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Lookup NU author(s): Dr Johnny RoughanORCiD, Emeritus Professor Paul FlecknellORCiD, Professor John Dark
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Objective: Previous studies have suggested reductions in lung reperfusion injury with pentoxifylline, inositol polyanions, and the nitric oxide donor, SIN-1, but these agents have never been directly compared to ascertain which is superior. We investigated these agents in a porcine model of left single lung transplantation. Methods: Donor lungs were preserved with modified Euro-Collins solution for a mean ischemic time of 18.4 hours. Neutrophil trapping in the graft, pulmonary vascular resistance, free radical release (measured by malonaldehyde levels) and gas exchange were assessed over a 12-hour period. All groups were reperfused at an initial pulmonary artery pressure of 20 mm Hg, Group A (n = 5) was a control group with no interventions added; group B was reperfused with the addition of intravenous inositol polyanions (0.02 mg/kg/h), and group C was reperfused with intravenous SIN-1 (0.02 mg/kg/h), Group D was reperfused with the addition of intravenous pentoxifylline (2 mg/kg/h), Results: Neutrophil sequestration was observed within 10 minutes of reperfusion in group A. This was attenuated significantly by interventions in groups B, C, and D, In group D, malonaldehyde levels were significantly lower than in other groups and was associated with superior oxygenation. Pulmonary vascular resistance was reduced in groups B, C, and D compared with group A. Conclusions: Pentoxifylline, when administered only to recipient animals was superior to the other interventions studied. Inositol polyanions are promising as a possible therapeutic intervention but were not as effective as the other agents studied.
Author(s): Dark JH; Roughan J; Flecknell PA; Clark SC; Sudarshan C
Publication type: Article
Publication status: Published
Journal: Journal of Thoracic and Cardiovascular Surgery
Year: 1999
Volume: 117
Issue: 3
Pages: 556-564
Print publication date: 01/03/1999
ISSN (print): 0022-5223
ISSN (electronic): 1097-685X
Publisher: Mosby, Inc.
URL: http://dx.doi.org/10.1016/S0022-5223(99)70335-1
DOI: 10.1016/S0022-5223(99)70335-1
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