Publications by Emeritus Professor Bernard Golding - ePrints

Browsing publications by Emeritus Professor Bernard Golding.

Newcastle Authors	Title	Year
Dr Jay Tromans Bian Zhang Emeritus Professor Bernard Golding	Harnessing the Peterson Reaction for the Stereospecific Synthesis of Z-Vinyl Ethers	2024
Emeritus Professor Bernard Golding	The action of coenzyme B₁₂-dependent diol dehydratase on 3,3,3-trifluoro-1,2-propanediol results in elimination of all the fluorides with formation of acetaldehyde	2024
Dr Jay Tromans Dr Bian Zhang Emeritus Professor Bernard Golding	Unlocking nature's antioxidants: a novel method for synthesising plasmalogens	2024
Dr Jay Tromans Dr Bian Zhang Emeritus Professor Bernard Golding	1,4-Dimethoxynaphthalene-2-methyl (‘DIMON’), an oxidatively labile protecting group for synthesis of polyunsaturated lipids	2023
Professor William Watson Dr Tony Munter Emeritus Professor Bernard Golding	The effect of vitamin B12 on DNA adduction by styrene oxide, a genotoxic xenobiotic	2023
Melanie Uguen Gemma Davison James Hunter Dr Mathew Martin Dr Shannon Turberville et al.	Build–Couple–Transform: A paradigm for lead-like library synthesis with scaffold diversity	2022
Emeritus Professor Bernard Golding Manuel Abelairas-Edesa Daping Zhang Dr Alistair Henderson Dr Christine Bleasdale et al.	Influence of the methyl group in isoprene epoxides on reactivity compared to butadiene epoxides: Biological significance	2022
Duncan Miller Tristan Reuillon Dr Lauren Molyneux Dr Tim Blackburn Dr Noel Edwards et al.	Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor	2022
Islam Al-Khawaldeh Dr Christine Basmadjian Dr Cinzia Bordoni Dr Suzannah Harnor Amy Heptinstall et al.	An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase (NIK)	2021
Edwige Picazo Amy Heptinstall Dr Celine Cano Emeritus Professor Bernard Golding Professor Mike Waring et al.	Cyclisations and fragmentations in the alkylation of 6-chloro-5-hydroxy-4-aminopyrimidines with aminoalkyl chlorides	2021
Dr Marta Drozdowska Dr Jay Tromans Dr Bian Zhang Emeritus Professor Bernard Golding	Defining Pathways of Anaerobic Alkane Oxidation: Synthesis of Enantiomers of 4-Methylalkanoic Acids and (2-Methylalkyl)malonic Acids	2021
Miriam Fsadni Amy Roberts Professor Majid Sadeghi Emeritus Professor Bernard Golding	Enantiopure 2,9-Dideuterodecane – Preparation and Proof of Enantiopurity	2021
Dr Ian Hardcastle Dr Ruth Bawn Dr Tim Blackburn Dr Celine Cano Dr Sarah Cully et al.	Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction	2021
Christopher Matheson Christopher Coxon Dr Benoit Carbain Dr Ian Hardcastle Dr Suzannah Harnor et al.	2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase	2020
Dr Ahmad Al-Sheikh Masuma Begum Dr Bian Zhang Dr Richard Lewis Dr Nicholas Allenby et al.	Molecular Diversity via Tetrasubstituted Alkenes Containing a Barbiturate Motif: Synthesis and Biological Activity	2020
Stephanie Myers Duncan Miller Dr Lauren Molyneux Dr Mercedeh Arasta Dr Ruth Bawn et al.	Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4	2019
Dr Alistair Henderson Emeritus Professor Bernard Golding	Photochemistry of 2-butenedial and 4-oxo-2-pentenal under atmospheric boundary layer conditions	2019
Richard Espiritu Emeritus Professor Bernard Golding Emeritus Professor Keith Scott Professor Mohamed Mamlouk	Degradation of radiation grafted anion exchange membranes tethered with different amine functional groups via removal of vinylbenzyl trimethylammonium hydroxide	2018
Emeritus Professor Bernard Golding	Hydrogen Sulfide: A Reagent for pH-Driven Bioinspired 1,2-Diol Mono-deoxygenation and Carbonyl Reduction in Water	2018
Duncan Miller Dr Mathew Martin Santosh Adhikari Alfie Brennan Professor Jane Endicott et al.	Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach	2018
Emeritus Professor Bernard Golding Professor Mike Waring	The consequences of ‘Brexit’ for drug discovery and development, and the regulatory implications	2018
John Mullaney Dr Chris Medcraft Emeritus Professor Bernard Golding Dr Nick Walker Professor Anthony Legon et al.	Cooperative Hydrogen Bonds Form a Pseudocycle Stabilizing an Isolated Complex of Isocyanic Acid with Urea	2017
Christopher Coxon Dr Suzannah Harnor Dr Mathew Martin Dr Benoit Carbain Emeritus Professor Bernard Golding et al.	Cyclin-Dependent Kinase (CDK) Inhibitors; Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines	2017
Professor David Rees Emeritus Professor Bernard Golding Dr Ian Hardcastle Dr Celine Cano Duncan Miller et al.	ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY	2017
Professor David Rees Emeritus Professor Bernard Golding Dr Ian Hardcastle Dr Celine Cano Duncan Miller et al.	Preparation of isoindolinones as inhibitors of the MDM2-p53 interaction having anticancer activity	2017
Professor David Rees Emeritus Professor Bernard Golding Dr Ian Hardcastle Dr Celine Cano Duncan Miller et al.	Preparation of isoindolinones as inhibitors of the MDM2-p53 interaction having anticancer activity;WO 2017055860	2017
Dr Christopher Wong Dr Ian Hardcastle Christopher Matheson Professor Herbie Newell Dr Mangaleswaran Sivaprakasam et al.	Structure-guided design of purine-based probes for selective Nek2 inhibition	2017
Emeritus Professor Bernard Golding	The impact of Brexit on British science: Also Sprach Zunderland	2017
Christopher Coxon Dr Celine Cano Emeritus Professor Bernard Golding Professor Roger Griffin	A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase	2016
Emeritus Professor Bernard Golding	Anaerobic Degradation of p-Alkylated Benzoates and Toluenes	2016
Emeritus Professor Bernard Golding	Anaerobic Microbial Degradation of Hydrocarbons: From Enzymatic Reactions to the Environment	2016
Dr Gary Beale Dr Emma Haagensen Huw Thomas Lan Wang Charlotte Revill et al.	Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo anti-tumour activity in colorectal cancer	2016
Dr Victorovich Zaytsev James Pickles Dr Suzannah Harnor Dr Alistair Henderson Mohammed Al Yasiri et al.	Concise syntheses of bridged morpholines	2016
Emeritus Professor Bernard Golding	COST Action CM1201 "Biomimetic Radical Chemistry": free radical chemistry successfully meets many disciplines	2016
Tristan Reuillon Dr Sari Alhasan Dr Gary Beale Annalisa Bertoli Alfie Brennan et al.	Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases	2016
Dr Peter Friedrich Emeritus Professor Bernard Golding	Elucidating the stereochemistry of enzymatic benzylsuccinate synthesis with chirally labeled toluene	2016
Stephanie Myers Dr Ruth Bawn Betty Cottyn Dr Lauren Molyneux Dr Celine Cano et al.	High-throughput screening and hit validation of extracellular-related kinase 5 (ERK5) inhibitors	2016
Emeritus Professor Bernard Golding	Metabolism of Hydrocarbons in n-Alkane-Utilizing Anaerobic Bacteria	2016
Professor Roger Griffin Emeritus Professor Bernard Golding	New derivatives of the antimalarial drug Pyrimethamine in the control of melanoma tumor growth: an in vitro and in vivo study	2016
Xu Wang Emeritus Professor Bernard Golding Professor Eileen Yu Emeritus Professor Keith Scott	Preparation of a Chemically Stable Polysulfone-based Anion Exchange Membrane Using DABCO as the Quaternization Agent	2016
Tristan Reuillon Duncan Miller Stephanie Myers Dr Lauren Molyneux Dr Celine Cano et al.	Pyrrolcarboxamide Derivatives for the Inhibition of ERK5	2016
Emeritus Professor Bernard Golding	Structure and Function of 4-Hydroxyphenylacetate Decarboxylase and Its Cognate Activating Enzyme	2016
Emeritus Professor Bernard Golding	Structure and Function of Benzylsuccinate Synthase and Related Fumarate-Adding Glycyl Radical Enzymes	2016
Emeritus Professor Bernard Golding Dr Celine Cano	Synthesis and Biological Evaluation of N²-Substituted 2,4-Diamino-6-cyclohexylmethoxy-5-nitrosopyrimidines and Related 5-Cyano-NNO-azoxy Derivatives as Cyclin-Dependent Kinase 2 (CDK2) Inhibitors	2016
Emeritus Professor Bernard Golding	Academic medicinal chemistry: no country for young men (or women)?	2015
Emeritus Professor Bernard Golding	Corrin Synthesis via A→D Ring Closure. The Construction of A/D-Secocorrin Chromophore Systems by the ‘Sulfide Contraction’ Method and the Photochemical A/B-Secocorrin→Corrin Cycloisomerization	2015
Elisa Meschini Dr Regina Mora Vidal Dr Mathew Martin Dr Will Stanley Tristan Reuillon et al.	Identification and characterization of an irreversible inhibitor of CDK2	2015
Emeritus Professor Bernard Golding	Non-enzymatic Ribonucleotide Reduction in the Prebiotic Context	2015
Duncan Miller Dr Benoit Carbain Dr Gary Beale Dr Sari Alhasan Professor Helen Reeves et al.	Regioselective sulfamoylation at low temperature enables concise syntheses of putative small molecule inhibitors of sulfatases	2015
Dr Andrey Zaytsev Dr Barry Dodd Emeritus Professor Bernard Golding Professor Roger Griffin Dr Xiaohong Lu et al.	Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach	2015
Bian Zhang Emeritus Professor Bernard Golding Dr Ian Hardcastle	Small-molecule MDM2-p53 inhibitors: recent advances	2015
Andrew Shouksmith Laura Evans Professor Deborah Tweddle Duncan Miller Dr Elaine Willmore et al.	Synthesis and Activity of Putative Small-Molecule Inhibitors of the F-Box Protein SKP2	2015
Marta Drozdowska Emeritus Professor Bernard Golding	Versatile transformations of hydrocarbons in anaerobic bacteria: substrate ranges and regio- and stereo-chemistry of activation reactions	2015
Dr Benoit Carbain Dr Allyson Campbell Dr Celine Cano Professor Jane Endicott Emeritus Professor Bernard Golding et al.	8-Substituted O-6-Cyclohexylmethylguanine CDK2 Inhibitors: Using Structure-Based Inhibitor Design to Optimize an Alternative Binding Mode	2014
Emeritus Professor Bernard Golding	Alkylcobyrinate from sucralose and mechanistic aspects of its Co-C bond cleavage	2014
Alex Liu Dr Catherine Drummond Professor Jane Endicott Emeritus Professor Bernard Golding Professor Roger Griffin et al.	An X-ray crystal structure-based understanding of the inhibition of the MDM2-p53 protein-protein interaction by isoindolinones	2014
Marta Drozdowska Emeritus Professor Bernard Golding	Anaerobic Activation of p-Cymene in Denitrifying Betaproteobacteria: Methyl Group Hydroxylation versus Addition to Fumarate	2014
Honorine Lebraud Emeritus Professor Bernard Golding Elisa Meschini Dr Celine Cano Lan Wang et al.	Anticancer agents targeted against cyclin-dependent kinase 2 (CDK2): Structure-based design of irreversible and reversible inhibitors	2014
Andrew Shouksmith Laura Evans Professor Roger Griffin Emeritus Professor Bernard Golding Professor Herbie Newell et al.	Design and synthesis of putative small-molecule inhibitors targeting the SCFSKP2 E3 ligase complex	2014
Dr Ruth Bawn Tristan Reuillon Emeritus Professor Bernard Golding Professor Roger Griffin Dr Ian Hardcastle et al.	Development of extracellular signal-regulated kinase 5 (ERK5) inhibitors for anti-cancer therapy	2014
Dr Mathew Martin Elisa Meschini Lan Wang Dr Regina Mora Vidal Tristan Reuillon et al.	Identification and characterization of an irreversible inhibitor of CDK2	2014
Honorine Lebraud Christopher Coxon Vicky Archard Carlo Bawn Dr Benoit Carbain et al.	Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles	2014
Dr Susan Tudhope Dr Yan Zhao Dr Anita Wittner Annalisa Bertoli Santosh Adhikari et al.	Profiling inhibitors of MDM2: p53 and MDMX: p53 in relation to MDMX protein levels	2014
Emeritus Professor Bernard Golding	Sir John Warcup Cornforth (1917-2013)	2014
Dr Suzannah Harnor Dr Tommy Rennison Dr Martin Galler Dr Celine Cano Professor Roger Griffin et al.	Synthesis of 3 '-deoxy-3'-fluorothymidine (FLT) 5 '-O-glucuronide: a reference standard for imaging studies with [¹⁸F]FLT	2014
Dr Benoit Carbain Christopher Coxon Honorine Lebraud Dr Kris Elliott Christopher Matheson et al.	Trifluoroacetic Acid in 2,2,2-Trifluoroethanol Facilitates S_NAr Reactions of Heterocycles with Arylamines	2014
Annalisa Bertoli Santosh Adhikari Dr Suzannah Harnor Dr Yan Zhao Professor John Lunec et al.	Validation studies with small-molecule modulators of the MDM2/MDMX-p53 binding interaction	2014
Dr Celine Cano Dr Kappusamy Saravanan Professor Nicola Curtin Emeritus Professor Bernard Golding Dr Ian Hardcastle et al.	1-Substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones Endowed with Dual DNA-PK PI3-K Inhibitory Activity	2013
Emeritus Professor Bernard Golding	ATP-dependent/-independent enzymatic ring reductions involved in the anaerobic catabolism of naphthalene	2013
Dr Tommy Rennison Sonsoles Rodriguez-Aristegui Professor Nicola Curtin Emeritus Professor Bernard Golding Dr Ian Hardcastle et al.	Development of potent inhibitors of DNA-dependent protein kinase (DNA-PK)	2013
Dr Tim Blackburn Christopher Coxon Dr Xiaohong Lu Emeritus Professor Bernard Golding Professor Roger Griffin et al.	Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions	2013
Emeritus Professor Bernard Golding Marta Drozdowska	Metagenomic analysis and metabolite profiling of deep-sea sediments from the Gulf of Mexico following the Deepwater Horizon oil spill	2013
Sarah Cully Dr Celine Cano Emeritus Professor Bernard Golding Professor Roger Griffin Professor John Lunec et al.	Regiospecific synthesis of isoindolinones as MDM2 inhibitors	2013
Honorine Lebraud Dr Celine Cano Dr Benoit Carbain Dr Ian Hardcastle Dr Ross Harrington et al.	Trifluoroethanol solvent facilitates selective N-7 methylation of purines	2013
Dr Kelly Coffey Dr Tim Blackburn Susan Cook Emeritus Professor Bernard Golding Professor Roger Griffin et al.	Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer	2012
Tristan Reuillon Annalisa Bertoli Professor Roger Griffin Duncan Miller Emeritus Professor Bernard Golding et al.	Efficacious N-protection of O-aryl sulfamates with 2,4-dimethoxybenzyl groups	2012
Dr Peter Friedrich Dr Ulrich Baisch Dr Ross Harrington Frederick Lyatuu Emeritus Professor William McFarlane et al.	Experimental Study of Hydrogen Bonding Potentially Stabilizing the 5'-Deoxyadenosyl Radical from Coenzyme B12	2012
Dr Peter Friedrich Emeritus Professor Bernard Golding	Hydrogen Bonds Guide the Short-Lived 5 '-Deoxyadenosyl Radical to the Place of Action	2012
Emeritus Professor Bernard Golding Professor Roger Griffin	Mechanism-based design, synthesis and biological studies of N-5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents	2012
Dr Tommy Rennison Faye Craven Emeritus Professor Bernard Golding Professor Roger Griffin Dr Karen Haggerty et al.	Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives	2012
Emeritus Professor Bernard Golding	Revisiting the reaction of hydroxyl radicals with vicinal diols in water	2012
Professor Majid Sadeghi Marta Drozdowska Dr Sven Lahme Emeritus Professor Bernard Golding	Stereochemical Investigations Reveal the Mechanism of the Bacterial Activation of n-Alkanes without Oxygen	2012
Dr Richard Scott Kristin Downey Dr Keith Healy Dr Alistair Henderson Claire Robinson et al.	Synthesis and stability of 3-hydroxyanagrelide, a biologically potent metabolite of anagrelide	2012
Xu Wang Emeritus Professor Bernard Golding Professor Majid Sadeghi Dr Yuancheng Cao Emeritus Professor Keith Scott et al.	A novel phosphoric acid loaded quaternary 1,4-diazabicyclo-[2.2.2]-octane polysulfone membrane for intermediate temperature fuel cells	2011
Emeritus Professor Bernard Golding Professor Majid Sadeghi Dr Yuancheng Cao Professor Eileen Yu Emeritus Professor Keith Scott et al.	A polytetrafluoroethylene-quaternary 1,4-diazabicyclo-[2.2.2]-octane polysulfone composite membrane for alkaline anion exchange membrane fuel cells	2011
Hitesh Motwani Emeritus Professor Bernard Golding	Cob(I)alamin reacts with sucralose to afford an alkylcobalamin: Relevance to in vivo cobalamin and sucralose interaction	2011
Dr Kate Smith Emeritus Professor Bernard Golding Elizabeth Griffin Professor Roger Griffin Dr Ian Hardcastle et al.	DNA-dependent protein kinase (DNA-PK) inhibitors: Structure–activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain	2011
Dr Philip Butler Emeritus Professor Bernard Golding Dr Gilles Laval Dr Hosein Loghmani-Khouzani Professor Majid Sadeghi et al.	Fluorination and chlorination of nitroalkyl groups (vol 63, pg 11160, 2007) [Addendum]	2011
Emeritus Professor Bernard Golding	Identification and Characterization of 2 '-Deoxyadenosine Adducts Formed by Isoprene Monoepoxides in Vitro	2011
Dr Ian Hardcastle Alex Liu Dr Eric Valeur Anna Watson Shafiq Ahmed et al.	Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein-Protein Interaction: Structure-Activity Studies Leading to Improved Potency	2011
Dr Karim Bennaceur Dr Catherine Drummond Professor Jane Endicott Emeritus Professor Bernard Golding Professor Roger Griffin et al.	MDM2-p53 protein-protein interaction inhibitors: A-ring substituted isoindolinones	2011
Emeritus Professor Bernard Golding	Molecular hijacking of siroheme for the synthesis of heme and d(1) heme	2011
Dr Kappusamy Saravanan Hannah Barlow Marion Barton Professor Hilary Calvert Emeritus Professor Bernard Golding et al.	Nucleoside Transport Inhibitors: Structure-Activity Relationships for Pyrimido[5,4-d]pyrimidine Derivatives That Potentiate Pemetrexed Cytotoxicity in the Presence of α₁-Acid Glycoprotein	2011
Huw Thomas Dr Celine Roche Dr Johanne Bentley Dr Ian Hardcastle Emeritus Professor Bernard Golding et al.	Preclinical in vitro and in vivo evaluation of the potent and specific cyclin-dependent kinase 2 inhibitor NU6102 and a water soluble prodrug NU6301	2011
Sonsoles Rodriguez-Aristegui Dr Lauren Molyneux Dr Celine Cano Dr Marine Desage-El-Murr Professor Roger Griffin et al.	Versatile Synthesis of Functionalised Dibenzothiophenes via Suzuki Coupling and Microwave-assisted Ring Closure	2011
Dr Celine Cano Emeritus Professor Bernard Golding Dr Karen Haggerty Dr Ian Hardcastle Professor Roger Griffin et al.	Atropisomeric 8-arylchromen-4-ones exhibit enantioselective inhibition of the DNA-dependent protein kinase (DNA-PK)	2010
Elisa Meschini Professor Jane Endicott Emeritus Professor Bernard Golding Dr Ian Hardcastle Professor Herbie Newell et al.	Design and synthesis of dual CDK2 and CDK7 inhibitors	2010
Dr Kate Smith Dr Tommy Rennison Sonsoles Rodriguez-Aristegui Professor Nicola Curtin Emeritus Professor Bernard Golding et al.	Development of potent inhibitors of DNA-dependent protein kinase (DNA-PK)	2010
Dr Celine Cano Dr Olivier Barbeau Professor Nicola Curtin Emeritus Professor Bernard Golding Dr Ian Hardcastle et al.	DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype	2010
Sara Payne Sonsoles Rodriguez-Aristegui Dr Celine Cano Emeritus Professor Bernard Golding Dr Ian Hardcastle et al.	Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors	2010
Emeritus Professor Bernard Golding Martine Barnes Dr Christine Bleasdale Dr Alistair Henderson Dong Jiang et al.	Modeling the formation and reactions of benzene metabolites	2010
Dr Benoit Carbain Dr Celine Roche Emeritus Professor Bernard Golding Dr Ian Hardcastle Dr Celine Cano et al.	Structure-based design of C8-substituted O6-alkylguanine CDK1 and 2 inhibitors	2010
Dr Francesco Marchetti Dr Celine Cano Professor Nicola Curtin Emeritus Professor Bernard Golding Professor Roger Griffin et al.	Synthesis and biological evaluation of 5-substituted O⁴-alkylpyrimidines as CDK2 inhibitors	2010
Dr Christopher Wong Professor Roger Griffin Dr Ian Hardcastle Dr Julian Scott Northen Lan Wang et al.	Synthesis of sulfonamide-based kinase inhibitors from sulfonates by exploiting the abrogated S_N2 reactivity of 2,2,2-trifluoroethoxysulfonates	2010
Diana Suarez Dr Gilles Laval Shang-Min Tu Dong Jiang Claire Robinson et al.	Benzylic Brominations with N-Bromosuccinimide in (Trifluoromethyl)benzene	2009
Hitesh Motwani Emeritus Professor Bernard Golding	Cob(I)alamin for Trapping Butadiene Epoxides in Metabolism with Rat S9 and for Determining Associated Kinetic Parameters	2009
Emeritus Professor Bernard Golding Antonius Pierik	Crystal Structure and Putative Mechanism of 3-Methylitaconate-Delta-isomerase from Eubacterium barkeri	2009
Huw Thomas Dr Kappusamy Saravanan Lan Wang Mei Lin Dr Julian Scott Northen et al.	Preclinical evaluation of a novel pyrimidopyrimidine for the prevention of nucleoside and nucleobase reversal of antifolate cytotoxicity	2009
Professor Herbie Newell Huw Thomas Lan Wang Dr Celine Roche Dr Ian Hardcastle et al.	[abstract] Preclinical in vitro and in vivo evaluation of the cyclin dependent kinase 2 inhibitor NU6102 and a water pro-drug NU6301	2008
Dr Celine Cano Emeritus Professor Bernard Golding Dr Ian Hardcastle Professor Nicola Curtin Professor Roger Griffin et al.	8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK)	2008
Professor Jane Endicott Stuart Kemp Dr Lucy Smyth Dr Eric Valeur Emeritus Professor Bernard Golding et al.	Analysis of Chemical Shift Changes Reveals the Binding Modes of Isoindolinone Inhibitors of the MDM2-p53 Interaction	2008
Emeritus Professor Bernard Golding	Biologically relevant small radicals	2008
Antonius Pierik Emeritus Professor Bernard Golding	But-3-ene-1,2-diol: A Mechanism-Based Active Site Inhibitor for Coenzyme B-12-Dependent Glycerol Dehydratase	2008
Dr Celine Cano Professor Nicola Curtin Emeritus Professor Bernard Golding Dr Karen Haggerty Dr Ian Hardcastle et al.	Development of Potent Water-soluble Inhibitors of DNA-Dependent Protein Kinase (DNA-PK)	2008
Dr Kappusamy Saravanan Dr Celine Cano Professor Nicola Curtin Emeritus Professor Bernard Golding Dr Karen Haggerty et al.	Identification of potent water-soluble DNA-dependent protein kinase (DNA-PK) inhibitors using a small-molecule library approach [abstract]	2008
Dr Xiaomei Lu Alex Liu Dr Ian Hardcastle Professor Roger Griffin Emeritus Professor Bernard Golding et al.	MDM2 and MDMX status as a determinant of in vitro cellular sensitivity to MDM2 antagonists in human tumour cell lines	2008
Emeritus Professor Bernard Golding	Mechanism of Enzymatic Birch Reduction: Stereochemical Course and Exchange Reactions of Benzoyl-CoA Reductase	2008
Emeritus Professor Bernard Golding Professor Roger Griffin Dr Claire Hutton Professor John Lunec Professor Herbie Newell et al.	MEDI 147-Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction	2008
Emeritus Professor Bernard Golding	The Complete Stereochemistry of the Enzymatic Dehydration of 4-Hydroxybutyryl Coenzyme A to Crotonyl Coenzyme A	2008
Sonja Seeberger Professor Roger Griffin Dr Ian Hardcastle Emeritus Professor Bernard Golding	A new strategy for the synthesis of taurine derivatives using the 'safety-catch' principle for the protection of sulfonic acids	2007
Dr Tony Munter Rikas Ghai Emeritus Professor Bernard Golding Professor William Watson	Erratum to "The metabolism and molecular toxicology of chloroprene" [Chem. Biol. Interact. 166 (1-3) (2007) 323-331] (DOI:10.1016/j.cbi.2006.05.017)	2007
Philip Butler Emeritus Professor Bernard Golding Dr Gilles Laval Dr Hosein Loghmani-Khouzani Professor Majid Sadeghi et al.	Fluorination and chlorination of nitroalkyl groups	2007
Jonathan Hollick Dr Laurent Rigoreau Dr Celine Cano Professor Nicola Curtin Emeritus Professor Bernard Golding et al.	Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase	2007
Dr Olivier Barbeau Dr Celine Cano Professor Roger Griffin Dr Ian Hardcastle Professor William Clegg et al.	Quinolinone and pyridopyrimidinone inhibitors of DNA-dependent protein kinase	2007
Dr Francesco Marchetti Kerry Louise Sayle Dr Johanne Bentley Professor William Clegg Professor Nicola Curtin et al.	Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6- aminopyrimidine inhibitors of cyclin-dependent kinase 2	2007
Dr Tony Munter Rikas Ghai Emeritus Professor Bernard Golding Professor William Watson	The metabolism and molecular toxicology of chloroprene	2007
Professor Majid Sadeghi Dr Hosein Loghmani-Khouzani Emeritus Professor Bernard Golding	Erratum to "Sonochemical fluorination of heterocyclic nitro compounds with Selectfluor™ (F-TEDA-BF4)". [Tetrahedron Lett. 47 (2006) 2455]	2006
Professor Majid Sadeghi Dr Hosein Loghmani-Khouzani Dr Philip Butler Emeritus Professor Bernard Golding	Erratum: Sonochemical fluorination of heterocyclic nitro compounds with Selectfluor	2006
Emeritus Professor Bernard Golding	Insights into the hydrogen-abstraction reactions of diol dehydratase: Relevance to the catalytic mechanism and suicide inactivation	2006
Emeritus Professor Bernard Golding Professor Roger Griffin Dr Ian Hardcastle	Judicious application of allyl protecting groups for the synthesis of 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl triflate, a key precursor of DNA-dependent protein kinase inhibitors	2006
Emeritus Professor Bernard Golding	Lars Ehrenberg (1921-2005) - Obituary	2006
Antonius Pierik Diana Suarez Shang-Min Tu Emeritus Professor Bernard Golding	Mechanism-based inactivation of coenzyme B12-dependent 2-methyleneglutarate mutase by (Z)-glutaconate and buta-1,3-diene-2,3- dicarboxylate	2006
Emeritus Professor Bernard Golding	Radical enzymes in anaerobes	2006
Professor Roger Griffin Andrew Henderson Professor Nicola Curtin Professor Jane Endicott Dr Ian Hardcastle et al.	Searching for cyclin-dependent kinase inhibitors using a new variant of the cope elimination	2006
Dr Ian Hardcastle Dr Shafiq Ahmed Helen Atkins Gillian Farnie Emeritus Professor Bernard Golding et al.	Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold	2006
Professor Majid Sadeghi Dr Hosein Loghmani-Khouzani Emeritus Professor Bernard Golding	Sonochemical fluorination of heterocyclic nitro compounds with Selectfluor (TM) (F-TEDA-BF4) (vol 47, pg 2455, 2006)	2006
Professor Majid Sadeghi Dr Hosein Loghmani-Khouzani Emeritus Professor Bernard Golding	Sonochemical fluorination of heterocyclic nitro compounds with Selectfluor™ (F-TEDA-BF4)	2006
Emeritus Professor Bernard Golding	Stabilisation of methylene radicals by Cob(II)alamin in coenzyme B₁₂ dependent mutases	2006
Dr Olivier Barbeau Emeritus Professor Bernard Golding Professor Roger Griffin Dr Ian Hardcastle	Design and synthesis of novel DNA-dependent protein kinase (DNA-PK) inhibitors	2005
Professor Roger Griffin Dr Olivier Barbeau Emeritus Professor Bernard Golding Dr Ian Hardcastle	Design and synthesis of novel pyridopyrimidin-4-one and quinolin-4-one DNA-dependent protein kinase (DNA-PK) inhibitors	2005
Dr Ian Hardcastle Professor Nicola Curtin Justin John James Leahy Martin Stockley Emeritus Professor Bernard Golding et al.	Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach	2005
Dr Olivier Barbeau Professor Roger Griffin Dr Ian Hardcastle Emeritus Professor Bernard Golding	Efficient synthesis of 8-substituted 2-morpholine-4-yl-quinolin-4-ones: Potent inhibitors of DNA-dependent protein kinase	2005
Dr Alistair Henderson Dr Christine Bleasdale Emeritus Professor Bernard Golding	Evidence for the formation of Michael adducts from reactions of (E,E)-muconaldehyde with glutathione and other thiols	2005
Emeritus Professor Bernard Golding	Facile cobalt(III) template synthesis of novel branched hexadentate polyamine monocarboxylates	2005
Dr Alistair Henderson Emeritus Professor Bernard Golding	In vitro studies of the influence of glutathione transferases and epoxide hydrolase on the detoxification of acrylamide and glycidamide in blood	2005
Dr Ian Hardcastle Shafiq Ahmed Emeritus Professor Bernard Golding Professor Roger Griffin Dr Claire Hutton et al.	Inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold	2005
Stuart Kemp Dr Ian Hardcastle Dr Shafiq Ahmed Emeritus Professor Bernard Golding Professor Roger Griffin et al.	Isoindolinone based inhibitors of the MDM2-p53 protein-protein interaction	2005
Dr Ian Hardcastle Dr Shafiq Ahmed Professor Alan Calvert Professor Nicola Curtin Gillian Farnie et al.	Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction	2005
Professor Roger Griffin Dr YuZhu Cheng Professor Nicola Curtin Emeritus Professor Bernard Golding Dr Ian Hardcastle et al.	Potent CDK2 inhibitors generated using a variant of the cope elimination	2005
Dr Allyson Campbell Dr YuZhu Cheng Lan Wang Professor Nicola Curtin Emeritus Professor Bernard Golding et al.	Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: A possible role for survivin down-regulation	2005
Dr Alastair Hayes Emeritus Professor Bernard Golding	Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026	2005
Emeritus Professor Bernard Golding	Radical-mediated dehydration reactions in anaerobic bacteria	2005
Dr Virginia Silvari Emeritus Professor Bernard Golding	Reaction-kinetic parameters of glycidamide as determinants of mutagenic potency	2005
Martine Barnes Dr Christine Bleasdale Professor William Clegg Professor William Watson Emeritus Professor Bernard Golding et al.	Reactions of benzene oxide with thiols including glutathione	2005
Antonius Pierik Daniele Ciceri Emeritus Professor Bernard Golding	Searching for intermediates in the carbon skeleton rearrangement of 2-methyleneglutarate to (R)-3-methylitaconate catalyzed by coenzyme B 12-dependent 2-methyleneglutarate mutase from Eubacterium barkeri	2005
Emeritus Professor Bernard Golding Dr Ian Hardcastle Professor Roger Griffin	Searching for potent CDK inhibitors using a new variant of the Cope elimination	2005
Andrew Henderson Dr YuZhu Cheng Professor Nicola Curtin Emeritus Professor Bernard Golding Professor Roger Griffin et al.	Searching for potent CDK2 inhibitors using a variant of the Cope elimination	2005
Professor Roger Griffin Emeritus Professor Bernard Golding Sophie Guiard Dr Ian Hardcastle Justin John James Leahy et al.	Selective benzopyranone and pyrimido[2,1-alpha]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: Synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro	2005
Antonius Pierik Emeritus Professor Bernard Golding	Synthesis of 13C-labeled γ-hydroxybutyrates for EPR studies with 4-hydroxybutyryl-CoA dehydratase	2005
Professor William Clegg Emeritus Professor Bernard Golding Dr Ross Harrington Dr Richard Scott	1-{2-[4-(2,4-Dinitrophenyl)piperazin-1 -yl]ethyl}-4-aza-1-azoniabicyclo[2. 2.2]octane chloride	2004
Dr Alistair Henderson Dr Christine Bleasdale Professor William Clegg Emeritus Professor Bernard Golding	2,6-Diarylaminotetrahydropyrans from Reactions of Glutaraldehyde with Anilines: Models for Biomolecule Cross-Linking	2004
Professor William Watson Dr Tony Munter Emeritus Professor Bernard Golding	A new role for glutathione: Protection of vitamin B₁₂ from depletion by xenobiotics	2004
Dr Alistair Henderson Emeritus Professor Bernard Golding	Adducts of N-terminal valines in hemoglobin with isoprene diepoxide, a metabolite of isoprene	2004
Emeritus Professor Bernard Golding	Coenzyme B12-dependent enzymatic dehydration of 1,2-diols: Simple reaction, complex mechanism!	2004
Dr Christopher Calabrese Professor Nicola Curtin Suzanne Kyle Huw Thomas Lan Wang et al.	Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1- hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase	2004
Dr Tony Munter Emeritus Professor Bernard Golding Professor William Watson	DNA reactivity and detoxication pathways of chloroprene metabolites in vitro	2004
Dr Raghuram Chetty Professor Paul Christensen Emeritus Professor Bernard Golding Emeritus Professor Keith Scott	Fundamental and applied studies on the electrochemical hydrodehalogenation of halogenated phenols at a palladised titanium electrode	2004
Justin John James Leahy Emeritus Professor Bernard Golding Professor Roger Griffin Dr Ian Hardcastle Dr Laurent Rigoreau et al.	Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries	2004
Dr Richard Scott Emeritus Professor Bernard Golding	Improved synthesis of enantiomerically pure Etomoxir and its 2,4-dinitrophenyl analogue	2004
Dr Ian Hardcastle Dr Christine Arris Dr Johanne Bentley Professor Nicola Curtin Professor Jane Endicott et al.	N2-substituted O6-cyclohexylmethylguanine derivatives: Potent inhibitors of cyclin-dependent kinases 1 and 2	2004
Emeritus Professor Bernard Golding	Optimisation of the synthesis of guanidines from amines via nitroguanidines using 3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine	2004
Professor Nicola Curtin Emeritus Professor Bernard Golding Suzanne Kyle Professor Roger Griffin	Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors	2004
Professor Nicola Curtin Hannah Barlow Professor Alan Calvert Richard Davison Emeritus Professor Bernard Golding et al.	Resistance-modifying agents. 11. Pyrimido[5,4-d]pyrimidine modulators of antitumor drug activity. Synthesis and structure-activity relationships for nucleoside transport inhibition and binding to α₁-acid glycoprotein	2004
Emeritus Professor Bernard Golding	Stereochemistry of hydrogen removal from the 'unactivated' C-3 position of 4-hydroxybutyryl-CoA catalysed by 4-hydroxybutyryl-CoA dehydratase	2004
Daping Zhang Emeritus Professor Bernard Golding	Synthesis, characterization, and identification of N7-guanine adducts of isoprene monoepoxides in vitro	2004
Dr Kieren Carey Professor William Clegg Dr Mark Elsegood Emeritus Professor Bernard Golding	1,2-Bis[bis(4-methoxyphenyl)hydroxymethyl]benzene	2003
Dr Kieren Carey Professor William Clegg Dr Mark Elsegood Emeritus Professor Bernard Golding	1,2-Bis[bis(4-methoxyphenyl)hydroxymethyl]benzene	2003
Jonathan Hollick Emeritus Professor Bernard Golding Dr Ian Hardcastle Dr Laurent Rigoreau Professor Roger Griffin et al.	2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-dependent protein kinase (DNA-PK)	2003
Dr Veronique Mesguiche Rachel Parsons Dr Christine Arris Dr Johanne Bentley Professor Nicola Curtin et al.	4-Alkoxy-2,6-diaminopyrimidine derivatives: Inhibitors of cyclin dependent kinases 1 and 2	2003
Antonius Pierik Emeritus Professor Bernard Golding	Acryloyl-CoA reductase from Clostridium propionicum: An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein	2003
Dr Tony Munter Emeritus Professor Bernard Golding Professor William Watson	Detoxication Pathways Involving Glutathione and Epoxide Hydrolase in the in Vitro Metabolism of Chloroprene	2003
Hayley Whitfield Professor Roger Griffin Dr Ian Hardcastle Dr Alistair Henderson Dr Jerome Meneyrol et al.	Facilitation of addition-elimination reactions in pyrimidines and purines using trifluoroacetic acid in trifluoroethanol	2003
Emeritus Professor Bernard Golding	Identification of adducts formed by the reaction of isoprene monoepoxides with 2'-deoxyadenosine	2003
Dr Raghuram Chetty Professor Paul Christensen Emeritus Professor Bernard Golding	In situ FTIR studies on the electrochemical reduction of halogenated phenols	2003
Dr Alistair Henderson Emeritus Professor Bernard Golding	Induction of micronuclei in mouse and rat by glycidamide, genotoxic metabolite of acrylamide	2003
Dr Alistair Henderson Emeritus Professor Bernard Golding	Measurements of photo-oxidation products from the reaction of a series of alkyl-benzenes with hydroxyl radicals during EXACT using comprehensive gas chromatography	2003
Emeritus Professor Bernard Golding Professor William Watson	Stereochemical and kinetic comparisons of mono- and diepoxide formation in the in vitro metabolism of isoprene by liver microsomes from rats, mice, and humans	2003
Professor William Clegg Dr Ross Harrington Emeritus Professor Bernard Golding	Stereocontrolled Synthesis of (2R,3S)-2-Methylisocitrate, a Central Intermediate in the Methylcitrate Cycle	2003
Kerry Louise Sayle Dr Johanne Bentley Professor Alan Calvert Dr YuZhu Cheng Professor Nicola Curtin et al.	Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2	2003
Professor Nicola Curtin Professor Herbie Newell Professor Alan Calvert Professor Roger Griffin Emeritus Professor Bernard Golding et al.	Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors	2003
Kerry Louise Sayle Dr Veronique Mesguiche Rachel Parsons Professor Jane Endicott Professor Martin Noble et al.	4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2	2002
Daniele Ciceri Emeritus Professor Bernard Golding	A novel reaction between adenosylcobalamin and 2-methyleneglutarate catalyzed by glutamate mutase	2002
Jonathan Hollick Emeritus Professor Bernard Golding Professor Roger Griffin Dr Ian Hardcastle Justin John James Leahy et al.	Application of combinatorial chemistry for the identification of pyran-4-one and thiopyran-4-one inhibitors of DNA-dependent protein kinase	2002
Dr Gilles Laval Professor William Clegg Emeritus Professor Bernard Golding	Assembly of polyamines via amino acids from three components using cobalt(III) template methodology	2002
Professor Roger Griffin Dr Ian Hardcastle Dr Laurent Rigoreau Martin Stockley Justin John James Leahy et al.	Cassette dosing iv and ip of novel DNA dependent protein kinase inhibitors	2002
Dr Julian Scott Northen Professor William Clegg Professor Nicola Curtin Professor Roger Griffin Emeritus Professor Bernard Golding et al.	Controlled stepwise conversion of 2,4,6,8-tetrachloropyrimido-[5,4-d ]pyrimidine into 2,4,6,8-tetrasubstituted pyrimido[5,4-d]pyrimidines	2002
Dr Ian Hardcastle Emeritus Professor Bernard Golding Professor Roger Griffin	Designing inhibitors of cyclin-dependent kinases	2002
Dr Alistair Henderson Emeritus Professor Bernard Golding	Evidence for phosphate adducts in DNA from mice treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)	2002
Professor Roger Griffin Dr Ian Hardcastle Dr Laurent Rigoreau Martin Stockley Justin John James Leahy et al.	High throughput pharmacokinetics of novel DNA-dependent protein kinase inhibitors	2002
Dr Tony Munter Professor William Watson Emeritus Professor Bernard Golding	Identification of adducts derived from reactions of (1-chloroethenyl)oxirane with nucleosides and calf thymus DNA	2002
Dr Christopher Calabrese Professor Nicola Curtin Suzanne Kyle Huw Thomas Lan Wang et al.	Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis, and X-ray cocrystal structure	2002
Dr Ashleigh Gibson Dr Christine Arris Dr Johanne Bentley Professor Nicola Curtin Professor Jane Endicott et al.	Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O6-substituted guanine derivatives	2002
Antonius Pierik Daniele Ciceri Emeritus Professor William McFarlane John Winter Emeritus Professor Bernard Golding et al.	Rotation of the exo-methylene group of (R)-3-methylitaconate catalyzed by coenzyme B12-dependent 2-methyleneglutarate mutase from Eubacterium barkeri	2002
Dr Johanne Bentley Dr Christine Arris Professor Nicola Curtin Professor Jane Endicott Dr Ashleigh Gibson et al.	Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor	2002
Dr Philip Butler Emeritus Professor Bernard Golding	Synthesis of 2-(nitromethyl)ornithine from ornithine mediated by cobalt(III)	2002
Dr Kieren Carey Professor William Clegg Dr Mark Elsegood Emeritus Professor Bernard Golding Dr Maurice Hill et al.	Synthesis of highly hindered oxepins and an azepine from bis-trityl carbenium ions: structural characterisation by NMR and X-ray crystallography	2002
Dr Alistair Henderson Esra Mutlu Dr Christine Bleasdale Professor William Clegg Professor Richard Henderson et al.	Trapping of benzene oxide-oxepin and methyl-substituted derivatives with 4-phenyl- and 4-pentafluorophenyl-1,2,4-triazoline-3,5-dione	2002
Professor Nicola Curtin Dr Stephen Barton Michael Batey Dr Christopher Calabrese Professor Alan Calvert et al.	Anti-cancer chemosensitization in vitro and in vivo by a novel potent poly(ADP-ribose) polymerase (PARP1) inhibitor, TBI-361.	2001
Dr Alistair Henderson Emeritus Professor Bernard Golding	Crossed acyloin condensation of aliphatic aldehydes	2001
Peter Smith Huw Thomas Hannah Barlow Professor Roger Griffin Emeritus Professor Bernard Golding et al.	In vitro and in vivo properties of novel nucleoside transport inhibitors with improved pharmacological properties that potentiate antifolate activity	2001
Emeritus Professor Bernard Golding Dr Tony Munter Professor William Watson	In vitro metabolism of chloroprene: Species differences, epoxide stereochemistry and a de-chlorination pathway	2001
Professor Alan Calvert Professor Nicola Curtin Emeritus Professor Bernard Golding Professor Roger Griffin Dr Ian Hardcastle et al.	Inhibiting the MDM2-p53 interaction using low molecular weight compounds	2001
Emeritus Professor Bernard Golding	Interconversion of (S)-glutamate and (2S,3S)-3-methylaspartate: A distinctive B-12-dependent carbon-skeleton rearrangement	2001
Professor William Watson Emeritus Professor Bernard Golding	Metabolism and molecular toxicology of isoprene	2001
Dr Stephany Veuger Professor barbara Durkacz Emeritus Professor Bernard Golding Professor Roger Griffin Professor Herbie Newell et al.	Radiosensitization by novel inhibitors of PARP, PI, and DNA-PK, NU7026, in vitro	2001
Professor Martin Noble Dr Christine Arris Professor Alan Calvert Professor Nicola Curtin Dr Ashleigh Gibson et al.	Structural and thermodynamic validation of inactive cdk2 as a template for structure-based drug design	2001
Professor Martin Noble Dr Christine Arris Professor Alan Calvert Professor Nicola Curtin Emeritus Professor Bernard Golding et al.	Structure based design of a potent inhibitor of cdk2	2001
Emeritus Professor Bernard Golding	Study on synthesis of ethyl 3-oxo-(S)-(+)-6,7-di-O-isopropylidene-6,7-dihydroxyheptanoate	2001
Martin Stockley Professor William Clegg Emeritus Professor Bernard Golding Nicola Martin Dr Laurent Rigoreau et al.	Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035)	2001
Peter Smith Huw Thomas Hannah Barlow Professor Roger Griffin Emeritus Professor Bernard Golding et al.	In vitro activity and in vivo pharmacology of two novel nucleoside transport inhibitors, NU3108 and NU3121	2000
Dr Minyan Wang Emeritus Professor Bernard Golding	A convenient preparation of p-methoxybenzyl esters	2000
Emeritus Professor Bernard Golding	Atmospheric chemistry of toluene-1,2-oxide/2-methyloxepin	2000
Professor Nicola Curtin Professor Alan Calvert Professor barbara Durkacz Professor Roger Griffin Emeritus Professor Bernard Golding et al.	Chemopotentiation studies with two classes of potent (polyADP-ribose) polymerase (PARP) inhibitors in human lung and colon carcinoma cell lines.	2000
Dr Christopher Calabrese Professor Nicola Curtin Michael Batey Huw Thomas Suzanne Kyle et al.	Design and evaluation of novel potent inhibitors of poly (ADP-ribose) polymerase	2000
Professor Roger Griffin Dr Christine Arris Professor Alan Calvert Professor Nicola Curtin Dr Ashleigh Gibson et al.	Design, synthesis, and biological evaluation of O-6-alkylguanine and O-4-alkylpyrimidine cyclin-dependent kinase inhibitors	2000
Dr Christine Arris Professor Alan Calvert Professor Nicola Curtin Dr Ashleigh Gibson Emeritus Professor Bernard Golding et al.	Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles	2000
Dr Christine Arris Professor Alan Calvert Professor Nicola Curtin Professor Jane Endicott Emeritus Professor Bernard Golding et al.	Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles	2000
Emeritus Professor Bernard Golding	Intramolecular functionalisation by a methylene radical of a 1,2-diol and a vicinal amino alcohol: Models for coenzyme B12-dependent diol dehydratase and ethanolamine ammonia lyase	2000
Dr Christine Arris Professor Alan Calvert Professor Nicola Curtin Emeritus Professor Bernard Golding Professor Roger Griffin et al.	O6-substituted guanines and 4-substituted pyrimidines: a novel class of antiproliferative cyclin dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.	2000
Professor Roger Griffin Dr Christine Arris Dr Christine Bleasdale Professor Alan Calvert Professor Nicola Curtin et al.	Resistance-modifying agents. 8. Inhibition of O⁶-alkylguanine-DNA alkyltransferase by O⁶-alkenyl-, O⁶-cycloalkenyl-, and O⁶-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O⁶-(1-cyclopentenylmethyl) guanine	2000
Alex White Professor Alan Calvert Professor Nicola Curtin Professor Roger Griffin Professor Herbie Newell et al.	Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase	2000
Hannah Barlow Professor Nicola Curtin Professor Alan Calvert Emeritus Professor Bernard Golding Professor Herbie Newell et al.	Resistance-modifying agents. Part 7: 2,6-Disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of α1-acid glycoprotein (AGP)	2000
Daniele Ciceri Antonius Pierik Emeritus Professor Bernard Golding	Stereochemistry of the methyl group in (R)-3-methylitaconate derived by rearrangement of 2-methylideneglutarate catalysed by a coenzyme B12-dependent mutase	2000
Dr Johanne Bentley Dr Christine Arris Professor Alan Calvert Professor Nicola Curtin Professor Jane Endicott et al.	Structure-activity relationships and cellular effects of novel purine- and pyrimidine-based cyclin dependent kinase inhibitors	2000
Emeritus Professor Bernard Golding	Studies on catalytic mechanism of methionine synthase IV. Synthesis of 5-amino-6-(3-butenyl) uracil	2000
Daping Zhang Dr Christine Bleasdale Emeritus Professor Bernard Golding Professor William Watson	Synthesis of enantiopure isoprene epoxides from (s)-lactic acid via 'dispoke' intermediates	2000
Adnan Rafiq Emeritus Professor Bernard Golding	Transalkylation of phosphotriesters using cob(I)alamin: Toward specific determination of DNA-phosphate adducts	2000
Professor Roger Griffin Hannah Barlow Professor Nicola Curtin Professor Alan Calvert Emeritus Professor Bernard Golding et al.	2,6-Disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines as nucleoside transport inhibitors: Structure-activity relationships for binding to alpha(1)-acid glycoprotein (AGP)	1999
Professor Herbie Newell Dr Christine Arris Professor Alan Calvert Professor Nicola Curtin Dr Ashleigh Gibson et al.	Antiproliferative cyclin dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.	1999
Emeritus Professor Bernard Golding	B-12-mediated reactions: A theoretical examination	1999
Emeritus Professor Bernard Golding	Facilitation of enzyme-catalyzed reactions by partial proton transfer: Application to coenzyme-B12-dependent methylmalonyl-CoA mutase	1999
Dr Christine Arris Professor Alan Calvert Professor Nicola Curtin Dr Ashleigh Gibson Emeritus Professor Bernard Golding et al.	In vitro growth activity of novel purine- and pyrimidine-based CDK1 and CDK2 inhibitors.	1999
Peter Smith Hannah Barlow Professor Alan Calvert Professor Nicola Curtin Emeritus Professor Bernard Golding et al.	Novel dipyridamole analogues potentiate the in vitro activity of MTA (LY231514) in the presence of alpha(1)-acid glycoprotein.	1999
Emeritus Professor Bernard Golding	On the Mechanism of Action of Vitamin B12: Theoretical Studies of the 2-Methyleneglutarate Mutase Catalyzed Rearrangement	1999
Emeritus Professor Bernard Golding Professor William Watson	Possible mechanisms of carcinogenesis after exposure to benzene	1999
Professor Nicola Curtin Suzanne Kyle Lan Wang Professor barbara Durkacz Professor Roger Griffin et al.	Potentiation of temozolomide and topotecan growth inhibition by novel potent benzimidazole poly(ADP-ribose) polymerase (PARP) inhibitors	1999
Professor Nicola Curtin Professor Alan Calvert Emeritus Professor Bernard Golding Professor Roger Griffin Professor Herbie Newell et al.	Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α1-acid glycoprotein binding	1999
Dr Christopher Calabrese Huw Thomas Michael Batey Professor Nicola Curtin Professor Roger Griffin et al.	Preclinical pharmacology of novel substituted benzimidazoles - potent inhibitors of poly (ADP-ribose) polymerase	1999
Emeritus Professor Bernard Golding Professor William Clegg Dr Mark Elsegood Professor Roger Griffin	Protecting-group strategies for the synthesis of N4-substituted, and N1,N8-disubstituted spermidines, exemplified by hirudonine	1999
Professor William Clegg Dr Mark Elsegood Professor Roger Griffin Emeritus Professor Bernard Golding	Synthesis of 3-alkoxy- and 3-alkylamino-2-alkyl-3-arylisoindolinones	1999
Emeritus Professor Bernard Golding	Toward a consistent mechanism for diol dehydratase catalyzed reactions: an application of the partial-proton-transfer concept	1999
Emeritus Professor Bernard Golding	Understanding the mechanism of B12-dependent methylmalonyl-CoA mutase: partial proton transfer in action	1999
Professor Alan Calvert Professor Nicola Curtin Emeritus Professor Bernard Golding Professor Roger Griffin Professor Herbie Newell et al.	2-phenylbenzimidazole-4-carboxamides are potent inhibitors of the DNA repair enzyme poly(ADP-ribose)-polymerase (PARP)	1998
Professor Jane Endicott Professor Martin Noble Professor Alan Calvert Professor Nicola Curtin Emeritus Professor Bernard Golding et al.	Insights into CDK inhibitor design from X-ray crystallographic studies	1998
Professor Alan Calvert Professor Nicola Curtin Professor Jane Endicott Emeritus Professor Bernard Golding Professor Roger Griffin et al.	O-6-alkylguanines as selective inhibitors of cyclin dependent kinases	1998
Alex White Emeritus Professor Bernard Golding Professor Roger Griffin Professor Nicola Curtin	Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064	1998
Professor Roger Griffin Professor Alan Calvert Professor Nicola Curtin Professor Herbie Newell Emeritus Professor Bernard Golding et al.	Resistance-modifying agents. 5.1 Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP)	1998
Dr Christine Arris Dr Christine Bleasdale Professor Alan Calvert Professor Nicola Curtin Emeritus Professor Bernard Golding et al.	Mechanism-based inhibition of O-6-methylguanine-DNA methyltransferase.	1996
Professor Roger Griffin Alex White Kenneth Bowman Professor Alan Calvert Professor Nicola Curtin et al.	Novel benzimidazole and quinazolinone inhibitors of the DNA repair enzyme Poly(ADP-ribose)polymerase	1996
Professor Roger Griffin Professor Nicola Curtin Professor Herbie Newell Emeritus Professor Bernard Golding Professor barbara Durkacz et al.	The Role of Inhibitors of Poly(Adp-Ribose) Polymerase as Resistance-Modifying Agents in Cancer-Therapy	1995
Emeritus Professor Bernard Golding Professor Roger Griffin	Discrimination of spermidine amino functions by a new protecting group strategy; application to the synthesis of guanidinylated polyamines, including hirudonine	1994
Dr Christine Arris Dr Christine Bleasdale Professor Alan Calvert Professor Nicola Curtin Emeritus Professor Bernard Golding et al.	Probing the active site and mechanism of action of O-6-methylguanine-DNA methyltransferase with substrate-analogs to (O-6-substituted guanines)	1994
Professor Herbie Newell Dr Ross Maxwell Emeritus Professor Bernard Golding	Invivo and exvivo magnetic resonance spectroscopy as applied to pharmacokinetic studies with anticancer agents: a review	1992