Publications by Professor Rakesh Heer - ePrints

Browsing publications by Professor Rakesh Heer.

Newcastle Authors	Title	Year
Rebecca Garnham Dr Daniel Geh Ryan Nelson Erik Ramon Gil Laura Wilson et al.	ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3Gal1) synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer	2024
Adriana Buskin Dr Emma Scott Ryan Nelson Dr Luke Gaughan Professor Craig Robson et al.	Engineering prostate cancer in vitro: what does it take?	2023
Dr Ge Yu Stephen Rice Professor Rakesh Heer Dr Emma Clark Professor Luke Vale et al.	Photodynamic Diagnosis-guided Transurethral Resection of Bladder Tumour in Participants with a First Suspected Diagnosis of Intermediate- or High-risk Non–muscle-invasive Bladder Cancer: Cost-effectiveness Analysis Alongside a Randomised Controlled Trial	2023
Rebecca Garnham Dr Daniel Geh Ryan Nelson Erik Ramon Gil Laura Wilson et al.	ST3Gal1 synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer	2023
Dr Emma Scott Emily Archer Goode Rebecca Garnham Dr Kirsty Hodgson Maggie Orozco Moreno et al.	ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression	2023
Dr Kirsty Hodgson Maggie Orozco Moreno Dr Emma Scott Rebecca Garnham Karen Livermore et al.	The role of GCNT1 mediated O-glycosylation in aggressive prostate cancer	2023
Dr Emma Scott Dr Kirsty Hodgson Kat Cheung Edward Yo Laura Wilson et al.	Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth	2023
Professor Rakesh Heer Dr Ge Yu	A Randomized Trial of PHOTOdynamic Surgery in Non–Muscle-Invasive Bladder Cancer	2022
Dr Adriana Buskin Parmveer Singh Professor Craig Robson Professor Rakesh Heer	A Review of Prostate Organogenesis and a Role for iPSC-Derived Prostate Organoids to Study Prostate Development and Disease	2022
Dr Ashwin Sachdeva Dr Christopher Carey Dr Amy Vincent Professor Laura Greaves Professor Rakesh Heer et al.	Automated quantitative high‑throughput multiplex immunofuorescence pipeline to evaluate OXPHOS defects in formalin‑fxed human prostate tissue	2022
Professor Rakesh Heer	Clonal diversification and histogenesis of malignant germ cell tumours	2022
Rachel Phelps Dr Richard Gallon Christine Hayes Dr Tom Lee Professor Rakesh Heer et al.	Detection of Microsatellite Instability in Colonoscopic Biopsies and Postal Urine Samples from Lynch Syndrome Cancer Patients Using a Multiplex PCR Assay	2022
Dr Michael Grayling Professor Rakesh Heer Professor James Wason	Improving power in PSA response analyses of metastatic castration-resistant prostate cancer trials	2022
Professor Rakesh Heer	Updating and Integrating Core Outcome Sets for Localised, Locally Advanced, Metastatic, and Nonmetastatic Castration-resistant Prostate Cancer: An Update from the PIONEER Consortium	2022
Laura Wilson Professor Rakesh Heer	Development, maturation, and maintenance of human prostate inferred from somatic mutations	2021
Professor Rakesh Heer	Major Urological Cancer Surgery for Patients is Safe and Surgical Training Should Be Encouraged During the COVID-19 Pandemic: A Multicentre Analysis of 30-day Outcomes	2021
Dr Cole Sims Dr Adriana Buskin Professor Rakesh Heer	Modified CRISPR/Cas9 mediated generation of two MKK7 knockout human embryonic stem cell lines	2021
Dr Daniel Leongamornlert Professor Rakesh Heer	The mutational landscape of human somatic and germline cells	2021
Bhavan Rai Professor Luke Vale Professor Rakesh Heer	Time to Turn on the Blue Lights: A Systematic Review and Meta-analysis of Photodynamic Diagnosis for Bladder Cancer	2021
Anna Smith Dr Julia Whitehall Carla Bradshaw Dr Fiona Robertson Dr Alasdair Blain et al.	Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis	2020
Dr Anastasia Hepburn Dr Cole Sims Dr Adriana Buskin Professor Rakesh Heer	Engineering Prostate Cancer from Induced Pluripotent Stem Cells-New Opportunities to Develop Preclinical Tools in Prostate and Prostate Cancer Studies	2020
Dr Anastasia Hepburn Emma Curry Dr Mohammad Moad Laura Wilson Parmveer Singh et al.	Propagation of human prostate tissue from induced pluripotent stem cells	2020
Dr Anastasia Hepburn Laura Wilson Evangelia Kounatidou Amy Barnard Philip Berry et al.	Correction: The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance (Oncogene, (2019), 10.1038/s41388-019-0712-y)	2019
Dr Emma Clark Dr Miranda Patterson Shriya Sharma Dr Holly Fisher Denise Howel et al.	Prostate cancer androgen receptor splice variant 7 biomarker study - A multicentre randomised feasibility trial of biomarker-guided personalised treatment in patients with advanced prostate cancer (the VARIANT trial) study protocol	2019
Dr Anastasia Hepburn Laura Wilson Evangelia Kounatidou Amy Barnard Philip Berry et al.	The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance	2019
Dr Urszula McClurg Svitlana Korolchuk Dr Stuart McCracken Professor Rakesh Heer Laura Wilson et al.	Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein	2018
Professor Rakesh Heer	Laparoscopic renal surgery is here to stay	2018
Dr Craig Stamp Dr Anze Zupanic Ashwin Sachdeva Dr Elizabeth Stoll Dr Daryl Shanley et al.	Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts	2018
Dr Anastasia Hepburn Professor Rakesh Heer	Urothelial carcinoma stem cells: Current concepts, controversies, and methods	2018
Dr Mohammad Moad Professor Rakesh Heer	A Unifying Theory of Branching Morphogenesis	2017
Dr Mohammad Moad Laura Wilson Rob Pickard Emeritus Professor Doug Turnbull Professor Robert Taylor et al.	Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates	2017
Dr Mohammad Moad Gladys - Professor Craig Robson Professor Rakesh Heer	Role of Induced Pluripotent Stem Cells in Urological Disease Modeling and Repair	2017
Ashwin Sachdeva Dr Amira El-Sherif Emeritus Professor Doug Turnbull Professor Laura Greaves Professor Rakesh Heer et al.	Development of prostate intra-epithelial neoplasia in an aging series of PolgA mutator mice suggests a role for mitochondrial DNA mutations in prostate carcinogenesis	2016
Dr Rachel Pearson Professor Peter Thelwall Jim Snell Dr Piotr Pieniazek Professor Rakesh Heer et al.	Evaluation of early response to neoadjuvant chemotherapy in muscle-invasive bladder cancer using dynamic contrast-enhanced MRI and diffusion weighted MRI: MARBLE study	2016
Dr Rachel Pearson Professor Peter Thelwall Jim Snell Dr Piotr Pieniazek Professor Rakesh Heer et al.	Evaluation of early responses to neoadjuvant chemotherapy in muscle-invasive bladder cancer using a dynamic contrast-enhanced MRI and diffusion-weighted MRI: MARBLE study	2016
Nicola Lazzarini Dr Paweł Widera Dr Stuart Williamson Professor Rakesh Heer Professor Natalio Krasnogor et al.	Functional networks inference from machine learning models	2016
Professor Rakesh Heer Dr Mark Johnson	High-Risk Non-Muscle-Invasive Bladder Cancer—Therapy Options During Intravesical BCG Shortage	2016
Professor Naeem Soomro Professor Rakesh Heer	Contrast-enhanced CT in 100 clear cell renal cell cancers - an analysis of enhancement, tumour size, and survival	2015
Professor Rakesh Heer	Delays in the diagnosis and treatment of muscle invasive bladder cancer: A pilot project mapping the pathway	2015
Professor Rakesh Heer	Long-term oncological outcomes of patients undergoing neoadjuvant chemotherapy and cystectomy for muscle invasive bladder cancer	2015
Ahmed Abroaf Dr Luke Gaughan Professor Craig Robson Professor Rakesh Heer	The co-chaperone p23 promotes prostate cancer motility and metastasis	2015
Emma Curry Dr Mohammad Moad Professor Craig Robson Professor Rakesh Heer	Using induced pluripotent stem cells as a tool for modelling carcinogenesis	2015
Professor Rakesh Heer	Can we deliver randomized trials of focal therapy in prostate cancer?	2014
Dr Stuart Williamson Laura Wilson Graeme Williamson Professor Laura Greaves Dr Helen Tuppen et al.	Finding a niche. The location of human prostate stem cells	2014
Professor Nicola Curtin Professor Rakesh Heer	Investigating PARP-1 expression and activity in male and female, benign and malignant renal tissue	2014
Alistair Rogers Professor Rakesh Heer	Metastases at presentation of transitional cell muscle invasive bladder carcinoma in a 10 year series of 427 patients: is staging computed tomography of the thorax always required?	2014
Dr Mohammad Moad Dr Deepali Pal Dr Anastasia Hepburn Dr Stuart Williamson Laura Wilson et al.	A novel model of urinary tract differentiation, tissue regeneration, and disease: Reprogramming human prostate and bladder cells into induced pluripotent stem cells	2013
Dr Stuart Williamson Dr Alice Hartley Professor Rakesh Heer	A review of tasquinimod in the treatment of advanced prostate cancer	2013
Dr Stuart Williamson Dr Anastasia Hepburn Laura Wilson Professor Hing Leung Professor Craig Robson et al.	Characterisations of human prostate stem cells reveal deficiency in class I UGT enzymes as a novel mechanism for castration-resistant prostate cancer	2013
Dr Mohammad Moad Dr Anastasia Hepburn Professor Majlinda Lako Dr Deepali Pal Professor Rakesh Heer et al.	Generation of induced pluripotent stem cells from human urinary tract cells	2013
Dr Anastasia Hepburn Dr Luke Gaughan Dr Stuart Williamson Dr Deepali Pal Dr Mohammad Moad et al.	Investigating the regulation and effects on androgen receptor expression using a novel stem cell environment model of castration resistant prostate cancer	2013
Dr Stuart McCracken Professor Rakesh Heer	Penile strangulation by a substantial metal napkin ring: successful removal with medtronic midas rex® legend® stylus® drill system	2013
Dr Claire Townes Ased Ali Dr Deepali Pal Dr Stuart Williamson Professor Rakesh Heer et al.	Prostate specific antigen enhances the innate defence of prostatic epithelium against Escherichia coli infection	2013
Professor Rakesh Heer Dr Anastasia Hepburn Dr Stuart Williamson Dr Amy Kennedy Dr Amira El-Sherif et al.	Renal differentiation from adult spermatogonial stem cells	2013
Dr Deepali Pal Dr Mohammad Moad Dr Anastasia Hepburn Dr Stuart Williamson Professor Craig Robson et al.	Reply from Authors re: "Reprogramming Stromal Cell from the Urinary Tract and Prostate: A Trip to Pluripotency and Back?"	2013
Dr Deepali Pal Dr Mohammad Moad Dr Anastasia Hepburn Dr Stuart Williamson Professor Craig Robson et al.	Reply from Authors re: Felix Wezel, Jennifer Southgate. Reprogramming Stromal Cells from the Urinary Tract and Prostate: A Trip to Pluripotency and Back? Eur Urol 2013;64:762-4	2013
Dr Anastasia Hepburn Laura Wilson Professor Craig Robson Professor Rakesh Heer	Stockpiling testosterone; A unique mechanism of progression to castrate resistant disease	2013
Dr Kelly Coffey Lynsey Rogerson Claudia Ryan-Munden Dhuha Alkharaif Dr Jacqueline Stockley et al.	The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover	2013
Dr Deepali Pal Anastasia Rigas Dr Stuart Williamson Dr Mohammad Moad Dr Jane Carr-Wilkinson et al.	Induced pluripotent stem cell (iPSC) re-programming in the human prostate	2012
Professor Rakesh Heer Dr Deepali Pal David Rix Dr Mark Johnson	Secondary haemorrhage following transurethral resection of bladder tumour — is it always related to infection?	2012
Dr Deepali Pal Anastasia Rigas Dr Stuart Williamson Dr Mohammad Moad Professor Craig Robson et al.	The role of epithelial to mesenchymal transition (EMT) in iPS induction of human prostate	2012
Dr Amira El-Sherif Dr Mark Johnson Professor Naeem Soomro Professor Rakesh Heer	Accuracy of the revised 2010 TNM classification in predicting the prognosis of patients treated for renal cell cancer in the north east of England	2012
Dr Amira El-Sherif Dr Mark Johnson Professor Naeem Soomro Professor Rakesh Heer	Can the Kattan nomogram still accurately predict prognosis in renal cell carcinoma using the revised 2010 tumor-nodes-metastasis reclassification?	2012
Dr Stuart Williamson Dr Anastasia Hepburn Laura Wilson Dr Kelly Coffey Claudia Ryan-Munden et al.	Human α₂β₁^HI CD133^+VE Epithelial Prostate Stem Cells Express Low Levels of Active Androgen Receptor	2012
Dr John Blackwood Professor Laura Greaves Laura Wilson Rob Pickard Professor Majlinda Lako et al.	Lineage tracking in situ: Where are the prostate stem cells? What are they doing?	2012
Anastasia Rigas Dr Stuart Williamson Dr Amy Kennedy Dr Amira El-Sherif Professor Naeem Soomro et al.	Renal differentiation from adult spermatogonial stem cells	2012
Dr Anastasia Hepburn Dr Stuart Williamson Dr Amira El-Sherif Dr Neha Sahay Huw Thomas et al.	Side Population in Human Non-Muscle Invasive Bladder Cancer Enriches for Cancer Stem Cells That Are Maintained by MAPK Signalling	2012
Dr John Blackwood Dr Stuart Williamson Professor Laura Greaves Laura Wilson Dr Anastasia Hepburn et al.	In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells	2011
Dr Stuart Williamson Dr Anastasia Hepburn Professor Craig Robson Professor Rakesh Heer	An update on the prostate cancer stem cell model-CD133+ve stem cell enriched human prostate cells express active androgen receptor	2011
Dr Matthew Jackson Professor Rakesh Heer Dr Amira El-Sherif Dr Petros Perros	Carcinoid tumour in an ileocystoplasty: A reminder to consider native bowel disease in the reconstructed urinary tract	2011
Dr Deepali Pal Dr Stuart Williamson Professor Craig Robson Dr Anastasia Hepburn Professor Rakesh Heer et al.	Characterising potential for pluripotency induction in human prostate tissue	2011
Dr Stuart Williamson Dr Anastasia Hepburn Professor Craig Robson Professor Rakesh Heer	Comparative meta-analysis of the human prostate stem cell transcriptome demonstrates that progenitor cells are the site of malignant transformation	2011
Dr Anastasia Hepburn Dr Stuart Williamson Professor Craig Robson Professor Rakesh Heer	Side population in human bladder cancer enriches for cancer stem cells that can be targeted by MAPK inhibition	2011
Dr Deepali Pal Professor Craig Robson Dr Stuart Williamson Professor Karim Nayernia Dr Hamid Reza Soleimanpour Lichaei et al.	Stem-cell regulatory protein Piwil2 enriches for known stem-cell and cancer stem-cell markers in prostate cancer cells	2011
Dr Simon Pridgeon Professor Rakesh Heer Gordon Taylor Professor Herbie Newell Kieran O'Toole et al.	Thiothymidine combined with UVA as a potential novel therapy for bladder cancer	2011
Professor Rakesh Heer Dr Anastasia Hepburn Dr Tim Cheek Rob Pickard Professor Hing Leung et al.	Phenotypic Modulation of Human Urinary Tract Stroma-derived Fibroblasts by Transforming Growth Factor β3	2010
Dr Stuart McCracken Professor Rakesh Heer Dr Marie Mathers Benjamin Jenkins Professor Craig Robson et al.	Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer	2008
Professor Rakesh Heer Professor Craig Robson	Editorial comment on: Delta-like 1 (Dlk-1), a novel marker of prostate basal and candidate epithelial stem cells, is downregulated by notch signalling in intermediate/transit amplifying cells of the human prostate	2008
Dr Emma Clark Dr Anne Coulson Caroline Dalgliesh Dr Prabhakar Rajan Professor Rakesh Heer et al.	The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer	2008
Professor Rakesh Heer Professor Craig Robson Dr Brian Shenton Professor Hing Leung	The role of androgen in determining differentiation and regulation of androgen receptor expression in the human prostatic epithelium transient amplifying population (vol 2, pg 572, 2007)	2008
Dr Nicholas Clarke Professor Rakesh Heer Dr Tim Cheek Rob Pickard	Changing the phenotype of urethral stroma by treatment with transforming growth factor beta-3	2007
Professor Rakesh Heer Professor Craig Robson Dr Brian Shenton Professor Hing Leung	The role of androgen in determining differentiation and regulation of androgen receptor expression in the human prostatic epithelium transient amplifying population	2007
Professor Rakesh Heer Dr Anne Collins Professor Craig Robson Dr Brian Shenton Professor Hing Leung et al.	KGF suppresses α2β1 integrin function and promotes differentiation of the transient amplifying population in human prostatic epithelium	2006
Dr Arthur Mckie David Douglas Dr Sharon Olijslagers Julia Patch Mahmoud Omar et al.	Epigenetic inactivation of the human sprouty2 (hSPRY2) homologue in prostate cancer	2005
Dr Stuart McCracken Benjamin Jenkins Professor Rakesh Heer Dr Marie Mathers Professor Craig Robson et al.	Expression analysis of the MEK5/ERK5 signalling pathway in human prostate cancer	2005
Professor Rakesh Heer Dr Trevor Dorkin Thomas Griffiths Laurence Rangecroft	A prospective audit of hypospadias correction in a regional paediatric surgery centre	2004
Professor Rakesh Heer David Douglas Professor Craig Robson Professor Hing Leung	Fibroblast growth factor (FGF) 17 expression is up-regulated human prostate cancer and correlates to clinical prognosis	2004
Professor Rakesh Heer David Douglas Dr Marie Mathers Professor Craig Robson Professor Hing Leung et al.	Fibroblast growth factor 17 is over-expressed in human prostate cancer	2004
Professor Rakesh Heer Dr Anne Collins Professor Craig Robson Professor Hing Leung	Role of keratinocyte growth factor (KGF) and androgen in human prostatic epithelial stem cell differentiation	2004
Professor Rakesh Heer Dr Jyotsna Shrimankar Clive Griffith	Untitled - Letter	2004
Professor Rakesh Heer Dr Jyotsna Shrimankar Clive Griffith	Granulomatous mastitis can mimic breast cancer on clinical, radiological or cytological examination: a cautionary tale	2003
Professor Rakesh Heer	The effects of sublingual glyceryl trinitrate on walking distance in patients with intermittent claudication. A randomised, doubled-blind, placebo-controlled, cross-over study	2001
Professor Rakesh Heer Dr Stefan Plusa	How to alter surgical practice? The use of guidelines to encourage day-case haemorrhoidectomy	2000
Professor Rakesh Heer	Vascular surgical society of great britain and ireland: prospective randomized double-blind placebo-controlled crossover study to assess the effect of sublingual glyceryl trinitrate in patients with intermittent claudication	1999