Publications by Dr Gabriele Saretzki - ePrints

Browsing publications by Dr Gabriele Saretzki.

Newcastle Authors	Title	Year
Dr Tengfei Wan Mary Johnson Professor Viktor Korolchuk Dr Gabriele Saretzki	Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson’s disease associated with enhanced autophagy	2021
Dr Gabriele Saretzki	Endometriosis is associated with a significant increase in hTERC and altered telomere/telomerase associated genes in the eutopic endometrium; an ex-vivo and in silico study	2020
Dr Gabriele Saretzki	Human endometrial carcinogenesis is associated with significant reduction in Long non-coding RNA, TERRA	2020
Dr Carmen Martin-Ruiz Professor Alison Yarnall Dr John Boucher Dr Rachael Lawson Claire Kolenda et al.	Senescence and inflammatory markers for predicting clinical progression in Parkinson's disease-the ICICLE-PD study	2020
Dr Danny Chan Dr Carmen Martin-Ruiz Dr Gabriele Saretzki Dr R Neely Professor Vijay Kunadian et al.	The association of telomere length and telomerase activity with adverse outcomes in older patients with non-ST-elevation acute coronary syndrome	2020
Dr Gabriele Saretzki	The wonderful new world of telomerase in the brain and its possible implications for neurodegenerative diseases	2020
Dr Mikolaj Ogrodnik Dr Olena Kucheryavenko Julien Glibert Dr Satomi Miwa Abbas Ishaq et al.	The bystander effect contributes to the accumulation of senescent cells in vivo	2019
Abbas Ishaq Julia Schroder Miss Edwards Professor Thomas von Zglinicki Dr Gabriele Saretzki et al.	Dietary restriction ameliorates age-related increase in DNA damage, senescence and inflammation in mouse adipose tissuey	2018
Dario Melguizo Sanchis Dr Yaobo Xu Dheraj Taheem Dr Min Yu Dr Katarzyna Tilgner et al.	iPSC modelling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors	2018
Abbas Ishaq Damien Dufour Dr Kerry Cameron Professor Thomas von Zglinicki Dr Gabriele Saretzki et al.	Metabolic memory of dietary restriction ameliorates DNA damage and adipocyte size in mouse visceral adipose tissue	2018
Professor Gavin Richardson Dr Karim Bennaceur Emily Dookun Lilia Draganova Dr Gabriele Saretzki et al.	Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells	2018
Dr Gabriele Saretzki	Telomeres, Telomerase and Ageing	2018
Dr Dean Hallam Dr Joseph Collin Dr Sanja Bojic Dr Valeria Chichagova Dr Adriana Buskin et al.	An iPSC patient specific model of CFH (Y402H) polymorphism displays characteristic features of AMD and indicates a beneficial role for UV light exposure	2017
Dr Valeria Chichagova Dr Dean Hallam Dr Joseph Collin Dr Adriana Buskin Dr Gabriele Saretzki et al.	Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring the m.3243A>G mitochondrial DNA mutation	2017
Dr Satomi Miwa Dr Gabriele Saretzki	Telomerase and mTOR in the brain: The mitochondria connection	2017
Dr Satomi Miwa Dr Rafal Czapiewski Tengfei Wan Amy Bell Kirsten Hill et al.	Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria	2016
Ammar Ashor Shakir Chowdhury Dr Clio Oggioni Othman Qadir Dr Kirsten Brandt et al.	Inorganic Nitrate Supplementation in Young and Old Obese Adults Does Not Affect Acute Glucose and Insulin Responses but Lowers Oxidative Stress	2016
Dr Clara Correia Melo Francisco Marques Rhys Anderson Dr Graeme Hewitt Dr Bernadette Carroll et al.	Mitochondria are required for pro-ageing features of the senescent phenotype	2016
Abbas Ishaq Dr Peter Hanson Dr Christopher Morris Dr Gabriele Saretzki	Telomerase Activity is Downregulated Early During Human Brain Development	2016
Dr Lili Zhu Dr Aurora Gomez Duran Dr Gabriele Saretzki Dr Katarzyna Tilgner Dario Melguizo Sanchis et al.	The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages	2016
Professor Bob Anderson Dr Simon Tual-Chalot Dr Rachael Redgrave Rebecca Dodds Dr Andrew Owens et al.	The role of cardiomyocyte senescence and regeneration in Ageing	2016
Professor Vijay Kunadian Dr Murugu Veerasamy Dr Hannah Sinclair Dr Jonathan Batty Meedya Sharifpour et al.	Association of Telomere Length and Telomerase Activity with Clinical Parameters in Older Patients Undergoing Invasive Management Of non-ST Elevation Acute Coronary Syndrome	2015
Dr Dean Hallam Dr Gabriele Saretzki	Dietary restriction mitigates age-related accumulation of DNA damage, but not all changes in mouse corneal epithelium	2015
Dr Alison Spilsbury Dr Satomi Miwa Professor Johannes Attems Dr Gabriele Saretzki	The Role of Telomerase Protein TERT in Alzheimer's Disease and in Tau-Related Pathology In Vitro	2015
Dr Karim Bennaceur Mark Atwill Nayef Al Zhrany Jedrzej Hoffmann Professor Bernard Keavney et al.	Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism	2014
Dr Diana Jurk Dr Caroline Wilson Dr Joao Passos Professor Fiona Oakley Clara Correia Melo et al.	Chronic inflammation induces telomere dysfunction and accelerates ageing in mice	2014
Nouf Al-Ajmi Dr Gabriele Saretzki Dr Colin Miles Professor Ioakim Spyridopoulos	Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbate the ageing phenotype	2014
Dr Satomi Miwa Dr Howsun Jow Karen Baty Amy Bell Dr Rafal Czapiewski et al.	Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice	2014
Dr Katarzyna Tilgner Dr Irina Neganova Sun Yung Chatcha Singhapol Dr Gabriele Saretzki et al.	A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors	2013
Dr Katarzyna Tilgner Dr Irina Neganova Chatcha Singhapol Dr Gabriele Saretzki Jerome Evans et al.	Brief Report: A Human Induced Pluripotent Stem Cell Model of Cernunnos Deficiency Reveals an Important Role for XLF in the Survival of the Primitive Hematopoietic Progenitors	2013
Sun Yung Dr Katarzyna Tilgner Dr Maria Ledran Dr Saba Habibollah Dr Irina Neganova et al.	Brief Report: Human Pluripotent Stem Cell Models of Fanconi Anemia Deficiency Reveal an Important Role for Fanconi Anemia Proteins in Cellular Reprogramming and Survival of Hematopoietic Progenitors	2013
Chatcha Singhapol Dr Deepali Pal Dr Rafal Czapiewski Dr Glyn Nelson Dr Gabriele Saretzki et al.	Mitochondrial Telomerase Protects Cancer Cells from Nuclear DNA Damage and Apoptosis	2013
Dr Conor Lawless Dr Diana Jurk Dr Colin Gillespie Dr Daryl Shanley Dr Gabriele Saretzki et al.	A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations	2012
Dr Yan Jiang Dr Katarzyna Tilgner Dr Gabriele Saretzki Professor Majlinda Lako Professor Lyle Armstrong et al.	Derivation and functional analysis of patient specific induced pluripotent stem cells (IPSCS) as an in vitro model of chronic granulomatous disease	2012
Dr Yan Jiang Dr Katarzyna Tilgner Dr Gabriele Saretzki Professor Majlinda Lako Professor Lyle Armstrong et al.	Derivation and Functional Analysis of Patient Specific Induced Pluripotent Stem Cells as an In Vitro Model of Chronic Granulomatous Disease	2012
Dr Yan Jiang Dr Katarzyna Tilgner Dr Gabriele Saretzki Professor Majlinda Lako Professor Lyle Armstrong et al.	Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease	2012
Marta Gorowiec Dr Lee Borthwick Dr Sean Parker Emeritus Professor John Kirby Dr Gabriele Saretzki et al.	Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-beta 1-dependent mechanism	2012
Avgi Tsolou Dr Glyn Nelson Dr Gabriele Saretzki Professor Thomas von Zglinicki	The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult	2012
Dr Gabriele Saretzki	Telomerase and Oxidative Stress in Embryonic Stem Cells	2011
Dr Gabriele Saretzki	Telomerase beyond telomeres: New roles for an Old Enzyme	2011
Mandy Maddick Dr Satomi Miwa Dr Diana Jurk Dr Rafal Czapiewski Dr Gabriele Saretzki et al.	Adult-onset, short-term dietary restriction reduces cell senescence in mice	2010
Dr Gabriele Saretzki	Cellular senescence in the development and treatment of cancer	2010
Dr Joao Passos Dr Glyn Nelson Dr Cedric Simillion Dr Carole Proctor Dr Satomi Miwa et al.	Feedback between p21 and reactive oxygen production is necessary for cell senescence	2010
Professor Lyle Armstrong Dr Katarzyna Tilgner Dr Gabriele Saretzki Dr Stuart Atkinson Professor Miodrag Stojkovic et al.	Human Induced Pluripotent Stem Cell Lines Show Stress Defense Mechanisms and Mitochondrial Regulation Similar to Those of Human Embryonic Stem Cells	2010
Dr Darren Daniels Dr Daniel Swan Dr Gabriele Saretzki	Immediate and gradual gene expression changes in telomerase over-expressing fibroblasts	2010
Dr Helen Tuppen Dr Vanessa Hogan Dr Langping He Dr Mazhor Aldosary Dr Gabriele Saretzki et al.	The p.M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple families	2010
Dr Gabriele Saretzki	Well-known signaling proteins exert new functions in the nucleus and mitochondria	2010
Dr Gabriele Saretzki	Telomerase, mitochondria and oxidative stress	2009
Dr Chunbo Yang Dr Rebecca Stewart Dr George Anyfantis Stuart Atkinson Dr Gabriele Saretzki et al.	A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation	2008
Dr Sean Parker Dr Lee Borthwick Professor Christopher Ward Dr James Lordan Dr Gabriele Saretzki et al.	Airway epithelial cell senescence in the lung allograft	2008
Dr Gabriele Saretzki Theresia Walter Dr Joao Passos Dr Rebecca Stewart Dr Simon Hoare et al.	Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells	2008
Dr Gabriele Saretzki Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki	Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length	2008
Marta Gorowiec Dr Lee Borthwick Marcin Pekalski Dr James Lordan Professor Christopher Ward et al.	Oxidative stress induces epithelial to mesenchymal transition in human lung epithelial cells through transforming groeth factor beta and integrin beta6-dependent mechanism	2008
Dr Saeed Ahmed Dr Joao Passos Matthew Birket Dr Heiko Peters Professor Mark Birch-Machin et al.	Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress	2008
Dr Joao Passos Dr Gabriele Saretzki Professor Thomas von Zglinicki	DNA damage in telomeres and mitochondria during cellular senescence: Is there a connection?	2007
Dr Gabriele Saretzki	Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart	2007
Professor Thomas von Zglinicki Dr Joao Passos Dr Gabriele Saretzki	Mitochondria and telomeres: Strange bedfellows in cell senescence	2007
Dr Joao Passos Dr Gabriele Saretzki Dr Saeed Ahmed Dr Glyn Nelson Torsten Richter et al.	Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence	2007
Marta Gorowiec Dr Sean Parker Dr Lee Borthwick Professor Christopher Ward Dr James Lordan et al.	Oxidative stress increases transforming growth factor-beta expression and drives epithelial to mesenchymal transition in human lung epithelial cells	2007
Dr Joao Passos Dr Glyn Nelson Dr Gabriele Saretzki Professor Thomas von Zglinicki	Oxygen free radicals in senescence: Are they signal transducers?	2007
Dr Joao Passos Dr Sharon Olijslagers Dr Gabriele Saretzki Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki et al.	Premature senescence of mesothelial cells is associated with non-telomeric DNA damage	2007
Dr Sean Parker Professor Christopher Ward Dr James Lordan Dr Gabriele Saretzki Professor Andrew Fisher et al.	Stress-induced premature senescence in airway epithelium and accelerated lung allograft aging	2007
Matthew Birket Professor Mark Birch-Machin Dr Saeed Ahmed Dr Gabriele Saretzki	Telomerase-dependent protection of mitochondrial DNA in response to oxidative stress	2007
Dr Sean Parker Marta Gorowiec Dr Lee Borthwick Dr James Lordan Professor Christopher Ward et al.	Transforming growth factor beta (TGF beta) induces cellular senescence in primary bronchial epithelial cells: A possible role in airway remodelling	2007
Dr Gabriele Saretzki Dr Glyn Nelson Dr Sharon Olijslagers Professor Thomas von Zglinicki	TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts	2007
Dr Joao Passos Dr Gabriele Saretzki Professor Thomas von Zglinicki	Mechanisms and role of oxidative damage to telomeres	2006
Dr Joao Passos Dr Gabriele Saretzki Professor Thomas von Zglinicki	Mechanisms and role of oxidative damage to telomeres	2006
Dr Joao Passos Professor Thomas von Zglinicki Dr Gabriele Saretzki	Mitochondrial dysfunction and cell senescence: Cause or consequence?	2006
Jessie Jeyapalan Dr Gabriele Saretzki Alan Leake Dr Michael Tilby Professor Thomas von Zglinicki et al.	Neuroblastoma cell apoptosis induction after cisplatin treatment is not telomere–dependent	2006
Dr Sean Parker Professor Christopher Ward Dr Fiona Black Dr James Lordan Dr Gabriele Saretzki et al.	Premature senescence of airway epithelial cells: A possible role in airway remodelling after human lung transplantation	2006
Jessie Jeyapalan Dr Gabriele Saretzki Alan Leake Dr Michael Tilby Professor Thomas von Zglinicki et al.	Tumour-cell apoptosis after cisplatin treatment is not telomere dependent	2006
Dr Gabriele Saretzki Dr Judith Hall	Endogenous and ectopic expression of telomere regulating genes in chicken embryonic fibroblasts	2005
Dr Gabriele Saretzki Dr Judith Hall	Endogenous and ectopic expression of telomere regulating genes in chicken embryonic fibroblasts	2005
Professor Thomas von Zglinicki Dr Gabriele Saretzki Susan Jackson	Human cell senescence as a DNA damage response	2005
Professor Lyle Armstrong Dr Gabriele Saretzki Dr Heiko Peters Ilka Wappler Dr Nicholas Hole et al.	Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage	2005
Professor Thomas von Zglinicki Dr Carmen Martin-Ruiz Dr Gabriele Saretzki	Telomeres, cell senescence and human ageing	2005
Dr Gabriele Saretzki	Telomeres, senescence and longevity: The role of oxidative stress and antioxidants	2005
Dr Gabriele Saretzki	The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo	2005
Professor Lyle Armstrong Professor Majlinda Lako Dr Gabriele Saretzki Dr Nicholas Hole	A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation	2004
Dr Carmen Martin-Ruiz Dr Gabriele Saretzki Jessie Jeyapalan Professor Thomas von Zglinicki	Stochastic Variation in Telomere Shortening Rate Causes Heterogeneity of Human Fibroblast Replicative Life Span	2004
Dr Gabriele Saretzki Professor Lyle Armstrong Alan Leake Professor Majlinda Lako Professor Thomas von Zglinicki et al.	Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells	2004
Barbara Keys Dr Gabriele Saretzki Professor Thomas von Zglinicki	Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3′-overhang	2004
Jessie Jeyapalan Alan Leake Dr Shaheda Ahmed Dr Gabriele Saretzki Dr Michael Tilby et al.	The role of telomeres in etoposide induced tumor cell death	2004
Professor Thomas von Zglinicki Dr Gabriele Saretzki Susan Jackson	A DNA damage checkpoint response in telomere-initiated senescence	2003
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Extracellular superoxide dismutase is a major antioxidant and slows down telomere shortening in human fibroblasts	2003
Professor Thomas von Zglinicki Dr Gabriele Saretzki	Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening	2003
Dr Barry Davies Islay Steele Professor Richard Edmondson Dr Simon Zwolinski Dr Gabriele Saretzki et al.	Immortalisation of human ovarian surface epithelium with telomerase and temperature-senstitive SV40 large T antigen	2003
Dr Gabriele Saretzki Professor Thomas von Zglinicki	MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress	2003
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Telomerase as a promising target for human cancer gene therapy	2003
Dr Gabriele Saretzki	Telomerase inhibition as cancer therapy	2003
Dr Gabriele Saretzki Professor Thomas von Zglinicki	hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines	2002
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Replicative aging, telomeres, and oxidative stress	2002
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Replicative aging, telomeres, and oxidative stress	2002
Dr Gabriele Saretzki Professor Thomas von Zglinicki	BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection	2001
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase	2001
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells	2001
Dr Gabriele Saretzki	Telomerase activity in cervical smears	2001
Professor Thomas von Zglinicki Dr Gabriele Saretzki	Regeneration der Telomeren als Basis zellulaerer Immortalitaet	2000
Professor Thomas von Zglinicki Dr Gabriele Saretzki	Short telomeres in patients with vascular dementia: An indicator of low antioxidative capacity and a possible risk factor?	2000
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Telomere length as a marker of oxidative stress in primary human fibroblast cultures	2000
Dr Gabriele Saretzki Professor Thomas von Zglinicki	[Replicative senescence as a model of aging: the role of oxidative stress and telomere shortening--an overview]	1999
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Modification of the replicative life-span of human fibroblasts by oxidative stress	1999
Professor Thomas von Zglinicki Dr Gabriele Saretzki	Ribozymes inhibiting the catalytic subunit of human telomerase (hTERT)	1999
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments	1999
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Telomeres and human aging	1999
Dr Gabriele Saretzki Professor Thomas von Zglinicki	Preferential accumulation of single-stranded regions in telomeres of human fibroblasts	1998