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MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study

Lookup NU author(s): Gavin Cuthbert, Professor Christine Harrison FRCPath FMedSci, Dr Michael Griffiths, Dr Nicholas Bown

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Abstract

The MLL gene, located at 11q23, is frequently rearranged in acute leukaemia as either chimaeric fusion genes or partial tandem duplications. We report a series of 12 acute leukaemia cases with apparent amplification of the MLL gene ascertained using fluorescence in situ hybridisation (FISH). Seven cases showed intrachromosomal amplification of MLL, four cases showed extrachromosomal amplification as double minute chromosomes (dmin) and one case had separate subclones with dmin and homogenously staining region (hsr). Southern blot analysis of the MLL gene showed MLL gene rearrangement in three of the 10 successful cases. These cases do not naturally fall into either of the two recognised categories of MLL rearrangement and may represent a third variety of MLL gene abnormalities.

Publication metadata

Author(s): Cuthbert GD, Thompson K, McCullough S, Watmore A, Dickinson HO, Telford N, Mugneret F, Harrison C, Griffiths MJ, Bown NP

Publication type: Article

Publication status: Unknown

Journal: Leukemia

Year: 2000

Volume: 14

Issue: 11

Pages: 1885-1891

ISSN (print): 0887-6924

ISSN (electronic): 1476-5551

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/sj.leu.2401919

DOI: 10.1038/sj.leu.2401919

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