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Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

Lookup NU author(s): Dr John Mansfield

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Abstract

We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases. © 2008 Nature Publishing Group.


Publication metadata

Author(s): Fisher SA, Tremelling M, Anderson CA, Gwilliam R, Bumpstead S, Prescott NJ, Nimmo ER, Massey D, Berzuini C, Johnson C, Barrett JC, Cummings FR, Drummond H, Lees CW, Onnie CM, Hanson CE, Blaszczyk K, Inouye M, Ewels P, Ravindrarajah R, Keniry A, Hunt S, Carter M, Watkins N, Ouwehand W, Lewis CM, Cardon L, Lobo A, Forbes A, Sanderson J, Jewell DP, Mansfield JC, Deloukas P, Mathew CG, Parkes M, Satsangi J

Publication type: Article

Publication status: Published

Journal: Nature Genetics

Year: 2008

Volume: 40

Issue: 6

Pages: 710-712

Print publication date: 01/06/2008

ISSN (print): 1061-4036

ISSN (electronic): 1546-1718

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ng.145

DOI: 10.1038/ng.145

PubMed id: 18438406


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Funding

Funder referenceFunder name
Medical Research Council
Wellcome Trust
089120Wellcome Trust
090532Wellcome Trust
076113Wellcome Trust
077011Wellcome Trust
CZB/4/540Chief Scientist Office
G0000934Medical Research Council
G0400874Medical Research Council
G0600329Medical Research Council
G0800383Medical Research Council
G0802320Medical Research Council
G0800759Medical Research Council
MC_U105260799Medical Research Council
MC_QA137934Medical Research Council

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