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Estrogen receptor beta 2 is inversely correlated with Ki-67 in hyperplastic and noninvasive neoplastic breast lesions

Lookup NU author(s): Dr Dina Tiniakos

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Abstract

The purpose of the study is to compare expression levels of I center dot R alpha, ER beta 1, ER beta 2 and cell proliferation marker Ki-67 in normal breast and hyperplastic and noninvasive neoplastic breast lesions.Routinely processed breast tissue from 55 patients provided 65 cases of noninvasive lesions, namely, epithelial hyperplasia of usual type (HUT), apocrine metaplasia (AM), atypical hyperplasia (AH) and ductal carcinoma in situ (DCIS) and 14 cases of adjacent normal breast tissue. Expression of ER alpha, ER beta 1 and ER beta 2 were evaluated using immunohistochemistry and correlated with Ki-67 labeling index (Ki-67 LI) and menopausal status of the patients.Compared with normal breast, ER alpha expression increased in low to intermediate-grade DCIS (DCIS1/2) and tended to decrease in high-grade DCIS, while ER beta 1 expression decreased in DCIS irrespective of grade. Mean Ki-67 LI in HUT, low to intermediate-grade DCIS and high-grade DCIS was higher than in normal breast. Higher than normal Ki-67 LI correlated with low ER beta 2 expression in the whole set of cases and with high ER alpha expression and low ER beta 2 expression in the postmenopausal cases of the subset that is generated by excluding AM and high-grade DCIS. Postmenopausal status correlated with low ER beta 1 expression in the whole set and with higher than normal Ki-67 LI, high ER alpha expression and low ER beta 1 expression in the subset.These findings are in accordance with an ER alpha-opposing oncosuppressive role of ER beta 2 in mammary carcinogenesis along the HUT-AH-DCIS1/2 pathway.

Publication metadata

Author(s): Chantzi NI, Palaiologou M, Stylianidou A, Goutas N, Vassilaros S, Kourea HP, Dhimolea E, Mitsiou DJ, Tiniakos DG, Alexis IN

Publication type: Article

Publication status: Published

Journal: Journal of Cancer Research and Clinical Oncology

Year: 2014

Volume: 140

Issue: 6

Pages: 1057-1066

Print publication date: 01/06/2014

Online publication date: 27/03/2014

Acceptance date: 15/03/2014

ISSN (print): 0171-5216

ISSN (electronic): 1432-1335

Publisher: Springer

URL: http://dx.doi.org/10.1007/s00432-014-1652-0

DOI: 10.1007/s00432-014-1652-0

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