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Post-transcriptional control in the male germ line

Lookup NU author(s): Dr Ingrid Ehrmann, Professor David Elliott

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Abstract

Post-transcriptional mechanisms play an important role in the biology of germ cells, where they control key developmental decisions in cell division, differentiation and death. Because these post-transcriptional controls are cell-type-specific, and often utilize germ-cell-specific RNA-binding proteins, they provide useful diagnostic markers for male infertility and testicular cancer. Investigation of the genetics of male infertility in men and model organism suggests that disruption of post-transcriptional control mechanisms can cause specific germ cell pathologies, and these studies point to future possible therapeutic routes for restoring spermatogenesis.

Publication metadata

Author(s): Ehrmann I, Elliott DJ

Publication type: Article

Publication status: Published

Journal: Reproductive BioMedicine Online

Year: 2005

Volume: 10

Issue: 1

Pages: 55-63

Print publication date: 10/05/2010

ISSN (print): 1472-6483

ISSN (electronic): 1472-6491

Publisher: Elsevier Ltd

URL: http://dx.doi.org/10.1016/S1472-6483(10)60804-8

DOI: 10.1016/S1472-6483(10)60804-8

PubMed id: 15705295

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