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Lookup NU author(s): Martin Stockley, Professor William Clegg, Emeritus Professor Bernard Golding, Nicola Martin, Dr Laurent Rigoreau, Professor Roger Griffin
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The first reported synthesis of the DNA-PK inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035) is described. The structure of OK-1035 was validated by X-ray crystallography. An IC50 value of 100 muM was determined for inhibition of DNA-PK, and this is approximately 12-fold higher than that reported previously. (C) 2001 Elsevier Science Ltd. All rights reserved.
Author(s): Stockley M, Clegg W, Fontana G, Golding BT, Martin N, Rigoreau LJM, Smith GCM, Griffin RJ
Publication type: Article
Publication status: Published
Journal: Bioorganic & Medicinal Chemistry Letters
Year: 2001
Volume: 11
Issue: 21
Pages: 2837-2841
ISSN (print):
ISSN (electronic): 1464-3405
Publisher: Pergamon
URL: http://dx.doi.org/10.1016/S0960-894X(01)00537-6
DOI: 10.1016/S0960-894X(01)00537-6
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