Professor David Kavanagh
| An expert discussion on the atypical hemolytic uremic syndrome nomenclature—identifying a road map to precision: a report of a National Kidney Foundation Working Group | 2024 |
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Anneliza Andreadi Dr Vicky Brocklebank Professor Kevin Marchbank Professor Claire Harris Professor David Kavanagh et al. | Comprehensive functional characterization of complement factor I rare variant genotypes identified in the SCOPE geographic atrophy cohort | 2024 |
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Dr Sally Johnson Professor David Kavanagh Professor John Sayer Dr Edwin Wong Megan Bates et al. | Description and Cross-Sectional Analyses of 25,880 Adults and Children in the UK National Registry of Rare Kidney Diseases Cohort | 2024 |
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Dr Sally Johnson Professor David Kavanagh Professor John Sayer Dr Edwin Wong Dr Vicky Brocklebank et al. | Effects of rare kidney diseases on kidney failure: a longitudinal analysis of the UK National Registry of Rare Kidney Diseases (RaDaR) cohort | 2024 |
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Emily Glover Professor David Kavanagh Professor Neil Sheerin
| Kidney Transplantation in Patients with aHUS: A Comparison of Eculizumab Prophylaxis Versus Rescue Therapy | 2024 |
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Professor David Kavanagh Dr Vicky Brocklebank Professor Neil Sheerin
| Outcomes from the International Society of Nephrology Haemolytic Uraemic Syndromes International Forum | 2024 |
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Professor David Kavanagh
| Ravulizumab in Atypical Hemolytic Uremic Syndrome: An Analysis of Two-Year Efficacy and Safety Outcomes in Two Phase 3 Trials | 2024 |
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Dr Edwin Wong Lee-Ann Naidoo Sarah Winn Dr Patrick Walsh Dr Vicky Brocklebank et al. | The Annual Report of the National Renal Complement Therapeutics Centre 2022/23 | 2024 |
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Emily Glover Dr Kate Smith-Jackson Dr Vicky Brocklebank Dr Valerie Wilson Dr Patrick Walsh et al. | Assessing the Impact of Prophylactic Eculizumab on Renal Graft Survival in Atypical Hemolytic Uremic Syndrome | 2023 |
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Dr Vicky Brocklebank Dr Patrick Walsh Dr Kate Smith-Jackson Dr Thomas Hallam Professor Kevin Marchbank et al. | Atypical haemolytic uraemic syndrome in the era of terminal complement inhibition- An observational cohort study | 2023 |
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Dr Thomas Hallam Anneliza Andreadi Professor David Kavanagh
| Complement Factor I: regulatory nexus, driver of immunopathology, and therapeutic | 2023 |
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Professor David Kavanagh
| Design and Rationale of the APPELHUS Phase 3 Open-Label Study of Factor B Inhibitor Iptacopan for Atypical Hemolytic Uremic Syndrome | 2023 |
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Professor Kevin Marchbank Professor David Kavanagh Professor Claire Harris
| Editorial | 2023 |
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Dr Edwin Wong Professor David Kavanagh
| Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy | 2023 |
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Professor David Kavanagh
| Iptacopan in Idiopathic Immune Complex–Mediated Membranoproliferative Glomerulonephritis: Protocol of the APPARENT Multicenter, Randomized Phase 3 Study | 2023 |
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Dr Edwin Wong Sarah Winn Dr Michal Malina Dr Sally Johnson Professor Neil Sheerin et al. | The Annual Report of the National Renal Complement Therapeutics Centre 2021/22 | 2023 |
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Dr Thomas Hallam Tom Cox Dr Kate Smith-Jackson Dr Vicky Brocklebank April Baral et al. | A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in Age-related Macular Degeneration | 2022 |
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Professor David Kavanagh
| Alternative Complement Pathway Inhibition With Iptacopan for the Treatment of C3 Glomerulopathy-Study Design of the APPEAR-C3G Trial | 2022 |
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Professor David Kavanagh
| Complement and the prothrombotic state | 2022 |
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Dr Gemma Thompson Professor David Kavanagh
| Diagnosis and treatment of thrombotic microangiopathy | 2022 |
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Professor Claire Harris Professor David Kavanagh
| Evaluating a causal relationship between Complement Factor I protein level and advanced age-related macular degeneration using Mendelian Randomisation | 2022 |
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Dr Patrick Walsh Professor David Kavanagh
| None Fits All: Unraveling Structural Rearrangements of the CFH Gene Cluster in Atypical Hemolytic Uremic Syndrome Patients Using Molecular Combing and Long-Fragment Targeted Sequencing | 2022 |
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Nik Tzoumas Professor David Kavanagh Professor Heather Cordell Professor David Steel
| Rare complement factor I variants associated with reduced macular thickness and age-related macular degeneration in the UK Biobank | 2022 |
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Sarah Dunn Abishek Umashankar Andrew Bryant Dr Sonya Carnell Dr Thomas Chadwick et al. | Saftey and impact of eculizumab withdrawal in patients with atypical haemolytic uraemic syndrome: protocol for a multicentre, open-label, prospective, single-arm study | 2022 |
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Professor David Kavanagh
| Use of a B-cell depleting regimen for antifactor H autoantibody-mediated membranoproliferative glomerulonephritis in a paediatric patient | 2022 |
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Professor Kevin Marchbank Dr Isabel Pappworth Harriet Denton Kate Cooke Grant Richardson et al. | C3 Glomerulopathy and Related Disorders in Children. | 2021 |
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Dr Edwin Wong Thomas Hallam Dr Vicky Brocklebank Dr Patrick Walsh Dr Kate Smith-Jackson et al. | Functional characterisation of rare genetic variants in the N-terminus of complement factor H in aHUS, C3G and AMD | 2021 |
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Dr Ola Kamala Dr Thomas Hallam Tom Cox Dr Yi Yang Dr Falguni Vyas et al. | Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice | 2021 |
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Professor David Kavanagh
| Interventions for atypical haemolytic uraemic syndrome. | 2021 |
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Professor David Kavanagh
| Long-Term Efficacy and Safety of the Long-Acting Complement C5 Inhibitor Ravulizumab for the Treatment of Atypical Hemolytic Uremic Syndrome in Adults | 2021 |
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Professor David Steel Professor David Kavanagh
| Prevalence and phenotype associations of complement factor I mutations in geographic atrophy | 2021 |
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Nik Tzoumas Dr Dean Hallam Professor Claire Harris Professor Majlinda Lako Professor David Kavanagh et al. | Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants. | 2021 |
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Dr Edwin Wong Sarah Winn Dr Michal Malina Dr Sally Johnson Professor Neil Sheerin et al. | The Annual Report of the National Renal Complement Therapeutics Centre 2020/21 | 2021 |
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Tom Hallam Gladys - Nik Tzoumas David Steel Victoria Shuttleworth et al. | The Rare C9 P167S Risk Variant for Age-related Macular Degeneration Increases Polymerization of the Terminal Component of the Complement Cascade | 2021 |
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Professor David Kavanagh
| Cocaine-associated atypical haemolytic uraemic syndrome in a genetically susceptible individual | 2020 |
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Dr Tom Altmann Dr Stephen Owens Dr Dipayan Mitra Professor Neil Sheerin Professor David Kavanagh et al. | Complement Factor I deficiency: a potentially treatable cause of fulminant cerebral inflammation | 2020 |
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Edvinas Cerniauskas Dr Marzena Kurzawa-Akanbi Dr Long Xie Dr Dean Hallam Marina Moya Molina et al. | Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of AMD by restoring lysosomal function | 2020 |
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Professor David Kavanagh
| Functional Analysis of Rare Genetic Variants in Complement Factor I (CFI) using a Serum-Based Assay in Advanced Age-related Macular Degeneration | 2020 |
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Dr Vicky Brocklebank Dr Kate Smith-Jackson Dr Patrick Walsh Professor Kevin Marchbank Professor Claire Harris et al. | Long-term outcomes and response to treatment in DGKE nephropathy | 2020 |
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Professor David Kavanagh
| Management of thrombotic microangiopathy in pregnancy and postpartum: report from an international multidisciplinary working group. | 2020 |
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Dr Zohreh Nademi Dr Alex Battersby Dr Terence Flood Dr Stephen Owens Professor Andrew Cant et al. | New Insights Into Risk Factors for Transplant-Associated Thrombotic Microangiopathy in Pediatric HSCT | 2020 |
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Dr Sanj Ugrinovic Professor David Kavanagh
| Primary pneumococcal peritonitis can be the first presentation of a familial complement factor I deficiency | 2020 |
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Tom Hallam Professor Kevin Marchbank Professor Claire Harris Victoria Shuttleworth Professor David Kavanagh et al. | Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration | 2020 |
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Dr Edwin Wong Lisa Batchelor Dr Michal Malina Dr Sally Johnson Professor Neil Sheerin et al. | The Annual Report of the National Renal Complement Therapeutics Centre 2019/20 | 2020 |
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Professor David Kavanagh
| The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment | 2020 |
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Dr Veronique Fremaux-Bacchi Professor David Kavanagh
| C3 glomerulopathy — understanding a rare complement-driven renal disease | 2019 |
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Dr Kate Smith-Jackson Dr Yi Yang Harriet Denton Katie Cooke Professor David Kavanagh et al. | Hyper-functional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice | 2019 |
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Dr Christopher Duncan Dr Benjamin Thompson Dr Rui Chen Dr Florian Gothe Victoria Shuttleworth et al. | Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2 | 2019 |
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Dr Edwin Wong Jo Stout Jalibani Ndebele Angela Watt Lisa Batchelor et al. | The Annual Report of the National Renal Complement Therapeutics Centre 2018/19 | 2019 |
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Dr Patrick Walsh Professor David Kavanagh
| Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism | 2018 |
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Professor Claire Harris Professor David Kavanagh Dr Ruyue Sun
| Developments in anti-complement therapy; from disease to clinical trial | 2018 |
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Dr Edwin Wong Professor David Kavanagh
| Diseases of complement dysregulation—an overview | 2018 |
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Dr Patrick Walsh Dr Sally Johnson Dr Vicky Brocklebank Dr Jacobo Salvatore Professor David Kavanagh et al. | Glucose-6-Phosphate Dehydrogenase Deficiency Mimicking Atypical Hemolytic Uremic Syndrome | 2018 |
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Professor David Kavanagh
| Introduction to complement in health and disease: novel aspects and insights. | 2018 |
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Professor David Kavanagh Dr Valerie Wilson Professor Tim Goodship
| Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy | 2018 |
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Dr Edwin Wong Jo Stout Jalibani Ndebele Angela Watt Dr Michal Malina et al. | The Annual Report of the National Renal Complement Therapeutics Centre 2017/18 | 2018 |
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Dr Vicky Brocklebank Dr Katrina Wood Professor David Kavanagh
| Thrombotic microangiopathy and the kidney | 2018 |
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Dr Dean Hallam Dr Joseph Collin Dr Sanja Bojic Dr Valeria Chichagova Dr Adriana Buskin et al. | An iPSC patient specific model of CFH (Y402H) polymorphism displays characteristic features of AMD and indicates a beneficial role for UV light exposure | 2017 |
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Dr Vicky Brocklebank Professor David Kavanagh
| Complement C5-inhibiting therapy for the thrombotic microangiopathies: accumulating evidence, but not a panacea | 2017 |
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Dr Edwin Wong Dr Yi Yang Professor Kevin Marchbank Professor David Kavanagh
| Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self surface-selective regulation of complement activation | 2017 |
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Dr Vicky Brocklebank Dr Sally Johnson Dr Patrick Walsh Dr Edwin Wong Dr Larissa Kerecuk et al. | Factor H autoantibody is associated with atypical hemolytic uremic syndrome in children in the United Kingdom and Ireland | 2017 |
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Professor David Kavanagh
| Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation | 2017 |
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Professor David Kavanagh Dr Edwin Wong Dr Vicky Brocklebank
| Hemolytic Uremic Syndrome in Pregnancy and Post-Partum | 2017 |
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Dr Katrina Wood Dr Alison Brown Professor David Kavanagh Dr Vicky Brocklebank
| Rare genetic variants in Shiga toxin–associated haemolytic uraemic syndrome: genetic analysis prior to transplantation is essential | 2017 |
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Dr Edwin Wong Dr Sally Johnson Professor Neil Sheerin Professor David Kavanagh
| The Annual Report of the National Renal Complement Therapeutics Centre 2016/2017 | 2017 |
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Rachel Challis Dr Edwin Wong Dr Vicky Brocklebank Dr Valerie Wilson Professor Kevin Marchbank et al. | Thrombotic Microangiopathy in Inverted Formin 2-Mediated Renal Disease | 2017 |
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Rachel Challis Dr Edwin Wong Dr Holly Anderson Dr Valerie Wilson Dr Vicky Brocklebank et al. | A De Novo Deletion in the Regulators of Complement Activation Cluster Producing a Hybrid Complement Factor H/Complement Factor H–Related 3 Gene in Atypical Hemolytic Uremic Syndrome | 2016 |
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Professor Neil Sheerin Professor David Kavanagh Professor Tim Goodship Dr Sally Johnson
| A national specialised service in England for atypical haemolytic uraemic syndrome – the first year’s experience | 2016 |
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Dr Valerie Wilson Tom Cox Dr Kate Smith-Jackson Professor David Kavanagh Professor Tim Goodship et al. | Chromosomal rearrangement – a rare cause of complement factor I associated atypical haemolytic uraemic syndrome | 2016 |
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Professor David Kavanagh Dr Kate Smith-Jackson
| Eculizumab in children with hemolytic uremic syndrome | 2016 |
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Professor David Kavanagh
| Role of factor H and effects of C-terminal mutations on control of human platelet/granulocyte aggregate formation | 2016 |
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Dr Vicky Brocklebank Dr Edwin Wong Professor Kevin Marchbank Professor Tim Goodship Professor David Kavanagh et al. | The role of ADAMTS-13 activity and complement mutational analysis in differentiating acute thrombotic microangiopathies | 2016 |
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Professor David Kavanagh Rachel Challis
| Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature | 2016 |
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Dr Edwin Wong Professor David Kavanagh
| Anticomplement C5 therapy with eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome | 2015 |
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Dr Veronique Fremaux-Bacchi Professor Tim Goodship Professor David Kavanagh
| Atypical aHUS: State of the art | 2015 |
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Rachael Horbury Dr Karim Bennaceur Catriona Barker Professor David Kavanagh Professor Tim Goodship et al. | Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS) | 2015 |
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Dr Edwin Wong Dr Vicky Brocklebank Professor Tim Goodship Professor David Kavanagh Dr Anna Richards et al. | Characterisation of a C3 Mutation with Increased Resistance to Complement Regulation in an Individual with Recurrent C3GN in a Renel Transplant | 2015 |
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Dr Edwin Wong Rachel Challis Professor Neil Sheerin Dr Sally Johnson Professor David Kavanagh et al. | Patient stratification and therapy in atypical haemolytic uraemic syndrome (aHUS) | 2015 |
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Dr Mustafa Sevinc Dr Vicky Brocklebank Professor Tim Goodship Professor David Kavanagh
| Plasma resistant atypical hemolytic uremic syndrome associated with a CFH mutation treated with eculizumab: A case report | 2015 |
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Professor David Kavanagh
| Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels | 2015 |
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Professor David Kavanagh
| Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum Factor I level | 2015 |
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Professor David Kavanagh
| Structural basis for sialic acid-mediated self-recognition by complement factor H | 2015 |
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Professor David Kavanagh
| Successful Treatment of Atypical Hus with Eculizumab in Emirati Child with Novel DGKE Gene Mutation | 2015 |
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Dr Vicky Brocklebank Dr Edwin Wong Professor Tim Goodship Professor David Kavanagh
| Atypical haemolytic uraemic syndrome associated with a CD46 mutation triggered by Shigella flexneri | 2014 |
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Catriona Barker Professor David Kavanagh Professor Tim Goodship Dr Isabel Pappworth
| Autoantibodies to CD59, CD55, CD46 and CD35 are not associated with aHUS | 2014 |
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Dr Edwin Wong Dr Holly Anderson Rachel Challis Dr Lisa Turnbull Gladys - et al. | Characterization of a Factor H Mutation That Perturbs the Alternative Pathway of Complement in a Family with Membranoproliferative GN | 2014 |
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Professor David Kavanagh Professor Neil Sheerin
| Management of hemolytic uremic syndrome | 2014 |
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Dr Vicky Brocklebank Professor David Kavanagh
| Protecting the kidney from complement: atypical haemolytic uraemic syndrome | 2014 |
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Professor David Kavanagh
| Thrombotic Microangiopathy Associated with Interferon Beta | 2014 |
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Dr Edwin Wong Professor David Kavanagh
| Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration | 2014 |
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Rachel Challis Dr Holly Anderson Dr Edwin Wong Dr Lisa Turnbull Professor Kevin Marchbank et al. | Atypical haemolytic uraemic syndrome associated with a novel hybrid CFH/CFHR3 gene | 2013 |
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Professor David Kavanagh Professor Tim Goodship Dr Anna Richards
| Atypical hemolytic uremic syndrome | 2013 |
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Dr Edwin Wong Professor Tim Goodship Professor David Kavanagh
| Complement therapy in atypical haemolytic uraemic syndrome (aHUS) | 2013 |
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Dr Lucy Holmes Dr Lisa Turnbull Dr Iain Moore Professor Kevin Marchbank Professor David Kavanagh et al. | Determining the Population Frequency of the CFHR3/CFHR1 Deletion at 1q32 | 2013 |
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Dr Holly Anderson Professor David Kavanagh
| Rare variants in CFI, C3 and C9 are associated with high risk of advancedage-related macular degeneration. | 2013 |
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Professor David Kavanagh Dr Lisa Turnbull Professor Kevin Marchbank Professor Claire Harris Professor Tim Goodship et al. | A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion in familial atypical hemolytic uremic syndrome | 2012 |
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Professor Tim Goodship Dr Isabel Pappworth Dr Iain Moore Dr Eva-Maria Hunze James Staniforth et al. | Factor H autoantibodies in membranoproliferative glomerulonephritis | 2012 |
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Professor David Kavanagh Dr Isabel Pappworth Christine Hayes Dr Iain Moore Dr Eva-Maria Hunze et al. | Factor I Autoantibodies in Patients with Atypical Hemolytic Uremic Syndrome: Disease-Associated or an Epiphenomenon? | 2012 |
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Dr Edwin Wong Dr Holly Anderson Rachel Challis Professor Kevin Marchbank Professor David Kavanagh et al. | Familial membranoproliferative glomerulonephritis type I associated with a functionally significant mutation in complement factor H | 2012 |
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Professor David Kavanagh Marie Appleton Professor Kim Bartlett
| Interference of urinary amino acid analysis by pregabalin | 2012 |
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Professor David Kavanagh Dr Holly Anderson
| Interpretation of genetic variants of uncertain significance in atypical hemolytic uremic syndrome | 2012 |
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Professor David Kavanagh
| Structural and Functional Characterization of the Product of Disease-Related Factor H Gene Conversion | 2012 |
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Professor David Kavanagh
| Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H | 2011 |
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Professor David Kavanagh Professor Claire Harris
| Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities | 2011 |
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Professor David Kavanagh Professor Tim Goodship
| Haemolytic Uraemic Syndrome | 2011 |
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Professor David Kavanagh Professor Tim Goodship Dr Veronique Fremaux-Bacchi
| Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort | 2011 |
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Professor David Kavanagh
| Structural basis for engagement by complement factor H of C3b on a self surface | 2011 |
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Professor David Kavanagh Dr Lisa Turnbull Professor Kevin Marchbank Professor Tim Goodship
| A novel hybrid complement gene associated with familial haemolytic uraemic syndrome | 2010 |
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Dr Iain Moore Dr Lisa Turnbull Dr Isabel Pappworth Professor David Kavanagh James Staniforth et al. | Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome | 2010 |
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Professor David Kavanagh Professor Tim Goodship
| Atypical hemolytic uremic syndrome | 2010 |
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Dr Isabel Pappworth Dr Iain Moore Dr Lisa Turnbull Professor David Kavanagh James Staniforth et al. | Complement Factor H Autoantibodies and Age-Related Macular Degeneration | 2010 |
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Dr Isabel Pappworth Professor David Kavanagh Dr Iain Moore Dr Lisa Turnbull
| Factor H autoantibodies are associated with MPGN | 2010 |
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Professor David Kavanagh Dr Isabel Pappworth Dr John Tapson Dr Iain Moore Dr Lisa Turnbull et al. | Factor I autoantibodies are associated with atypical haemolytic uraemic syndrome | 2010 |
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Professor David Kavanagh Dr Lisa Turnbull Professor Kevin Marchbank Professor Tim Goodship
| Functional characterisation of a novel hybrid complement factor H protein associated with atypical haemolytic uraemic | 2010 |
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Professor David Kavanagh Professor Tim Goodship
| Genetics and complement in atypical HUS | 2010 |
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Professor David Kavanagh Professor Tim Goodship Dr Veronique Fremaux-Bacchi
| Mutations in complement regulatory proteins predispose to preeclampsia | 2010 |
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Professor Tim Goodship Professor David Kavanagh
| Pulling the Trigger in Atypical Hemolytic Uremic Syndrome: The Role of Pregnancy | 2010 |
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Professor David Kavanagh Professor Tim Goodship
| Transplantation in Atypical Hemolytic Uremic Syndrome | 2010 |
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Professor Kevin Marchbank Professor David Kavanagh Dr Lisa Turnbull Professor Tim Goodship
| Triggering of atypical hemolytic uremic syndrome by influenza A (H1N1) | 2010 |
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Professor Kevin Marchbank Dr Lisa Turnbull Dr Veronique Fremaux-Bacchi James Staniforth Professor David Kavanagh et al. | Genomic disorders associated with aHUS | 2009 |
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Dr Anna Richards Professor David Kavanagh
| Pathogenesis of thrombotic microangiopathy: insights from animal models | 2009 |
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Professor David Kavanagh
| The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome | 2009 |
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James Staniforth Professor David Kavanagh Dr Lisa Turnbull Professor Tim Goodship Professor Kevin Marchbank et al. | Towards a highly specific Factor H ELISA for rapid screening of patient sera | 2009 |
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Professor David Kavanagh
| A New Map of Glycosaminoglycan and C3b Binding Sites on Factor H | 2008 |
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Dr Matthew Edey Professor David Kavanagh Dr Anne Lampe Professor Judith Goodship Dr Lisa Turnbull et al. | A Novel Non-Synonymous Polymorphism (p.Arg240His) in C4b-Binding Protein Is Associated with Atypical Hemolytic Uremic Syndrome and Leads to Impaired Alternative Pathway Cofactor Activity | 2008 |
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Professor David Kavanagh
| Advances in understanding of pathogenesis of aHUS and HELLP | 2008 |
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Professor David Kavanagh Dr Anna Richards
| Complement regulatory genes and hemolytic uremic syndromes | 2008 |
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Professor David Kavanagh
| New roles for the major human 3′-5′ exonuclease TREX1 in human disease | 2008 |
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Professor David Kavanagh
| Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations | 2008 |
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Professor David Kavanagh Dr Matthew Edey Dr Lisa Turnbull Professor Judith Goodship Dr Anne Lampe et al. | A non-synonymous polymorphism (arg240his) in C4b-binding protein is associated with atypical haemolytic uraemic syndrome and leads to impaired alternative pathway cofactor activity | 2007 |
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Professor David Kavanagh
| C-terminal truncations in human 3′-5′ DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy | 2007 |
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Professor David Kavanagh Dr Veronique Fremaux-Bacchi Professor Tim Goodship
| Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome | 2007 |
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Professor David Kavanagh
| Inherited complement regulatory protein deficiency predisposes to human disease in acute injury and chronic inflammatory statesthe examples of vascular damage in atypical hemolytic uremic syndrome and debris accumulation in age-related macular degeneration | 2007 |
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Professor David Kavanagh Dr Veronique Fremaux-Bacchi Professor Tim Goodship
| Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome | 2007 |
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Professor David Kavanagh Rachel Burgess Professor Judith Goodship Professor Tim Goodship
| The decay accelerating factor mutation I197V found in hemolytic uraemic syndrome does not impair complement regulation | 2007 |
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Professor David Kavanagh Professor Tim Goodship
| Update on evaluating complement in hemolytic uremic syndrome | 2007 |
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Professor David Kavanagh Professor Tim Goodship Dr Anna Richards
| Atypical haemolytic uraemic syndrome | 2006 |
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Professor David Kavanagh Dr Anna Richards Rachel Burgess Professor Judith Goodship Professor Tim Goodship et al. | Does complement factor B have a role in the pathogenesis of atypical HUS? | 2006 |
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Professor David Kavanagh
| Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications | 2006 |
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Dr Veronique Fremaux-Bacchi Professor David Kavanagh
| Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome | 2006 |
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Professor David Kavanagh
| Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome | 2006 |
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Professor David Kavanagh Professor Tim Goodship
| Membrane cofactor protein and factor I: Mutations and transplantation | 2006 |
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Emeritus Professor Geoffrey Toms Professor David Kavanagh
| Acute respiratory infection in a renal transplant recipient | 2005 |
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Professor David Kavanagh
| Hemolytic uremic syndrome: an example of insufficient complement regulation on self-tissue | 2005 |
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Professor David Kavanagh Dr Liz Kemp Professor Judith Goodship Professor Tim Goodship
| Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome | 2005 |
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Professor David Kavanagh
| Risk factors for restless legs syndrome in dialysis patients | 2005 |
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Professor David Kavanagh
| Peritoneal dialysis-associated peritonitis in Scotland (1999-2002) | 2004 |
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Professor David Kavanagh
| Restless legs syndrome in patients on dialysis | 2004 |
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Professor David Kavanagh
| The influence of pre-operative electrocardiographic abnormalities and cardiovascular risk factors on patient and graft survival following renal transplantation | 2002 |
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Professor David Kavanagh
| Electrocardiogram and Outcome following Renal Transplantation | 1999 |
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