Publications by Dr Dina Tiniakos - ePrints

Browsing publications by Dr Dina Tiniakos.

Newcastle Authors	Title	Year
Dr Dina Tiniakos Professor Alastair Burt	An End-to-End Platform for Digital Pathology Using Hyperspectral Autofluorescence Microscopy and Deep Learning-Based Virtual Histology	2024
Professor Helen Reeves Dr Dina Tiniakos	British Society of Gastroenterology guidelines for the management of hepatocellular carcinoma in adults	2024
Matt McTeer Dr Dina Tiniakos Professor Cliff Brass Professor Quentin Anstee Professor Paolo Missier et al.	Machine learning approaches to enhance diagnosis and staging of patients with MASLD using routinely available clinical information	2024
Dr Olivier Govaere Dr Megan Hasoon Dr Simon Cockell Dr Dina Tiniakos Professor Ann Daly et al.	A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures	2023
Kristy Wonders Dr Dina Tiniakos Professor Pierre Bedossa Professor Quentin Anstee	Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study	2023
Dr Jack Leslie Dr Jill Hunter Amy Collins Amelia Rushton Lauren Russell et al.	c-Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis	2023
Kristy Wonders Dr Dina Tiniakos Professor Pierre Bedossa Professor Cliff Brass Professor Quentin Anstee et al.	Machine learning algorithm improves detection of NASH (NAS-based) and at-risk NASH: a development and validation study	2023
Dr Brian Ford Dr Shruti Chachra Katrina Rodgers Tabassum Moonira Dr Ziad Al-Oanzi et al.	The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326	2023
Dr Massimo Younes Dr Olivier Govaere Dr Dina Tiniakos Professor Alastair Burt Marco Zaki et al.	Caucasian lean subjects with non-alcoholic fatty liver disease share long-term prognosis of non-lean: time for reappraisal of BMI-driven approach?	2022
Dr Suzanne Madgwick Dr Saimir Luli Helene Sellier Dr Jacqueline Butterworth Dr Jack Leslie et al.	Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential	2022
Dr Steven Masson Dr Dina Tiniakos	Clinical, histological and molecular profiling of different stages of alcohol-related liver disease	2022
Dr Dina Tiniakos Professor Quentin Anstee	Complexity of ballooned hepatocyte feature recognition: Defining a training atlas for artificial intelligence-based imaging in NAFLD	2022
Dr Dina Tiniakos	Consensus Recommendations for Histological Criteria of Autoimmune Hepatitis from the International AIH Pathology Group	2022
Nicola Dyson Dr Nicole Kattner Minna Honkanen-Scott Bethany Hunter Jennifer Doyle et al.	Development and Application of a Semi quantitative Scoring Method for Ultrastructural Assessment of Acute Stress in Pancreatic Islets	2022
Dr Dina Tiniakos	Experimental Intestinal Stenosis Alters Crohn's Disease-Like Intestinal Inflammation in Ileitis-Prone Mice	2022
Dr Dina Tiniakos	How to identify, encourage, and support suitable candidates for leading roles in scientific societies: The UEG experience	2022
Dr Katherine Johnson Dr Peter Leary Dr Olivier Govaere Dr Matthew Barter Sarah Charlton et al.	Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance	2022
Dr Olivier Govaere Dr Rebecca Darlay Dr Julien Peltier Dr Jeremy Palmer Dr Massimo Younes et al.	Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease	2022
Dr Dina Tiniakos	Specific Neuropeptide Expression in Crohn's Disease Ileocolonic Resection Specimens Is Not Associated with Plexitis at the Ileal Margin or Postoperative Recurrence	2022
Dr Marco Zaki Dr Sari Alhasan Dr Ruchi Shukla Misti McCain Maja Laszczewska et al.	Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?	2022
Dr Dina Tiniakos	“Dual aetiology fatty liver disease”: A recently proposed term associated with potential pitfalls	2021
Dr Dina Tiniakos	Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD	2021
Dr Dina Tiniakos	Burnout in gastroenterology: raise awareness and identify drivers	2021
Dr Massimo Younes Rachel Burgoyne Dr Dina Tiniakos Dr Olivier Govaere	Clinical implications of hepatic progenitor cell activation in non-alcoholic fatty liver disease	2021
Dr Dina Tiniakos	Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease	2021
Professor Alastair Burt Professor Pierre Bedossa Dr Dina Tiniakos	Fifty years of impact on liver pathology: a history of the Gnomes	2021
Dr Dina Tiniakos	From the origin of NASH to the future of metabolic fatty liver disease	2021
Dr Dina Tiniakos	Inflammatory myoglandular polyp as a cause of recurrent abdominal pain in a patient with quiescent Crohn's disease	2021
Dr Dina Tiniakos	Keratin 7 expression in hepatic cholestatic diseases	2021
Marco Zaki Dr Ahmed Mahdi Dr Gillian Patman Anna Whitehead Joao Mauricio et al.	Key features of the environment promoting liver cancer in the absence of cirrhosis	2021
Dr Dina Tiniakos	Liver stiffness measurements by 2-dimensional shear wave elastography compared to histological and ultrasound parameters in primary biliary cholangitis	2021
Dr Massimo Younes Dr Olivier Govaere Dr Dina Tiniakos Professor Alastair Burt Marco Youssef William Zaki et al.	Long-term outcomes and predictive ability of non-invasive scoring systems in patients with non-alcoholic fatty liver disease	2021
Dr Arianna Bianchi Dr Letizia Marchetti Dr Hannah Paish Dr Kile Green Dr Dina Tiniakos et al.	Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis	2021
Dr Olivier Govaere Dr Dina Tiniakos Professor Pierre Bedossa Dr Simon Cockell Dr Massimo Younes et al.	NASH limits anti-tumor surveillance in immunotherapy-treated HCC	2021
Dr Dina Tiniakos	Tumor mutation burden testing: a survey of the International Quality Network for Pathology (IQN Path)	2021
Dr Olivier Govaere Dr Dina Tiniakos Professor Quentin Anstee Professor Fiona Oakley	Bone Morphogenic Protein 8B Promotes the Progression of Non-Alcoholic Steatohepatitis	2020
Dr Dina Tiniakos	Burnout among gastroenterologists: How to manage and prevent it	2020
Dr Nicole Kattner Nicola Dyson Dr Yvonne Bury Dr Dina Tiniakos Tracey Davey et al.	Development and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas	2020
Dr Dina Tiniakos	Experimental Models of Partial Intestinal Obstruction in Young Mice: Establishment, and Evaluation	2020
Professor Quentin Anstee Dr Rebecca Darlay Dr Simon Cockell Dr Olivier Govaere Dr Dina Tiniakos et al.	Genome-Wide Association Study of Non-Alcoholic Fatty Liver and Steatohepatitis in a Histologically-Characterised Cohort	2020
Dr Dina Tiniakos	Innervation of the proximal human biliary tree.	2020
Dr Dina Tiniakos	Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?	2020
Dr Massimo Younes Dr Olivier Govaere Dr Dina Tiniakos Professor Alastair Burt Marco Zaki et al.	Presence of Serum Antinuclear Antibodies Does Not Impact Long-Term Outcomes in Nonalcoholic Fatty Liver Disease	2020
Dr Massimo Younes Dr Olivier Govaere Dr Luca Miele Dr Dina Tiniakos Professor Alastair Burt et al.	Presence of Serum Antinuclear Antibodies Does Not Impact Long-Term Outcomes in Nonalcoholic Fatty Liver Disease	2020
Dr Dina Tiniakos Susan Harrison Professor Quentin Anstee	qFIBS: A Novel Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients with Non-Alcoholic Steatohepatitis	2020
Dr Timothy Hardy Kristy Wonders Dr Massimo Younes Professor Pierre Bedossa Entesar Betelmal et al.	The European NAFLD Registry: a real-world longitudinal cohort study of nonalcoholic fatty liver disease	2020
Dr Olivier Govaere Dr Simon Cockell Dr Dina Tiniakos Dr Rachel Queen Dr Massimo Younes et al.	Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis	2020
Dr Dina Tiniakos	Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study	2019
Dr Dina Tiniakos	Bizarre stromal cells in Crohn's disease	2019
Dr Dina Tiniakos	Fibrosis and alcohol-related liver disease	2019
Dr Marie Boyle Kate Hallsworth Dr Dina Tiniakos Professor Quentin Anstee	Health-related Quality of Life in Non-alcoholic Fatty Liver Disease Associates With Hepatic Inflammation.	2019
Dr Sam Tingle Dr Avinash Sewpaul Steven White Dr Dina Tiniakos	Hepatocellular neoplasm of uncertain malignant potential associated with hepatic granulomas featuring p62-positive asteroid bodies.	2019
Dr Maria Perugorria Professor Fiona Oakley Professor Jelena Mann Dr Dina Tiniakos Professor Derek Mann et al.	Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage	2019
Dr Joaquim Majo Dr Dina Tiniakos	Pathology and natural history of organ fibrosis	2019
Dr Marie Boyle Dr Dina Tiniakos Dr Olivier Govaere Dr Massimo Younes Professor Stuart McPherson et al.	Performance of the PRO-C3 collagen neo-epitope biomarker in non-alcoholic fatty liver disease	2019
Dr Sameh Abou-Beih Dr Steven Masson Professor Fiona Oakley Dr Dina Tiniakos	Sinusoidal and pericellular fibrosis in adult post-transplant liver biopsies: association with hepatic stellate cell activation and patient outcome	2019
Dr Dina Tiniakos	Successful treatment of noncirrhotic portal hypertension with eculizumab in paroxysmal nocturnal hemoglobinuria: A case report.	2019
Dr Dave Houghton Dr Kate Hallsworth Dr Sophie Cassidy Christian Thoma Dr Leah Avery et al.	The degree of hepatic steatosis associates with impaired cardiac and autonomic function	2019
Dr Dina Tiniakos Dr Diana Jurk	A novel Sudan Black B-based analogue revives lipofuscin as a biomarker for in vivo senescence	2018
Dr Dina Tiniakos	Can reference images improve interobserver agreement in reporting liver fibrosis?	2018
Dr Dina Tiniakos Professor Quentin Anstee Professor Alastair Burt	Fatty Liver Disease	2018
Dr Dina Tiniakos Joao Pais Maurício-Muir Professor Helen Reeves	Fatty liver disease and hepatocellular carcinoma: The pathologist’s view	2018
Sebastian Mafeld Jeremy French Dr Dina Tiniakos Dr Beate Haugk Professor Derek Manas et al.	Fibrolamellar Hepatocellular Carcinoma: Treatment with Yttrium-90 and Subsequent Surgical Resection	2018
Dr Olivier Govaere Dr Dina Tiniakos	Hepatic Progenitor Cells in Metastatic Liver Carcinomas	2018
Dr Scott Anderson Dr Michael White Sarah Armour Rashmi Maheshwari Dr Dina Tiniakos et al.	Loss of end-differentiated β-cell phenotype following pancreatic islet transplantation	2018
Dr Jess Dyson Dr Dina Tiniakos Professor David Jones	The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines	2018
Dr Dina Tiniakos	A case of ruptured HCC in resolving NASH associated with type 2 diabetes: Is early detection of diabetes-related HCC feasible?	2017
Professor Stuart McPherson Dr Nina Wilson Dr Dina Tiniakos Dr Jennifer Wilkinson Professor Alastair Burt et al.	A randomised controlled trial of losartan as an anti-fibrotic agent in non-alcoholic steatohepatitis	2017
Professor Stuart McPherson Dr Timothy Hardy Dr Dina Tiniakos Professor Alastair Burt Professor Chris Day et al.	Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis	2017
Dr Mikolaj Ogrodnik Dr Satomi Miwa Dr Dina Tiniakos Dr Caroline Wilson Professor Chris Day et al.	Cellular senescence drives age-dependent hepatic steatosis	2017
Dr Dave Houghton Christian Thoma Dr Kate Hallsworth Dr Sophie Cassidy Dr Timothy Hardy et al.	Exercise Reduces Liver Lipids and Visceral Adiposity in Patients With Nonalcoholic Steatohepatitis in a Randomized Controlled Trial	2017
Professor Alastair Burt Dr Dina Tiniakos	Fibrosis evaluation by transient elastography in alcoholic liver disease: Is the histological scoring system impacting cutoff values?	2017
Dr Timothy Hardy Dr Mujdat Zeybel Professor Chris Day Dr Christian Dipper Dr Steven Masson et al.	Plasma DNA methylation: A potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease	2017
Dr Anna Moles Fernandez Dr Jacqueline Butterworth Dr Jill Hunter Dr Jack Leslie Helene Sellier et al.	A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-kB dependent liver regeneration and cancer	2016
Dr Dina Tiniakos	Atrophic hepatocytes express keratin 7 in ischemia-associated liver lesions	2016
Dr Dina Tiniakos Professor Quentin Anstee Professor Chris Day Professor Alastair Burt Dr John Brain et al.	Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference	2016
Kile Green Dr Laura Jopson Dr Ben Barron-Millar Barbara Innes Sarah Pagan et al.	Early Molecular Stratification of High-risk Primary Biliary Cholangitis	2016
Dr Sameh Abou-Beih Dr Steven Masson Professor Fiona Oakley Dr Dina Tiniakos	Evaluation of centrilobular fibrosis in post-transplant liver: Preliminary results	2016
Dr Dina Tiniakos	Evaluation of liver fibrosis: “Something old, something new…”	2016
Dr Jess Dyson Dr Dina Tiniakos Professor Stuart McPherson	Liver toxicity associated with sofosbuvir, an NS5A inhibitor and ribavirin use	2016
Dr Sari Alhasan Dr Beate Haugk Laura Ogle Dr Gary Beale Anna Long et al.	Sulfatase-2: a prognostic biomarker and candidate therapeutic target in patients with pancreatic ductal adenocarcinoma	2016
Dr Dina Tiniakos	Alcoholic and Non-alcoholic Fatty Liver Disease	2015
Dr Dina Tiniakos	Associations between dietary intake and the presence of the metabolic syndrome in patients with non-alcoholic fatty liver disease	2015
Dr Dina Tiniakos	Blood redox status is associated with the likelihood of nonalcoholic fatty liver disease irrespectively of diet's total antioxidant capacity	2015
Professor Alastair Burt Dr Dina Tiniakos	Diagnosis and Assessment of NAFLD: Definitions and Histopathological Classification	2015
Anna Whitehead Dr Gillian Patman Professor Chris Day Dr Dina Tiniakos Professor Quentin Anstee et al.	Effects of FXR agonist PX20606 on tumour formation in animal models of non-alcoholic fatty liver disease	2015
Dr Dina Tiniakos	Estrogen receptors β1 and β2 are associated with distinct responses of estrogen receptor α-positive breast carcinoma to adjuvant endocrine therapy.	2015
Dr Dina Tiniakos	Histamine H₃ and H₄ Receptor Ligands Modify Vascular Histamine Levels in Normal and Arthritic Large Blood Vessels In Vivo	2015
Dr Dina Tiniakos	Increased abdominal fat levels measured by bioelectrical impedance are associated with histological lesions of nonalcoholic steatohepatitis.	2015
Dr Dina Tiniakos	Keratin 19 protein expression is an independent predictor of survival in human hepatocellular carcinoma	2015
Dr Dina Tiniakos	Liver innervation and hepatic function: new insights	2015
Dr Caroline Wilson Dr Diana Jurk Nicola Fullard Paul Banks Dr Agata Page et al.	NFkB1 is a suppressor of neutrophil-driven hepatocellular carcinoma	2015
Dr Dina Tiniakos Dr Yvonne Bury	p62 (SQSTM1) expression in human liver disease: Preliminary results	2015
Anna Whitehead Laura Ogle Dr Gillian Patman Dr Ali Anwar Dr Dina Tiniakos et al.	Ras and p-ERK in metabolic syndrome associated Hepatocellular Carcinoma (HCC)	2015
Dr Dina Tiniakos Dr John Brain Dr Yvonne Bury	Role of Histopathology in Autoimmune Hepatitis	2015
Dr Anna Moles Fernandez Dr Jacqueline Butterworth Dr Jill Hunter Dr Dina Tiniakos Professor Derek Mann et al.	Thr505 RelA phosphorylation controls liver proliferative response and supresses NF-kappa B tumor-promoting activities	2015
Dr Caroline Wilson Dr Lindsay Murphy Jack Leslie Dr Stuart Kendrick Jeremy French et al.	Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease	2015
Professor Alastair Burt Dr Dina Tiniakos	Well-differentiated hepatocellular neoplasm of uncertain malignant potential - reply	2015
Dr Dina Tiniakos	Adherence to the Mediterranean diet is associated with the severity of non-alcoholic fatty liver disease	2014
Dr Dina Tiniakos	CD138 (syndecan 1) expression in health and disease	2014
Dr Dina Tiniakos	Dental Pulp cells enhance bone healing in a rat osteotomy model	2014
Dr Dina Tiniakos	Estrogen receptor beta 2 is inversely correlated with Ki-67 in hyperplastic and noninvasive neoplastic breast lesions	2014
Dr Dina Tiniakos	Histological features of chronic hepatitis C in haemodialysis patients	2014
Dr Dina Tiniakos	Liver Function Breath Tests for Differentiation of Steatohepatitis from Simple Fatty Liver in Patients with Nonalcoholic Fatty Liver Disease	2014
Dr Dina Tiniakos	Liver regeneration: immunohistochemichal study of intrinsic hepatic innervation after partial hepatectomy in rats	2014
Dr Dina Tiniakos	Medial tibial stress syndrome: A skeleton from medieval Rhodes demonstrates the appearance of the bone surface	2014
Dr Yvonne Bury Naomi Brown Dr Dina Tiniakos	p53 expression in human hepatocellular carcinoma (HCC): correlation with dysadherin expression and patient prognosis	2014
Dr Dina Tiniakos Professor Alastair Burt	Pathology of the Liver Sinusoids	2014
Dr Dina Tiniakos	The impact of cereal grain consumption on the development and severity of non-alcoholic fatty liver disease	2014
Dr Dina Tiniakos Professor Alastair Burt	The liver, gallbladder and pancreas	2014
Dr Yang-Lin Liu Professor Helen Reeves Professor Alastair Burt Dr Dina Tiniakos Professor Stuart McPherson et al.	TM6SF2 rs58542926 Influences Hepatic Fibrosis Progression in Patients with Non-Alcoholic Fatty Liver Disease	2014
Professor Pierre Bedossa Professor Alastair Burt Dr Dina Tiniakos Dr John Brain Dr Yvonne Bury et al.	Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease	2014
Dr Dina Tiniakos Dr John Brain Dr Yvonne Bury	Utility and appropriateness of the FLIP algorithm and SAF score in the evaluation of biopsies of nonalcoholic fatty liver disease.	2014
Professor Pierre Bedossa Professor Alastair Burt Dr Dina Tiniakos	Well differentiated hepatocellular neoplasm of uncertain malignant potential: Proposal for a new diagnostic category	2014
Dr Dina Tiniakos	Application, Utility and Validation of a New Histological System for Classification of NAFLD in Patients with Metabolic Syndrome	2013
Dr Dina Tiniakos	E2F transcription factors and digestive system malignancies: How much do we know?	2013
Dr Dina Tiniakos	Estrogen receptor beta 2 is associated with poor prognosis in estrogen receptor alpha-negative breast carcinoma	2013
Dr Dina Tiniakos	Increased Density of Cutaneous Nerve Fibres in the Affected Dermatomes After Herpes Zoster Therapy	2013
Dr Dina Tiniakos	The Severity of Histologic Liver Lesions Is Independent of Body Mass Index in Patients With Nonalcoholic Fatty Liver Disease	2013
Dr Dina Tiniakos	E2F-1 is overexpressed and pro-apoptotic in human hepatocellular carcinoma	2012
Dr Dina Tiniakos	Significance of liver histology in HBsAg-positive, IgM anti-HBc-negative acute hepatitis B virus-related hepatitis	2012
Dr Dina Tiniakos	Treatment With Simvastatin Inhibits the Formation of Abdominal Aortic Aneurysms in Rabbits	2012
Dr Dina Tiniakos	Effect of Antiviral Therapy on the Immunohistochemical Expression of bcl-xL and Bax Protein in Patients With HBeAg-Negative Chronic Hepatitis B	2011
Dr Dina Tiniakos	Exercise for NAFLD: Does Intensity Matter?	2011
Dr Dina Tiniakos	Fighting the bushfire in HCC trials	2011
Dr Dina Tiniakos	Hepatitis B surface antigen: Relation to hepatitis B replication parameters in HBeAg-negative chronic hepatitis B	2011
Dr Dina Tiniakos	IGF-I ameliorates hippocampal neurodegeneration and protects against cognitive deficits in an animal model of temporal lobe epilepsy	2011
Dr Dina Tiniakos	Inflammation in nonalcoholic steatohepatitis	2011
Dr Dina Tiniakos	Insights into ectopic estrogen receptor expression, nucleocytoplasmic distribution and interaction with chromatin obtained with new antibodies to estrogen receptors α and β	2011
Dr Dina Tiniakos	Multiplexed analysis of angiogenesis and lymphangiogenesis factors predicts outcome for non-small cell lung cancer patients	2011
Dr Dina Tiniakos	Serum leptin and ghrelin in chronic hepatitis C patients with steatosis	2011
Dr Dina Tiniakos	Dysadherin expression in human hepatocellular carcinoma: preliminary results	2010
Dr Dina Tiniakos	Histopathology of nonalcoholic fatty liver disease	2010
Dr Dina Tiniakos	Primary Hepatic Actinomycosis	2010
Dr Dina Tiniakos	Thrombotic risk factors and liver histologic lesions in non-alcoholic fatty liver disease	2009
Dr Dina Tiniakos	KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program	2008
Dr Dina Tiniakos Professor Alastair Burt	Ontogeny of human intrahepatic innervation	2008
Dr Dina Tiniakos	Serum apoptotic caspase activity as a marker of severity in HBeAg-negative chronic hepatitis B virus infection	2008
Dr Dina Tiniakos Dr John Anderson	c-fos oncogene expression in human breast carcinoma	2000
Dr Dina Tiniakos Dr John Anderson	Production and characterization of monoclonal antibodies to the human c-fos oncoprotein effective an routinely-processed tissues	2000
Dr Dina Tiniakos Dr John Anderson Dr Mary Robinson Professor David Neal	c-jun oncogene expression in transitional cell carcinoma of the urinary bladder	1994