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Lookup NU author(s): Dr Dina Tiniakos
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
AIM:To investigate atrophic parenchymal changes in ischemic liver conditions.DESIGN:We studied 18 cases of hepatic lesions with atrophic changes due to altered blood flow (hepatic venous congestion n=15 including 4 cases with additional nodular regenerative hyperplasia-NRH, NRH n=1, and antiphospholipid syndrome with patchy parenchymal atrophy n=2). Metaplastic hepatocellular changes, hepatocyte proliferation, hepatic stellate cell (HSC) activation, and sinusoidal capillarization were examined immunohistochemically with antibodies to keratins (K) 7 and 19, Ki67, αSMA and CD34, respectively.RESULTS:K7 was positive and K19 was negative in zone 3 atrophic hepatocytes in venous congestion and in areas of plate atrophy, as well as in congested or compressed sites in NRH. Sinusoidal CD34-positivity indicating capillarization accompanied K7 immunoexpression. Masson trichrome revealed sinusoidal fibrosis to be restricted in atrophic areas, usually mild and in 7 cases focally dense. αSMA expression expanded beyond K7-positive areas. Ki67 was negative in K7-positive hepatocytes.CONCLUSION:Ischemic parenchymal changes are characterized by hepatocyte K7 immunoexpression, sinusoidal capillarization, HSC activation and lack of cellular proliferation, indicating an early reaction of the major liver parenchyma cellular components creating a more resistant microenvironment. These phenotypic alterations may prove valuable in the discrimination of ischemic liver lesions.
Author(s): Delladetsima I, Sakellariou S, Kokkori A, Tiniakos D
Publication type: Article
Publication status: Published
Journal: Histology Histopathology
Year: 2016
Volume: 31
Issue: 10
Pages: 1089-1094
Print publication date: 01/10/2016
Online publication date: 20/07/2016
Acceptance date: 18/02/2016
Date deposited: 25/02/2016
ISSN (print): 0213-3911
ISSN (electronic): 1699-5848
Publisher: Universidad de Murcia
URL: http://dx.doi.org/10.14670/HH-11-738
DOI: 10.14670/HH-11-738
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