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Lookup NU author(s): Professor David KavanaghORCiD
This is the authors' accepted manuscript of an article that has been published in its final definitive form by Wiley-Blackwell Publishing Ltd., 2020.
For re-use rights please refer to the publisher's terms and conditions.
Atypical haemolytic uraemic syndrome (aHUS) is a severe, life-threateningcondition that requires early recognition and urgent treatment. In aHUS rare genetic variantsin CFH, CFI, CD46, C3 and CFB predispose to complement over activation. This casedescribes a case of aHUS in which there was a strong temporal association between diseaseonset and the use of smoked cocaine. The patient was found to have a rare genetic variant inthe CFI gene which may have been unmasked by first-time exposure to cocaine. The patientstabilised and improved with early administration of eculizumab, supporting the notion of anunderlying immunological pathogenesis and the importance of early intervention.
Author(s): Bongetti E, Kavanagh D, Martin K, Bendall A, Hill P, Steinberg A, Rajaram Y, Ierino F
Publication type: Article
Publication status: Published
Journal: Nephrology
Year: 2020
Volume: 25
Issue: 7
Pages: 518-521
Print publication date: 01/07/2020
Online publication date: 04/01/2020
Acceptance date: 02/12/2019
Date deposited: 06/01/2020
ISSN (print): 1320-5358
ISSN (electronic): 1440-1797
Publisher: Wiley-Blackwell Publishing Ltd.
URL: https://doi.org/10.1111/nep.13690
DOI: 10.1111/nep.13690
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