oncostatin M in combination with interleukin-1	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Interleukin 13 blocks the release of collagen from bovine nasal cartilage treated with proinflammatory cytokines	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Interleukin-13 blocks the release of collagen fragments from bovine nasal cartilage treated with proinflammatory cytokines by preventing pro-collagenase activation	2001
Emeritus Professor Tim Cawston Dr Severine Carrere Dr Jonathan Catterall Dr Richard Duggleby Suzanne Elliott et al.	Matrix metalloproteinases and TIMPs: properties and implications for the treatment of chronc pulmonary disease	2001
Emeritus Professor Tim Cawston Dr Severine Carrere Dr Jonathan Catterall Dr Richard Duggleby Suzanne Elliott et al.	Matrix metalloproteinases and TIMPs: Properties and implications for the treatment of chronic obstructive pulmonary disease	2001
Emeritus Professor Tim Cawston Dr Severine Carrere Dr Jonathan Catterall Dr Richard Duggleby Suzanne Elliott et al.	Matrix metalloproteinases and TIMPs: properties and implications for the treatment of chronic obstructive pulmonary disease	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by TGF-beta 1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-alpha	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by transforming growth factor-beta 1 and insulin-like growth factor-1 in primary chondrocytes stimulated with tumour necrosis factor-alpha.	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Oncostatin M in combination with TNF synergistically induces expression and production of matrix metaollproteinases and promotes cartlilage breakdown.	2001
Emeritus Professor Drew Rowan Paul Koshy Dr William Shingleton Dr Beverley Degnan Emeritus Professor Tim Cawston et al.	Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown	2001
Dr Jonathan Catterall Dr Severine Carrere Paul Koshy Dr Beverley Degnan Dr William Shingleton et al.	Synergistic induction of matrix metalloproteinase 1 by interleukin-1 alpha and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism	2001
Dr Jonathan Catterall Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	Synergistic regulation of chondrocytes by IL-1 and oncostatin M (OSM) involves interaction of JAK/STAT, MAPKinase and c-jun activation	2001
Dr Heather Bigg Emeritus Professor Drew Rowan	The inhibition of metalloproteinases as a therapeutic target in rheumatoid arthritis and osteoarthritis	2001
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Cartilage destruction in arthritis: Collagen and aggrecan-degrading proteinases	2000
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Cartilage destruction in Arthritis: Collagen and Aggrecan-degrading Proteins	2000
Dr Heather Bigg Emeritus Professor Drew Rowan Professor Derek Mann Emeritus Professor Tim Cawston	Regulation of human TIMP-1 Gene Expression	2000
Dr William Shingleton Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: Matrix metalloproteinases-1 and -13 are involved in cartilage collagen breakdown	2000
Dr William Shingleton Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: Matrix metalloproteinases-1 and-13 are involved in cartilage collagen breakdown	2000
Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	Transforming growth factor-beta 1 blocks the release of collagen fragments from bovine nasal cartilage stimulated by oncostatin M in combination with IL-1 alpha	2000
Paul Koshy Emeritus Professor Drew Rowan Emeritus Professor Tim Cawston	96-well plate assays for measuring collagenase activity using ³H-acetylated collagen	1999
Emeritus Professor Drew Rowan Dr Eugene Healy	Somatic mutations in the Peutz-Jegners (LKB1/STKII) gene in sporadic malignant melanomas	1999
Emeritus Professor Tim Cawston Paul Koshy Emeritus Professor Drew Rowan	The regulation of MMPs and TIMPs in cartilage turnover	1999
Emeritus Professor Tim Cawston Paul Koshy Emeritus Professor Drew Rowan	The regulation of MMPs and TIMPs in cartilage turnover	1999
Emeritus Professor Tim Cawston Paul Koshy Emeritus Professor Drew Rowan	The regulation of MMPs and TIMPs in cartilage turnover	1999
Emeritus Professor Tim Cawston Emeritus Professor Drew Rowan	Prevention of cartilage breakdown by matrix metalloproteinase inhibition - A realistic therapeutic target?	1998
Emeritus Professor Tim Cawston Paul Koshy Emeritus Professor Drew Rowan Dr William Shingleton	The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint	1998
Emeritus Professor Drew Rowan Professor Derek Mann Emeritus Professor Tim Cawston	Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1	1997