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Lookup NU author(s): Dr Anne Lennard, Dr Nicholas Bown
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Rearrangements of MLL are regarded as primary oncogenic events in acute leukemia. We report the case of a patient with acute myeloid leukemia with a complex abnormal karyotype at diagnosis who showed a putative stem line with monosomy 5 and a rearrangement of chromosome 17 as the only abnormalities and an evolved clone with an additional t(7,16,11)(p1?4; p13;q23) after treatment. Fluorescence in situ hybridization analysis confirmed that the translocation had resulted in an MLL rearrangement not present in the stem line or in the complex clones found at diagnosis. To date, this is the first report of an MLL rearrangement evolving as a secondary abnormality within a preexisting leukemic clone. © 2002 Wiley-Liss, Inc.
Author(s): Rowe, D., Breese, G., Lennard, A.L., Bown, N.P.
Publication type: Article
Publication status: Published
Journal: Genes Chromosomes and Cancer
Year: 2002
Volume: 34
Issue: 1
Pages: 126-128
Print publication date: 01/01/2002
ISSN (print): 1045-2257
ISSN (electronic): 1098-2264
URL: http://dx.doi.org/10.1002/gcc.10011
DOI: 10.1002/gcc.10011
PubMed id: 11921290
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