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Early results of a non-heartbeating donor (NHBD) programme with machine perfusion

Lookup NU author(s): Basav Sen, Professor Derek Manas

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Abstract

Freeman Hospital, Newcastle upon Tyne restarted their non-heartbeating donor (NHBD) programme in September 1998 using machine perfusion, due to early poor results with conventional cold storage (45% graft survival, phase II). Since then, 15 NHBD kidneys have been transplanted. The retrieval protocol consisted of in situ perfusion with a double balloon triple lumen cannula in Maastricht category II male donors age range 13-59 years. Mean primary warm ischaemic time was 24.8 min (range 10-44). All kidneys were machine perfused through a locally developed perfusion system. The viability was assessed by serial measurements of total GST (maximum acceptable limit of 200 units/l) and intrarenal vascular resistance (IRVR) was recorded. Fifteen of the 22 kidneys (68.62%) were transplanted. Delayed graft function (DGF) was seen in ten recipients (66.6%), two kidneys had immediate function (IF), one organ was exported, two recipients died of unrelated causes and a further seven kidneys were discarded (two had high tGST, two were infected and three had poor flow characteristics). In phase III, a success rate of 91.7% was thus achieved, which was better than the phase II period (P = 0.027, Fisher 2-tail test). Machine perfusion has been successfully introduced in phase III to the Newcastle NHBD programme and facilitates viability assessment of NHBD kidneys. © Springer-Verlag 2000.

Publication metadata

Author(s): Balupuri S, Buckley P, Mohamad M, Chidambaram Y, Gerstenkorn C, Sen B, Kirby J, Manas DM, Talbot D

Publication type: Article

Publication status: Published

Journal: Transplant International

Year: 2000

Volume: 13

Issue: 1

Pages: S255-S258

ISSN (print): 0934-0874

ISSN (electronic): 1432-2277

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1432-2277.2000.tb02031.x/pdf

DOI: 10.1111/j.1432-2277.2000.tb02031.x

PubMed id: 11112007

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