Publications by Professor James Shaw - ePrints

Browsing publications by Professor James Shaw.

Newcastle Authors	Title	Year
Dr Ayat Bashir Dr Anneliese Flatt Gez Richell Professor James Shaw	A single-site feasibility randomised controlled trial comparing ‘my hypo compass’ short pyscho-educational intervention with standard care alone in individuals with type 1 diabetes and impaired awareness of hypoglycaemia	2024
Dr Rachel Stocker Alisha Gupta Dr Guy Taylor Professor James Shaw Dr Daniel West et al.	Adapting to compromised routines: Parental perspectives on physical activity and health for children and adolescents with type 1 diabetes in the UK during COVID-19 lockdown	2024
Professor James Shaw	Beyond insulin: Unraveling the complex interplay of ER stress, oxidative damage, and CFTR modulation in CFRD	2024
Professor James Shaw	Characterising impaired awareness of hypoglycaemia and associated risks through HypoA-Q: findings from a T1D Exchange cohort	2024
Dr Stuart Little Professor James Shaw	Diabetic autonomic neuropathy does not impede improvement in hypoglycaemia awareness in adults: Sub-study results from the HypoCOMPaSS trial	2024
Professor James Shaw	Editorial: Cystic fibrosis-related diabetes	2024
Professor James Shaw	Hypoglycaemia Prevention, Awareness of Symptoms, and Treatment (HypoPAST): protocol for a 24-week hybrid type 1 randomised controlled trial of a fully online psycho-educational programme for adults with type 1 diabetes	2024
Professor James Shaw	Hypoglycaemia symptom frequency, severity, burden, and utility among adults with type 1 diabetes and impaired awareness of hypoglycaemia: Baseline and 24-week findings from the HypoCOMPaSS study	2024
Dr Nicole Kattner Yara Al-Selwi George Merces Professor James Shaw	IGFBP7 is upregulated in islets from T2D donors and reduces insulin secretion	2024
Professor James Shaw	Insulin sensitivity, disposition index and insulin clearance in cystic fibrosis: a cross-sectional study	2024
Ayat Bashir Professor James Shaw	Preventing severe hypoglycemia in adults with type 2 diabetes (PHT2): Design, delivery and evaluation framework for a randomized controlled trial	2024
Phil Mawson Dr Guy MacGowan Professor Neil Sheerin Professor Andrew Fisher Professor James Shaw et al.	SIGNET: protocol for a multicentre, single-blind prospective, group sequential, randomised controlled trial to evaluate the benefits of a single dose of simvastatin given to potential organ donors declared dead by neurological criteria on outcomes in organ recipients	2024
Dr Guy Taylor Kieran Smith Jadine Scragg Professor James Shaw Dr Daniel West et al.	The metabolome as a diagnostic for maximal aerobic capacity during exercise in type 1 diabetes	2024
Professor James Shaw	Beta-cell death and dysfunction drives hyperglycaemia in organ donors	2023
Professor James Shaw	Changes in attitudes to awareness of hypoglycaemia during a hypoglycaemia awareness restoration programme are associated with avoidance of further severe hypoglycaemia episodes within 24 months: the A2A in HypoCOMPaSS study	2023
Professor James Shaw	Characterization of impaired beta and alpha cell function in response to an oral glucose challenge in cystic fibrosis: a cross-sectional study	2023
Professor James Shaw Dr Bill Scott	The Relevance of Advanced Therapy Medicinal Products in the Field of Transplantation and the Need for Academic Research Access: Overcoming Bottlenecks and Claiming a New Time	2023
Dr Zoe Bond Ayat Bashir Dr Rachel Stocker Professor James Shaw	Validation of Igls Criteria for Islet Transplant Functional Status Using Person-Reported Outcome Measures in a Cross-Sectional Study	2023
Dr Guy Taylor Andy Shaw Kieran Smith Professor James Wason Professor Emma Stevenson et al.	Capturing the real-world benefit of residual β-cell function during clinically important time-periods in established Type 1 diabetes	2022
Nicola Dyson Dr Nicole Kattner Minna Honkanen-Scott Bethany Hunter Jennifer Doyle et al.	Development and Application of a Semi quantitative Scoring Method for Ultrastructural Assessment of Acute Stress in Pancreatic Islets	2022
Dr Francesco Zummo Merilin Georgiou Kirsty Cullen Minna Honkanen-Scott Professor James Shaw et al.	Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis	2022
Professor James Shaw	Long-term health after Severe Acute Malnutrition in children and adults- the role of the Pancreas (SAMPA): Protocol	2022
Xuefei Yu Dr Catherine Arden Dr Rolando Berlinguer Palmini Dr Chun Chen Carla Bradshaw et al.	Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation	2022
Dr Deborah Cornell Dr Satomi Miwa Dr Maria Georgiou Dr Scott Anderson Minna Honkanen-Scott et al.	Pseudoislet aggregation of pancreatic β-cells improves glucose stimulated insulin secretion by altering glucose metabolism and increasing ATP production.	2022
Dr Guy Taylor Andy Shaw Kieran Smith Professor James Shaw Dr Daniel West et al.	Type 1 diabetes patients with different residual beta-cell function but similar age, HBA1c, and cardiorespiratory fitness have differing exercise-induced angiogenic cell mobilisation	2022
Professor Derek Manas Professor James Shaw Professor Colin Wilson Steven White	105.2: Pancreas and Islet Transplantation in the UK During the COVID-19 Era	2021
Professor James Shaw	Associations between glucose tolerance, insulin secretion, muscle and fat mass in cystic fibrosis	2021
Dr Aaron Liew Dr Augustin Brooks Dr Anneliese Flatt Professor James Shaw	Autoreactive T cell profiles are altered following allogeneic islet transplantation with alemtuzumab induction and re-emerging phenotype is associated with graft function	2021
Andrea Masi Dr Beate Haugk Professor Chris Lamb Professor Linda Sharp Professor James Shaw et al.	Endoscopic ultrasound (EUS) guided fine needle biopsy (FNB) formalin preserved paraffin embedded (FFPE) pancreatic tissue samples are a potential resource for microbiota analysis	2021
Professor James Shaw	Evaluation of currently available screening methods for cystic fibrosis-related diabetes	2021
Dr Rachel Stocker Professor James Shaw Dr Guy Taylor Professor Miles Witham Dr Daniel West et al.	EXercise to Prevent frailty and Loss Of independence in insulin treated older people with DiabetEs (EXPLODE): protocol for a feasibility randomised controlled trial (RCT)	2021
Nicola Dyson Dr Nicole Kattner Minna Honkanen-Scott Bethany Hunter Tracey Davey et al.	P.112: Ultrastructural Assessment of the Associations of Obesity and Established Diabetes in Human Pancreata	2021
Dr Ruth Owen Emily Thompson Professor James Shaw Professor Colin Wilson Steven White et al.	P.137: Multi-centre UK Analysis After SPK in Recipients With Type 2 Diabetes Mellitus	2021
Dr Anneliese Flatt Professor James Shaw	Pancreatic islet reserve in type 1 diabetes	2021
Professor James Shaw	Restoring normal islet mass and function in type 1 diabetes through regenerative medicine and tissue engineering	2021
Professor James Shaw	Screening Methods for Diagnosing Cystic Fibrosis-Related Diabetes: A Network Meta-Analysis of Diagnostic Accuracy Studies	2021
Dr Anneliese Flatt Professor James Shaw	The impact of islet mass, number of transplants, and time between transplants on graft function in a national islet transplant program	2021
Dr Guy Taylor Andy Shaw Kieran Smith Tess Capper Jadine Scragg et al.	Type 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated	2021
Yara Al-Selwi Professor James Shaw Dr Nicole Kattner	Understanding the Pancreatic Islet Microenvironment in Cystic Fibrosis and the Extrinsic Pathways Leading to Cystic Fibrosis Related Diabetes	2021
Professor James Shaw Steven White	US food and drug administration (FDA) panel endorses islet cell treatment for type 1 diabetes: A pyrrhic victory?	2021
Dr Ahmad Al-Mrabeh Dr Kieren Hollingsworth Professor James Shaw Professor Roy Taylor	2-year remission of type 2 diabetes and pancreas morphology: a post-hoc analysis of the DiRECT open-label, cluster-randomised trial	2020
Dr Ahmad Al-Mrabeh Dr Kieren Hollingsworth Professor James Shaw Professor Roy Taylor	2-year remission of type 2 diabetes and pancreas morphology: a post-hoc analysis of the DiRECT open-label, cluster-randomised trial	2020
Dr Guy Taylor Kieran Smith Andy Shaw Professor Emma Stevenson Professor James Shaw et al.	Bone turnover and metabolite responses to exercise in people with and without long-duration type 1 diabetes: a case-control study	2020
Dr Aaron Liew Dr Anneliese Flatt Ruth Wood Professor James Shaw	Characterization of pre-transplant psychosocial burden in an integrated national islet transplant program	2020
Dr Nicole Kattner Nicola Dyson Dr Yvonne Bury Dr Dina Tiniakos Tracey Davey et al.	Development and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas	2020
Professor James Shaw	Donor insulin use predicts beta-cell function after islet transplantation	2020
Professor James Shaw Dr Aaron Liew	Efficacy and safety of a sodium-glucose co-transporter-2 inhibitor versus placebo as an add-on therapy for people with type 2 diabetes inadequately treated with metformin and a dipeptidyl peptidase-4 inhibitor: a systematic review and meta-analysis of randomised controlled trials	2020
Dr Michael White Dr Rashmi Maheshwari Dr Scott Anderson Dr Rolando Berlinguer Palmini Claire Jones et al.	In situ analysis reveals that CFTR is expressed in only a small minority of β-cells in normal adult human pancreas	2020
Dr Guy Taylor Kieran Smith Tess Capper Jadine Scragg Dr Ayat Bashir et al.	Postexercise Glycemic Control in Type 1 Diabetes Is Associated With Residual β-Cell Function	2020
Sarah Armour Dr Scott Anderson Dr Yuchun Ding Dr Christopher Carey Dr Rashmi Maheshwari et al.	Reduced expression of the co-regulator TLE1 in type 2 diabetes is associated with increased islet α-cell number	2020
Professor James Shaw Dr Aaron Liew	Targeting CXCR1/2 does not improve insulin secretion after pancreatic islet transplantation: A phase 3, double-blind, randomized, placebo-controlled trial in type 1 diabetes	2020
Dr Stuart Little Professor James Shaw	Development and psychometric validation of the novel Glucose Monitoring Experiences Questionnaire (GME-Q) among adults with type 1 diabetes	2019
Dr Bill Scott Professor Derek Manas Professor James Shaw	Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling	2019
Dr Anneliese Flatt Dr Stuart Little Dr Thomas Chadwick Ruth Wood Professor James Shaw et al.	Predictors of Recurrent Severe Hypoglycemia in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia During the HypoCOMPaSS Study	2019
Dr Stuart Little Professor James Shaw	Satisfaction with the Use of Different Technologies for Insulin Delivery and Glucose Monitoring Among Adults with Long-Standing Type 1 Diabetes and Problematic Hypoglycemia: 2-Year Follow-Up in the HypoCOMPaSS Randomized Clinical Trial	2019
Dr Rashmi Maheshwari Professor James Shaw Dr Michael White	Short-term CFTR inhibition reduces islet area in C57BL/6 mice	2019
Dr Anneliese Flatt Steven White Professor James Shaw	β-Cell and renal transplantation options for diabetes	2019
Professor James Shaw Steven White	Defining Outcomes for β-cell Replacement Therapy in the Treatment of Diabetes: A Consensus Report on the Igls Criteria from the IPITA/EPITA Opinion Leaders Workshop	2018
Professor James Shaw	Does islet size really influence graft function following clinical islet transplantation?	2018
Dr Scott Anderson Dr Ali Aldibbiat Professor James Shaw	Improved Beta-Cell Differentiation and Function in Isolated Islets Established in Dynamic Culture to Reduce Hypoxia	2018
Dr Scott Anderson Dr Michael White Sarah Armour Rashmi Maheshwari Dr Dina Tiniakos et al.	Loss of end-differentiated β-cell phenotype following pancreatic islet transplantation	2018
Dr Stuart Little Dr Deborah Stocken Emerita Professor Sally Marshall Professor James Shaw	Sustained reduction in severe hypoglycemia in adults with type 1 diabetes complicated by impaired awareness of hypoglycemia: 2-year follow-up in the HypoCOMPaSS randomized clinical trial	2018
Professor James Shaw	Donor-Specific Antibodies - The Devil Is in the Detail	2017
Dr Francesco Zummo Kirsty Cullen Minna Honkanen-Scott Professor James Shaw Professor Penny Lovat et al.	Glucagon-like peptide-1 protects pancreatic beta-cells from death by increasing autophagic flux and restoring lysosomal function	2017
Professor Christopher Stewart Professor Mark Walker Professor Emma Stevenson Professor James Shaw Dr Daniel West et al.	Gut microbiota of Type 1 diabetes patients with good glycaemic control and high physical fitness is similar to people without diabetes: an observational study	2017
Professor James Shaw	The big pet diabetes survey: Perceived frequency and triggers for euthanasia	2017
Sarah Armour Dr Scott Anderson Professor James Shaw Dr Michael White	A Novel Role for Tle3 in Maintaining Beta Cell Identity	2016
Alexander Popov Dr Bill Scott Dr Jinju Chen Professor James Shaw Professor Kenneth Dalgarno et al.	3D manufactured islet micro-tissues for the treatment of type-1 diabetes	2016
Professor Mark Walker Professor James Shaw Professor Emma Stevenson Dr Daniel West	Administering a small rapid-acting insulin bolus 3 h after eating a mixed macronutrient meal improves postprandial glucose control, without hypoglycaemia, in people with Type 1 diabetes	2016
Professor Mark Walker Dr Dean Allerton Professor Emma Stevenson Professor James Shaw Dr Daniel West et al.	Carbohydrate counting at meal time followed by a small secondary postprandial bolus injection at 3 hours prevents late hyperglycemia, without hypoglycemia, after a high-carbohydrate high-fat meal in Type 1 diabetes	2016
Dr Stuart Little Professor James Shaw	Characterizing problematic hypoglycaemia: iterative design and preliminary psychometric validation of the Hypoglycaemia Awareness Questionnaire (HypoA-Q)	2016
Dr Bill Scott Minna Honkanen-Scott Dr Julian De Havilland Professor Derek Manas Professor James Shaw et al.	Diversifying the Indications for Pancreas Resection and Autologous Islet Cell Transplantation (IAT) in both Adults and Children	2016
Dr Scott Anderson Sarah Armour Dr Michael White Dr Thomas Berney Professor James Shaw et al.	Evidence for Beta Cell Dedifferentiation as a Cause for Sustained Graft Dysfunction Following Peri Engraftment Hypoxia in Clinical Islet Transplantation	2016
Minna Honkanen-Scott Dr Julian De Havilland Professor Derek Manas Professor James Shaw Professor Anne Dickinson et al.	Expanding the indications for pancreas resection and autologous islet cell transplantation (IAT) in both adults and children	2016
Dr Aaron Liew Vish Bhattacharya Professor James Shaw Professor Gerard Stansby	Gene therapy for peripheral arterial disease (Protocol)	2016
Dr Francesco Zummo Kirsty Cullen Professor Penny Lovat Professor James Shaw Dr Catherine Arden et al.	Glucagon-like peptide-1 requires EPAC activity to restore autophagy and protect pancreatic beta cells from cell death	2016
Dr Scott Anderson Dr Helen Marshall Professor James Shaw	Hypoxia-induced beta cell dedifferentiation: the missing link in islet transplant dysfunction?	2016
Sarah Armour Professor James Shaw Dr Michael White	Limitation of glucotoxicity-induced beta-cell dedifferentiation and alpha-cell transition following Nkx6.1 overexpression	2016
Dr Stuart Little Professor James Shaw	Low-blood glucose avoidance training improves glycemic variability in adults with type 1 diabetes complicated by impaired awareness of hypoglycemia: HypoCOMPaSS trial	2016
Dr Helen Marshall Professor James Shaw	Methylation speciﬁc cell free DNA to monitor islet autoimmunity in Type 1 diabetes	2016
Dr Helen Marshall Professor James Shaw	Methylation specific cell free DNA to monitor islet autoimmunity in Type 1 diabetes	2016
Dr Stuart Little Dr Thomas Chadwick Dr Deborah Stocken Catherine Brennand Emerita Professor Sally Marshall et al.	Recovery of hypoglycemia awareness in longstanding type 1 diabetes: A multicenter 2×2 factorial randomized controlled trial comparing insulin pump with multiple daily injections and continuous with conventional glucose selfmonitoring (HypoCOMPaSS)	2016
Dr Michael White Professor James Shaw Professor Roy Taylor	Type 2 Diabetes: The Pathologic Basis of Reversible β-Cell Dysfunction	2016
Dr Gus Brooks Dr Aaron Liew Dr Helen Marshall Dr Ali Aldibbiat Professor Neil Sheerin et al.	De Novo Donor-Specific HLA Antibodies Are Associated With Rapid Loss of Graft Function Following Islet Transplantation in Type 1 Diabetes	2015
Professor Mark Walker Professor Mike Trenell Professor James Shaw Dr Daniel West	A combined basal-bolus insulin dose reduction strategy for preventing exercise-induced hypoglycaemia does not cause hormonal, metabolic or inflammatory disturbances in Type 1 diabetes	2015
Professor Mark Walker Professor Mike Trenell Professor James Shaw	A novel strategy that prevents early- and late-onset nocturnal hypoglycaemia following evening exercise in Type 1 diabetes	2015
Dr Francesco Zummo Kirsty Cullen Professor Penny Lovat Professor James Shaw Dr Catherine Arden et al.	An emerging role for autophagy in the regulation of beta cell survival by glucagon-like peptide-1	2015
Sarah Armour Professor James Shaw Dr Michael White	An in vitro model of beta cell de-differentiation and potential alpha cell reprogramming	2015
Dr Stuart Little Professor James Shaw	Associations with hyperglycaemia avoidance among adults with long-standing Type 1 diabetes and impaired awareness of hypoglycaemia: baseline characteristics from the HypoCOMPaSS Study	2015
Dr Stuart Little Professor James Shaw	Cardiac autonomic regulation during experimental hypoglycaemia in type 1 diabetes with impaired awareness of hypoglycaemia	2015
Dr Stuart Little Professor James Shaw	Cardiac autonomic regulation during experimental hypoglycaemia in Type 1 diabetes with impaired awareness of hypoglycaemia (IAH)	2015
Dr Aaron Liew Vish Bhattacharya Professor James Shaw Professor Gerard Stansby	Cell Therapy for Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials	2015
Professor Mark Walker Professor James Shaw Professor Emma Stevenson Dr Daniel West	Comparison of appetite responses to high- and low-glycemic index postexercise meals under matched insulinemia and fiber in type 1 diabetes	2015
Dr Scott Anderson Dr Michael White Dr Helen Marshall Professor James Shaw	Contaminating exocrine tissue as a source of MCP-1 in islet transplantation	2015
Dr Augustin Brooks Emeritus Professor Philip Home Dr Nick Steen Professor James Shaw	Demonstration of an Intrinsic Relationship Between Endogenous C-Peptide Concentration and Determinants of Glycemic Control in Type 1 Diabetes Following Islet Transplantation	2015
Dr Bill Scott Minna Honkanen-Scott Dr Julian De Havilland Hany Gabra Richard Charnley et al.	Expanding the indications for paediatric and adult autologous islet transplantation	2015
Dr Francesco Zummo Kirsty Cullen Professor Penny Lovat Professor James Shaw Dr Catherine Arden et al.	Glucagon-like peptide 1 protects pancreatic beta cells from programmed cell death: a role for autophagy	2015
Dr Stuart Little Professor James Shaw	Hypoglycaemia avoidance training improves glucose variability in Type 1 diabetes (HypoCOMPaSS Study)	2015
Dr Daniel West Professor Mark Walker Professor James Shaw Dr Fahad Ahmed Stephanie Wijaya et al.	Inflammation and the acute endothelial progenitor cell response to submaximal running exercise in males with and without Type 1 diabetes	2015
Professor Mark Walker Professor Emma Stevenson Professor James Shaw Dr Daniel West	Insulin therapy and dietary adjustments to normalise glycaemia and prevent nocturnal hypoglycaemia after evening exercise in Type 1 diabetes: a randomized controlled trial	2015
Dr Michael White Sarah Armour Professor James Shaw	Limiting human beta cell de-differentiation by small molecule inhibitors of the transforming growth factor beta (TGF-beta) pathway	2015
Professor Mark Walker Professor James Shaw Dr Daniel West	Subjective and hormonal appetite responses to high and low glycaemic index post-exercise meals, under matched insulinaemia and fibre in Type 1 diabetes	2015
Dr Julian De Havilland Minna Honkanen-Scott Richard Charnley Professor Derek Manas Professor James Shaw et al.	Successful autologous islet transplantation post-frey's procedure using a side-vented 'therapeutic infusion needle' for improved enzyme delivery	2015
Professor Mark Walker Dr Fahad Ahmed Stephanie Wijaya Professor James Shaw Dr Jolanta Weaver et al.	The inflammation, vascular repair and injury responses to exercise in fit males with and without Type 1 diabetes: an observational study	2015
Professor James Shaw	The UK Pancreas Allocation Scheme for Whole Organ and Islet Transplantation	2015
Professor Mark Walker Professor Mike Trenell Professor Emma Stevenson Professor James Shaw Dr Daniel West et al.	A Low-Glycemic Index Meal and Bedtime Snack Prevents Postprandial Hyperglycemia and Associated Rises in Inflammatory Markers, Providing Protection From Early but Not Late Nocturnal Hypoglycemia Following Evening Exercise in Type 1 Diabetes	2014
Dr Stuart Little Professor James Shaw	Coefficient of variation from continuous glucose monitoring is associated with the frequency of hypoglycaemia in Type 1 diabetes complicated by impaired awareness of hypoglycaemia: baseline analysis of the HypoCOMPaSS study group	2014
Professor James Shaw	Examining Glycaemic Control and Variability Utilising the Medtronic Continuous Glucose Monitoring System (CGMS) In Pre And Post CSII Therapy	2014
Dr Gus Brooks Professor James Shaw	Home Urine C-Peptide Creatinine Ratio Can Be Used to Monitor Islet Transplant Function	2014
Dr Michael White Professor James Shaw	Involvement of Notch signaling in Human Beta-Cell Dedifferentiation	2014
Professor James Shaw David Talbot	Portal Venous Oxygen Persufflation of the Donation after Cardiac Death pancreas in a rat model is superior to static cold storage and hypothermic machine perfusion	2014
Dr Stuart Little Dr Thomas Chadwick Dr Deborah Stocken Catherine Brennand Emerita Professor Sally Marshall et al.	Recovery of Hypoglycemia Awareness in Long-Standing Type 1 diabetes: A Multicenter 2x2 Factorial Randomized Controlled Trial Comparing Insulin Pump with Multiple Daily Injections and Continuous with Conventional Glucose Self-Monitoring (HypoCOMPaSS)	2014
Dr Stuart Little Dr Thomas Chadwick Dr Deborah Stocken Catherine Brennand Emerita Professor Sally Marshall et al.	Response to Comment on Little et al. Recovery of Hypoglycemia Awareness in Long-standing Type 1 Diabetes: A Multicenter 2 x 2 Factorial Randomized Controlled Trial Comparing Insulin Pump With Multiple Daily Injections and Continuous With Conventional Glucose Self-monitoring (HypoCOMPaSS). Diabetes Care 2014;37:2114-2122	2014
Dr Stuart Little Professor James Shaw	Severe hypoglycaemia in type 1 diabetes mellitus: underlying drivers and potential strategies for successful prevention	2014
Dr Emma Fairhall Dr Karen Wallace Steven White Professor James Shaw Professor Alastair Burt et al.	Adult human exocrine pancreas differentiation to hepatocytes – potential source of a human hepatocyte progenitor for use in toxicology research	2013
Dr Gus Brooks Dr Ali Aldibbiat Professor Mark Walker Professor James Shaw	Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations	2013
Dr Michael White Dr Helen Marshall Professor James Shaw	Beta cell dedifferentiation: Evidence for ductal progenitors as a source of new beta cells?	2013
Dr Michael White Dr Helen Marshall Dr Aimen Amer Dr Trevor Booth Steven White et al.	Expression of Mesenchymal and α-Cell Phenotypic Markers in Islet β-Cells in Recently Diagnosed Diabetes	2013
Dr Helen Marshall Professor James Shaw Professor Derek Manas	Human Pancreas Persufflation Ameliorates Hypoxia-Induced Impairment of Islet Function Post-Isolation	2013
Professor James Shaw	International workshop: islet transplantation without borders enabling islet transplantation in Greece with international collaboration and innovative technology	2013
Professor James Shaw	Islet Activity and Outcomes in the United Kingdom	2013
Professor James Shaw	Islet transplantation and return of hypoglycaemic awareness: the same Driver and Vehicle Licensing Agency (DVLA) rules still apply	2013
Dr Stuart Little Professor James Shaw	Patients with longstanding type 1 diabetes show improved self awareness of hypoglycaemia measured during clamped hypoglycaemic challenges after a six month intensive treatment period in the HypoCOMPASS Study: comparison of optimised multiple daily injections (MDI) and continuous insulin infusion therapy (CSII) with or without adjunctive real-time continuous glucose monitoring (RTCGM)	2013
Afsara Ahmmed Dr Augustin Brooks Dr Kieren Hollingsworth Professor Mike Trenell Professor James Shaw et al.	Quantification of hepatic steatosis before and after intraportal pancreatic islet transplantation	2013
Dr Helen Marshall Professor James Shaw	Rapid detection of hypoxic islet stress by oxygen consumption rate using a standardised beta cell model	2013
Dr Augustin Brooks Dr Ali Aldibbiat Professor Mark Walker Professor James Shaw	Restoration of endogenous C-peptide by islet transplantation is associated with increased duration of normoglycaemia and reduced blood glucose variability in recipients with Type 1 diabetes	2013
Dr Stuart Little Annette Lane Dr Thomas Chadwick Emerita Professor Sally Marshall Professor James Shaw et al.	Restoration of self-awareness of hypoglycemia in adults with long-standing Type 1 diabetes: hyperinsulinemic-hypoglycemic clamp substudy results from the HypoCOMPaSS trial	2013
Dr Gus Brooks Professor James Shaw	Urine c-peptide creatinine ratio can be used for home monitoring of islet transplant function	2013
Dr Stuart Little Dr Thomas Chadwick Catherine Brennand Dr Julia Stickland Emerita Professor Sally Marshall et al.	Comparison of Optimised MDI versus Pumps with or without Sensors in Severe Hypoglycaemia (the Hypo COMPaSS trial)	2012
Dr Matthew Thomas Professor Colin Wilson Professor Derek Manas Professor Mark Walker Professor James Shaw et al.	Endoscopic Botulinum Toxin Injection for the Treatment of Diabetic Gastropathy in Pancreas and Islet-cell Transplant Patients	2012
Professor James Shaw Dearbhaile Church	Evaluation of a Quality-of-Life Tool for Dogs with Diabetes Mellitus	2012
Dr Susan Campbell Dr Ali Aldibbiat Christopher Huggins Dr Audrey Brown Professor James Shaw et al.	Novel diabetes mellitus treatment: mature canine insulin production by canine striated muscle through gene therapy	2012
Dr Susan Campbell Professor James Shaw Dr Marsha Cochrane	Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)	2012
Dr Ali Aldibbiat Dr Graham Holliman Linda Ferguson Kenneth Brigham Dr Josephine Wardle et al.	Validation of Islet Transport From a Geographically Distant Isolation Center Enabling Equitable Access and National Health Service Funding of a Clinical Islet Transplant Program for England	2012
Dr Stuart Little Professor James Shaw Emeritus Professor Philip Home	Hypoglycemic rates with basal insulin analogs	2011
Professor James Shaw	Insulin Pump Therapy With Automated Insulin Suspension in Response to Hypoglycemia: Reduction in nocturnal hypoglycemia in those at greatest risk	2011
Dr Michael White Hussain Al-Turaifi Dr Graham Holliman Dr Ali Aldibbiat Aiman Mahmoud et al.	Pluripotency-associated stem cell marker expression in proliferative cell cultures derived from adult human pancreas	2011
Dr Karen Wallace Professor James Shaw Professor Alastair Burt Professor Matthew Wright	Prolonged glucocorticoid exposure results in the appearance of hepatocytes in the adult pancreas	2011
Professor James Shaw Dr Fiona Campbell	ABCD position statement on continuous glucose monitoring: Use of glucose sensing in outpatient clinical diabetes care	2010
Steven White Professor James Shaw Emeritus Professor Paul Flecknell Professor Alastair Burt Professor Matthew Wright et al.	Chronic elevated systemic glucocorticoid results in widespread pancreatic-hepatic trans-differentiation in vivo	2010
Professor Danny MacKinnon Professor James Shaw	Devolution as Process: Institutional Structures, State Personnel and Transport Policy in the United Kingdom	2010
Dr Shaikh Abdul Shakoor Dr Ali Aldibbiat Lorna Ingoe Dr Susan Campbell Dr Latika Sibal et al.	Endothelial Progenitor Cells in Subclinical Hypothyroidism: The Effect of Thyroid Hormone Replacement Therapy	2010
Professor James Shaw	Evaluation of a Quality-of-Life Tool for Cats with Diabetes Mellitus	2010
Professor Danny MacKinnon Professor James Shaw	Labour, organisational rescaling and the politics of production: union renewal in the privatised rail industry	2010
Professor Matthew Wright Dr Karen Wallace Professor James Shaw Professor Alastair Burt Steven White et al.	Long term glucocorticoid therapy leads to pancreatic acinar trans-differentiation into hepatocyte-like cells	2010
Professor James Shaw	Patient-reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in Type 1 diabetes: a systematic review	2010
Christopher Huggins Professor James Shaw	Transgene expression in mononuclear muscle cells not infiltrating inflammatory cells following intramuscular plasmid gene electrotransfer	2010
Professor James Shaw	Algorithm for the introduction of rapid-acting insulin analogues in patients with type 2 diabetes on basal insulin therapy	2009
Dr Karen Wallace Professor James Shaw Professor Alastair Burt Professor Matthew Wright	Chronic Elevated Systemic Glucocorticocoid Results in Widespread Pancreatic-Hepatic Trans-Differentiation In Vivo	2009
Dr Latika Sibal Dr Ali Aldibbiat Dr Sharad Agarwal Crispian Oates Dr Salman Razvi et al.	Circulating endothelial progenitor cells, endothelial function, carotid intima-media thickness and circulating markers of endothelial dysfunction in people with type 1 diabetes without macrovascular disease or microalbuminuria	2009
Dr Ali Aldibbiat Susan Stamp Dr Brian Shenton Professor James Shaw Dr Noel Carter et al.	Improved Preservation of Non Heart-Beating- Donor Pancreases Prior to Islet Isolation Using Portal Venous Oxygen Persufflation.	2009
Aiman Mahmoud Dr Catherine Arden Dr Audrey Brown Dr Susan Campbell Dr Ali Aldibbiat et al.	Muscle targeted gene therapy for diabetes mellitus: role of proteasomal decay in mutant proinsulin plasmid efficiency	2009
Aiman Mahmoud Dr Ali Aldibbiat Hussain Al-Turaifi Christopher Huggins Professor James Shaw et al.	Muscle-targeted gene transfer enables continuous secretion of GLP-1 and exendin-4 in mice	2009
Steven White Professor James Shaw	Pancreas transplantation	2009
Dr Ali Aldibbiat Susan Stamp Dr Brian Shenton Professor James Shaw David Talbot et al.	Portal venous oxygen persufflation for the preservation of non heart-beating-donor pancreases prior to islet isolation	2009
Dr Catherine Arden Dr Laura Hampson Professor James Shaw Dr Ali Aldibbiat Dr Graham Holliman et al.	A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic β-cells	2008
Dr Ali Aldibbiat Dr Susan Campbell Christopher Huggins Professor James Shaw	Development of muscle targeted gene therapy with a mutant canine proinsulin plasmid for the treatment of canine diabetes mellitus	2008
Dr Ali Aldibbiat Dr Graham Holliman Dr Susan Campbell Professor James Shaw	Expression of pluripotent stem cell markers within intact adult human pancreas and proliferative adherent cell cultures derived from digested pancreas	2008
Aiman Mahmoud Dr Ali Aldibbiat Dr Susan Campbell Dr Graham Holliman Dr Kathleen Scougall et al.	Expression, storage and rapid regulated secretion of active glucagon like peptide-1 following muscle-targeted gene transfer	2008
Dr Ali Aldibbiat Dr Graham Holliman Hussain Al-Turaifi Dr Susan Campbell Professor James Shaw et al.	Generation of insulin-synthesising pseudo-islets from adult stem cell cultures derived from the human pancreas	2008
Dr Ali Aldibbiat Dr Kathleen Scougall Dr Susan Campbell Professor James Shaw	Inability to process and store proinsulin in transdifferentiated pancreatic acinar cells lacking the regulated secretory pathway	2008
Aiman Mahmoud Dr Ali Aldibbiat Christopher Huggins Dearbhaile Church Professor James Shaw et al.	Muscle-targeted gene therapy for the treatment of diabetes mellitus: Investigating the role of the immune system when employing mutant (pro)insulin	2008
Dr Susan Campbell Dr Ali Aldibbiat Christopher Huggins Professor James Shaw	Novel furin-cleavable human insulin construct (hppI5) for muscle targeted gene therapy in diabetes mellitus	2008
Dr Susan Campbell Dr Ali Aldibbiat Dr Clive Butler Professor James Shaw	Selenium stimulates pancreatic beta-cell gene expression and enhances islet function	2008
Dr Latika Sibal Dr Ali Aldibbiat Crispian Oates Dr Jolanta Weaver Professor James Shaw et al.	The influence of the presence of retinopathy on the circulating endothelial progenitor cell counts, endothelial function and carotid intima-media thickness in type I diabetes	2008
Dr Ali Aldibbiat Dr Mike Cox Dr Nicola Leech Professor James Shaw	A randomized pilot study in type 1 diabetes complicated by severe hypoglycaemia, comparing rigorous hypoglycaemia avoidance with insulin analogue therapy, CSII or education alone	2007
Dr Catherine Arden Dr Alison Trainer Dr Kathleen Scougall Professor James Shaw Professor Loranne Agius et al.	Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic β-cells: Evidence for cellular instability of catalytic activity	2007
Professor James Shaw	Does one size really fit all? Only by considering individual preferences and priorities will the true impact of insulin pump therapy on quality of life be determined	2007
Dr Latika Sibal Dr Ali Aldibbiat Dr Jolanta Weaver Dr Salman Razvi Crispian Oates et al.	Endothelial dysfunction and circulating endothelial progenitor cells in young people with type 1 diabetes	2007
Dr Latika Sibal Dr Ali Aldibbiat Dr Sharad Agarwal Dr Jolanta Weaver Dr Salman Razvi et al.	Endothelial dysfunction, carotid intima media thickness and circulating endothelial progenitor cells in young people with Type 1 diabetes	2007
Dr Ali Aldibbiat Dr Brian Shenton Professor James Shaw Dr Noel Carter Professor Derek Manas et al.	Hypothermic machine perfusion for preservation and viability assessment of porcine non-heart-beating-donor pancreas: Initial results	2007
Christopher Huggins Emeritus Professor John Kirby Professor James Shaw	In vitro and in vivo evaluation of intrinsic immunogenicity of reporter and insulin gene therapy plasmids	2007
Dr Ali Aldibbiat Professor Anne Dickinson Professor Derek Manas Professor James Shaw	[abstract] Confirmation of maintained sterility, viability and function in clinical-grade human islets following transport from an approved geographically-distance isolation facility	2006
Dr Catherine Arden Dr Kathleen Scougall Professor James Shaw Professor Loranne Agius	[abstract] Generation of MIN6 stable cell lines expressing GFP-tagged glucokinase for cellular analysis of glucokinase mutants	2006
Dr Latika Sibal Dr Ali Aldibbiat Ian Harvey Dr Brian Shenton Dr Graham Holliman et al.	[abstract] Identification and quantification of circulating endothelial progenitor cells in individuals with Type 1 diabetes and non-diabetic controls	2006
Dr Ali Aldibbiat Dr Nicola Leech Professor James Shaw	[abstract] Safety and efficacy of continuous subcutaneous insulin infusion therapy in relation to pre-intervention HbA1c	2006
Dr Catherine Arden Professor James Shaw Professor Loranne Agius	Catalytic instability of the glucokinase MODY-2 mutants V62M and G72R in pancreatic beta cells	2006
Dr Graham Holliman Dr Ali Aldibbiat Dr Susan Campbell Professor Derek Manas Professor Majlinda Lako et al.	Expression of the pluripotent stem cell marker OCT-4 in normal adult human pancreas	2006
Professor James Shaw	Plasmid-mediated muscle-targeted gene therapy for circulating therapeutic protein replacement: A tale of the tortoise and the hare?	2006
Marcus Wilson Dr Kathleen Scougall Dr Elizabeth McIntyre Professor James Shaw	Storage, processing and rapid regulated secretion of insulin following gene transfer to human muscle	2006
Professor James Shaw David Talbot	Audit of diabetes in a renal transplant population	2005
Dr Ali Aldibbiat Dr Kathleen Scougall Dr Susan Campbell Professor James Shaw	Proinsulin overexpression as a tool for characterization of β-cell phenotype in transdifferentiation studies	2005
Jarupa Ratanamart Christopher Huggins Professor James Shaw	Tetracycline-regulated human proinsulin secretion following plasmid-mediated gene transfer to muscle	2005
Dr Kathleen Scougall Dr Elizabeth McIntyre Professor James Shaw	Tetracycline-regulated secretion of human (pro)insulin following plasmid-mediated transfection of human muscle	2005
Dr Ali Aldibbiat Dr Kathleen Scougall Dr Susan Campbell Professor James Shaw	Characterisation of pancreatic acinar cells for endocrine potential and determination of proinsulin processing and secretion following transfection with a human preproinsulin gene	2004
Jarupa Ratanamart Dr Kathleen Scougall Emeritus Professor John Kirby Professor James Shaw	Establishment of an in vitro bioassay for immunogenicity of bacterial lipopolysaccharide and unmethylated CpG motifs in plasmid-derived gene therapy vectors	2004
Robert Campbell Professor James Shaw	Generation of glucose-responsive insulin expression constructs for use in a muscle-targeted gene therapy approach to the treatment of diabetes mellitus	2004
Marcus Wilson Dr Kathleen Scougall Dr Elizabeth McIntyre Emeritus Professor Steve Yeaman Professor Mark Walker et al.	Towards muscle-targeted gene therapy for diabetes: Tetracycline-repressible transcriptional regulation of (pro)insulin secretion in human muscle	2004
Magdalene Wilson Dr Elizabeth McIntyre Dr Kathleen Scougall Professor Mark Walker Emeritus Professor Steve Yeaman et al.	Tetracycline-regulated (pro)insulin secretion and processing to mature insulin following plasmid-mediated transfection of human muscle	2003
Dr Kathleen Scougall Professor James Shaw	Tetracycline-regulated secretion of human insulin in a transfected non-endocrine cell line	2003
Dr Kathleen Scougall Professor James Shaw	Tetracycline-regulated secretion of human insulin in transfected primary myoblasts	2003
Professor James Shaw	Cushing's syndrome during pregnancy: Curative Adrenalectomy at 31 Weeks Gestation	2002
Professor James Shaw	Development of alternatives to insulin injection by genetic engineering	2002
Professor James Shaw	Genetic engineering in the treatment of diabetes	2002
Professor Nigel Unwin Professor James Shaw Emeritus Professor Sir George Sir George Alberti	Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention	2002
Professor James Shaw	Retrospective audit of individuals with Type 1 diabetes mellitus with and without altered hypoglycaemia awareness / severe hypoglycaemia attending Newcastle Diabetes Centre	2002
Professor James Shaw	Secretion of bioactive human insulin following plasm id-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo	2002
Emeritus Professor Sir George Sir George Alberti Professor James Shaw	Global and societal implications of the diabetes epidemic	2001
Dr Kathleen Scougall Professor James Shaw	Tetracycline-regulated secretion of mature human insulin in transfected primary rat myoblasts	2001
Dr Kathleen Scougall Professor James Shaw	Tetracycline-regulated secretion of human pro/insulin in transfected primary rat myoblasts	2000
Professor James Shaw	Gene therapy for type II diabetes: will it have a role?	1999
Professor James Shaw	Towards off the shelf gene therapy for diabetes: insulin expression in rats following intramuscular DNA injection	1999