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Lookup NU author(s): Dr Gemma Thompson, Professor David KavanaghORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Thrombotic microangiopathy (TMA) is characterised by thrombocytopenia, microangiopathic haemolytic anaemia and end organ damage. TMAs have varying underlying pathophysiology and can therefore present with an array of clinical presentations. Renal involvement is common as the kidney is particularly susceptible to the endothelial damage and microvascular occlusion. TMAs require rapid assessment, diagnosis, and commencement of appropriate treatment due to the high morbidity and mortality associated with them. Ground-breaking research into the pathogenesis of TMAs over the past 20 years has driven the successful development of targeted therapeutics revolutionising patient outcomes. This review outlines the clinical presentations, pathogenesis, diagnostic tests and treatments for TMAs.
Author(s): Thompson GL, Kavanagh D
Publication type: Article
Publication status: Published
Journal: International Journal of Laboratory Hematology
Year: 2022
Volume: 44
Issue: S1
Pages: 101-113
Online publication date: 08/09/2022
Acceptance date: 28/07/2022
Date deposited: 16/08/2022
ISSN (print): 1751-5521
ISSN (electronic): 1751-553X
Publisher: Wiley-Blackwell Publishing Ltd
URL: https://doi.org/10.1111/ijlh.13954
DOI: 10.1111/ijlh.13954
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