Publications by Dr John Mansfield - ePrints

Browsing publications by Dr John Mansfield.

Newcastle Authors	Title	Year
Dr Nicola Wyatt Dr Hannah Watson Dr Dean Allerton Michelle Bardgett Dr Emma Clark et al.	Defining predictors of responsiveness to advanced therapies in Crohn’s disease and ulcerative colitis: Protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine	2024
Dr John Mansfield Professor Chris Lamb	Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease	2023
Dr John Mansfield	Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis	2023
Professor Chris Lamb Dr John Mansfield	Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility	2022
Professor Chris Lamb Dr John Mansfield	Oral ferric maltol does not adversely affect the intestinal microbiome of patients or mice, but ferrous sulphate does	2021
Dr Meghan Acres Dr Gill Hulme Dr Christopher Carey Dr John Mansfield Emeritus Professor John Kirby et al.	Regulation and role of αE integrin and gut homing integrins in migration and retention of intestinal lymphocytes during inflammatory bowel disease	2021
Dr John Mansfield	HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease	2020
Dr John Mansfield	Association of Genetic Variants in NUDT15 with Thiopurine-Induced Myelosuppression in Patients with Inflammatory Bowel Disease	2019
Emeritus Professor Nicol Ferrier Professor John Isaacs Dr John Mansfield Professor Allan Young	Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data	2019
Professor Chris Lamb Dr John Mansfield Emeritus Professor John Kirby	The Importance of Molecular Immune Investigation in Therapeutic Clinical Development for Biomarker Assessment	2019
Professor Chris Lamb Dr John Mansfield	NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease	2018
Professor Chris Lamb Anna Long Dr John Mansfield Emeritus Professor John Kirby	AlphaE Integrin Expression Is Increased in the Ileum Relative to the Colon and Unaffected by Inflammation	2018
Dr John Mansfield	Can faecal calprotectin predict relapse in inflammatory bowel disease: A mini review	2018
Dr John Mansfield	Exome sequencing and genotyping identify a rare variant in NLRP7 gene associated with ulcerative colitis	2018
Dr John Mansfield	IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes	2018
Professor Chris Lamb Dr John Mansfield	The Impact of NOD2 Variants on Fecal Microbiota in Crohn's Disease and Controls Without Gastrointestinal Disease	2018
Professor Chris Lamb Dr John Mansfield Anna Long Maria Price Dr Graeme O'Boyle et al.	aEß7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis	2017
Dr Ally Speight Dr John Mansfield	Editorial: how effective is vedolizumab in the 'real world'?	2017
Professor Chris Lamb Dr John Mansfield	Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7	2017
Dr John Mansfield	Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease	2017
Professor Chris Lamb Dr John Mansfield	Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease	2017
Dr John Mansfield	A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies	2016
Professor Chris Lamb Dr John Mansfield	A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis	2016
Professor Chris Lamb Dr John Mansfield Emeritus Professor John Kirby	Association Between Response to Etrolizumab and Expression of Integrin alpha E and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis	2016
Dr John Mansfield	Clinical Features and HLA Association of 5-Aminosalicylate (5-ASA)-induced Nephrotoxicity in Inflammatory Bowel Disease	2016
Dr John Mansfield	Genetic Association Analysis Reveals Differences in the Contribution of NOD2 Variants to the Clinical Phenotypes of Orofacial Granulomatosis	2016
Dr John Mansfield	Infliximab versus ciclosporin for steroid-resistant acute severe ulcerative colitis (CONSTRUCT): a mixed methods, open-label, pragmatic randomised trial	2016
Dr John Mansfield	Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: A genetic association study	2016
Dr Richard Speight Tracey Davey Dr Kathryn White Emeritus Professor John Kirby Dr John Mansfield et al.	Activation of the bile acid receptor, farnesoid-x receptor, maintains gut epithelial cell morphology, possibly via inhibition of myosin light chain kinase expression	2015
Dr Richard Speight Anna Whitehead Dr Gillian Patman Dr John Mansfield Professor Helen Reeves et al.	Activation of the bile acid receptor, Farnesoid-X Receptor, may reduce Ileal Inflammatory Cytokine expression in an animal model of diet-induced obesity	2015
Professor Chris Lamb Dr John Mansfield Jennifer Kirby	AlphaE (alpha E) integrin protein and gene expression are augmented in the ileum relative to the colon in Crohn's disease	2015
Dr John Mansfield	High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis	2015
Dr John Mansfield	Pooled Sequencing of 531 Genes in Inflammatory Bowel Disease Identifies an Associated Rare Variant in BTNL2 and Implicates Other Immune Related Genes	2015
Professor Chris Lamb Dr John Mansfield	Predicting inflammatory pathology at capsule enteroscopy: what is the utility of a raised faecal calprotectin?	2015
Dr John Mansfield	HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants	2014
Dr Michael Keir Dr John Mansfield Professor Chris Lamb Emeritus Professor John Kirby	AlphaE integrin expression as a predictive biomarker for induction of clinical remission by etrolizumab: Analysis of a phase II trial in moderate-to-severely active ulcerative colitis	2014
Dr John Mansfield Professor Chris Lamb Emeritus Professor John Kirby	Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial	2014
Professor Chris Lamb Maria Price Dr John Mansfield	Faecal Calprotectin Is Useful In Predicting Long Term Disease Recurrence In Post-operative Crohn’s	2014
Professor Chris Lamb Dr John Mansfield	The Impact Of NOD2 Variants on Gut Microbiota in Crohn’s Disease and Healthy Controls	2014
Dr Carl Gamble Professor Chris Lamb Dr John Mansfield	Thiopurine withdrawal during sustained clinical remission in inflammatory bowel disease: relapse and recapture rates, with predictive factors in 237 patients	2014
Professor Chris Lamb Dr John Mansfield Dr Graeme O'Boyle Professor David Jones Jennifer Kirby et al.	Ulcerative colitis: The alpha E beta 7 integrin is associated with a high frequency of Th17, Th1 and Th17/Th1 CD4 lymphocytes	2014
Professor Chris Lamb Dr John Mansfield Dr Graeme O'Boyle Professor David Jones Dr Michael Keir et al.	Ulcerative Colitis: The Alpha-e-beta-7 Integrin Is Associated With A High Frequency Of Th17, Th1 And Th17/th1 Cd4 Lymphocytes	2014
Dr Leslie Mitchell Dr John Mansfield Dr Janet McLelland Dr Stephanie Needham	Vulval oedema: how many doctors does it take to make a diagnosis?	2014
Dr John Mansfield	A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis	2013
Professor Chris Lamb Dr Lily Lamb Dr John Mansfield	Sexually transmitted infections manifesting as proctitis	2013
Professor Chris Lamb Dr Graeme O'Boyle Professor David Jones Dr John Mansfield Emeritus Professor John Kirby et al.	Blockade of the B7 integrin prevents adherence of t lymphocytes to MAdCAM-1 in an in vitro model of vascular microcirculation post-capillary shear flow	2012
Dr John Mansfield	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease	2012
Dr Catherine Stroud Professor Matthew Collin Professor Graham Jackson Dr Terence Flood Dr John Mansfield et al.	Idiopathic colitis following haematopoietic stem cell transplantation for chronic granulomatous disease: Three cases at a national centre	2012
Professor Chris Lamb Maria Price Dr John Mansfield	A real life retrospective analysis of drug expenditure reveals no significant cost difference between infliximab and adalimumab in the treatment of Adult Crohn's Disease	2011
Professor Chris Lamb Dr John Mansfield	Measurement of faecal calprotectin and lactoferrin in inflammatory bowel disease	2011
Dr John Mansfield	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47	2011
Professor Chris Lamb Maria Price Professor David Jones Dr John Mansfield	Patients with Crohn's Disease report high levels of fatigue during a symptomatic disease flare	2011
Dr John Mansfield	Screening for rare pathogenic sequence variants in inflammatory bowel disease	2011
Dr Catherine Stroud Dr John Mansfield Dr Terence Flood Dr Gavin Spickett	Diagnostic dilemma	2010
Emeritus Professor Nicol Ferrier Professor John Isaacs Dr John Mansfield Professor Mark Walker	Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls	2010
Dr John Mansfield	Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci	2010
Dr John Mansfield	Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease	2010
Dr John Mansfield	Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease	2010
Dr Sohom Maitra Professor Chris Lamb Dr Andrew McLean-Tooke Dr Gavin Spickett Dr John Mansfield et al.	Anti-tissue transglutaminase antibodies in the follow-up of adult coeliac disease	2009
Professor Chris Lamb Mohamed Mohiuddin Fintan Bergin Dr Jonathan Hanson Dr John Mansfield et al.	Faecal calprotectin or lactoferrin can identify postoperative recurrence in Crohn's disease	2009
Lynsey Cotterill Dr John Mansfield	Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region	2009
Dr John Mansfield	Investigation of Crohn's Disease Risk Loci in Ulcerative Colitis Further Defines Their Molecular Relationship	2009
Professor Chris Lamb Mohamed Mohiuddin Fintan Bergin Dr Jonathan Hanson Dr John Mansfield et al.	Longitudinal Study of Faecal Markers Following Ileal Resection in Crohn's Disease: Do Calprotectin and Lactoferrin Normalise Post Operatively?	2009
Mohamed Mohiuddin Professor Chris Lamb Fintan Bergin Dr Jonathan Hanson Dr John Mansfield et al.	Post Operative Crohn's Disease: The Role of Faecal Calprotectin and Lactoferrin in Assessing Disease Recurrence Following Ileal Resection	2009
Dr John Mansfield	Safety of bisphosphonates in women of child bearing age	2009
Dr John Mansfield	Searching for Genotype-Phenotype Structure: Using Hierarchical Log-Linear Models in Crohn Disease	2009
Dr John Mansfield	Association of a promoter variant and copy number polymorphisms at the IRGM locus with Crohn's disease	2008
Dr John Mansfield	Copy Number Variation at the Crohn's disease susceptibility locus, IRGM	2008
Dr John Mansfield	Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease	2008
Dr John Mansfield	Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease	2008
Dr Catherine Todhunter Dr John Mansfield	A non-synonymous SNP in an autophagy-related gene is associated with Crohn's disease	2007
Dr John Mansfield	A Nonsynonymous SNP in ATG16L1 Predisposes to Ileal Crohn's Disease and Is Independent of CARD15 and IBD5	2007
Dr John Mansfield	A randomized, double-blind, placebo-controlled trial of lenalidomide in the treatment of moderately severe active Crohn's disease	2007
Dr Sohom Maitra Dr Gavin Spickett Dr John Mansfield	Anti-tissue transglutaminase antibody quantification is useful in the follow-up of coeliac disease patients	2007
Dr Catherine Todhunter Dr Peter Donaldson Dr John Mansfield	Combined Evidence From Three Large British Association Studies Rejects TUCAN/CARD8 as an IBD Susceptibility Gene	2007
Professor Allan Young Emeritus Professor Nicol Ferrier Mohamed Mohiuddin Dr Catherine Todhunter Dr John Mansfield et al.	Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls	2007
Dr John Mansfield	IL23R Variation Determines Susceptibility But Not Disease Phenotype in Inflammatory Bowel Disease	2007
Dr Catherine Todhunter Dr John Mansfield	In situ hybridisation for human defensins, lysozyme, spla2 and TNF alpha in Crohn's disease and controls	2007
Dr John Mansfield	Investigation of assocaiation of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population	2007
Dr John Mansfield	Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population	2007
Dr John Mansfield	Reply	2007
Dr Catherine Todhunter Dr John Mansfield	Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility	2007
Dr Catherine Todhunter Dr John Mansfield	5Q31 haplotype and relapse after small bowel resection	2006
Dr Katrina Robinson Dr John Mansfield	Audit of inflammatory bowel disease clinics: Results from two patient satisfaction surveys	2006
Dr John Mansfield	Direct or indirect association in a complex disease: The role of SLC22A4 and SLC22A5 functional variants in Crohn disease	2006
Dr Catherine Todhunter Lyn Wilkinson Alison Burt Dr John Mansfield	Histological phenotype of CARD15 genotype	2006
Dr John Mansfield	Mutation, selection, and evolution of the Crohn disease susceptibility gene CARD15	2006
Dr Nicholas Thompson Dr John Mansfield	Adenocarcinoma as a complication of small bowel Crohn's disease	2005
Dr John Mansfield	Association of DLG5 R30Q variant with inflammatory bowel disease	2005
Dr Catherine Todhunter Maria Price Alison Sutherland-Craggs Dr Peter Donaldson William Cunliffe et al.	CARD 15, smoking, and time to second operation in ileal Crohn's disease	2005
Dr John Mansfield	How Good is Zoom Endoscopy in Assessing Villous Atrophy in Coeliac Disease?	2005
Dr Steven Masson Dr John Mansfield	How important is onset of action in ulcerative colitis therapy?	2005
Dr Catherine Todhunter Dr Alison Sutherland Dr Peter Donaldson Professor Ann Daly Emeritus Professor Roger Francis et al.	Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn's disease	2005
Dr John Mansfield	Multiple SNPs at the IBD5 locus contribute to the risk of Crohn's disease	2005
Dr John Mansfield	Review article: smoking cessation as primary therapy to modify the course of Crohn's disease	2005
Dr John Mansfield	Yersinia enterocolitica infection in a patient with hemachromatosis masquerading as proximal colon cancer with liver metastases: Report of a case	2005
Dr John Mansfield	Fine mapping of the 5q31 risk haplotype in Crohn's disease	2004
John Wayman Dr John Mansfield Dr Kenneth Matthewson Dr David Richardson Professor Michael Griffin et al.	Combined percutaneous and endoscopic procedures for bile duct obstruction: Simultaneous and delayed techniques compared	2003
Dr John Mansfield Dr Peter Donaldson	Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease	2003
Dr John Mansfield Dr Peter Donaldson	Genetic evidence for interaction of the 5Q31 cytokine locus and the CARD15 gene in Crohn's disease	2003
Dr John Mansfield	Genetic variation at the chromosome 16 chemokine gene cluster: Development of a strategy for association studies in complex disease	2003
Dr Alison Sutherland Dr John Mansfield	Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease	2003
Dr John Mansfield	Management of irritable bowel syndrome	2003
Alison Sutherland-Craggs Dr John Mansfield Dr Peter Donaldson Professor Ann Daly Dr Nicholas Thompson et al.	Osteoporosis in Crohn's disease is not determined by vitamin D receptor and interleukin-6 genotype	2003
Dr John Mansfield	Pentasa may not be the optimal 5ASA	2003
Dr Ahmed Jaafar Dr John Mansfield Dr Nicholas Thompson	Screening for malnutrition: Impact of the malnutrition universal screening tool (MUST)	2003
Dr John Mansfield	Sequence variation in the CARD15 (nod2) gene and susceptibility to Crohn's disease	2003
Dr John Mansfield	Which 5-ASA?	2003
Dr John Mansfield	A double-blind comparison of balsalazide, 6.75 g daily, and sulfasalazine, 3 g daily, in patients with newly diagnosed or relapsed active ulcerative colitis	2002
Dr John Mansfield	A double-blind comparison of balsalazide, 6.75 g, and sulfasalazine, 3 g, as sole therapy in the management of ulcerative colitis	2002
Dr John Mansfield	Contribution of genetic variants at CARD15 and the chromosome 5q31 locus to Crohn's disease	2002
Alison Sutherland-Craggs Dr John Mansfield Dr Mark Hudson Professor Ann Daly Emeritus Professor Roger Francis et al.	Osteoporosis in Crohn's disease is not determined by NOD2 genotype [abstract]	2002
Dr John Mansfield	Smoking cessation in Crohn's disease: Worthwhile results are possible [abstract]	2002
Dr John Mansfield	The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease	2002
Dr Ann Curtis Dr Mark Welfare Dr Mark Hudson Dr Peter Donaldson Dr John Mansfield et al.	Absence of a genetic association between IL-1RN and IL-1B gene polymorphisms in ulcerative colitis and crohn disease in multiple populations from northeast England	2001
Dr Peter Donaldson Dr Mark Welfare Dr Nicholas Thompson Dr John Mansfield	Genetic association studies in IBD; Negative results from three candidate genes	2001
Dr John Mansfield	Review article: The risk of lymphoma associated with inflammatory bowel disease and immunosuppressive treatment	2001
Dr Alison Sutherland Professor Chris Day Dr Mark Welfare Professor Ann Daly Dr John Mansfield et al.	Role of polymorphisms in the interleukin-10 gene in determining disease susceptibility and phenotype in inflamatory bowel disease	2001
Dr Alison Sutherland Dr Mark Welfare Dr Peter Donaldson Dr John Mansfield	The CC chemokine receptor 5 Delta 32 mutation is not associated with inflammatory bowel disease (IBD) in NE England	2001
Dr Dale Huey Dr John Mansfield Dr Stefan Plusa	Psychological factors which influence adjustment to inflammatory bowel disease	2000
Dr David Nylander Dr Michael Bramble Dr John Mansfield	Recurrent Crohn's disease after surgery is dependent on timing of surgery and smoking, but not on use of 5ASA drugs	1999
Dr John Mansfield Richard Charnley	Practice in endoscopic cholangiopancreatography in Denmark differs from that in Britain	1996