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Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodies

Lookup NU author(s): Dr Calum Hamilton, Dr Paul DonaghyORCiD, Dr Michael FirbankORCiD, Nicola Barnett, Dr Louise Allan, Dr George Petrides, Professor John-Paul TaylorORCiD, Professor John O'Brien, Professor Alan ThomasORCiD

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Abstract

The aim of this study was to determine whether there was a significant change in cardiac [123I]-metaiodobenzylguanidine uptake between baseline and follow-up in individuals with mild cognitive impairment with Lewy bodies (MCI-LB) who had normal baseline scans. Eight participants with a diagnosis of probable MCI-LB and a normal baseline scan consented to a follow-up scan between 2 and 4 years after baseline. All eight repeat scans remained normal; however, in three cases uptake decreased by more than 10%. The mean change in uptake between baseline and repeat was −5.2% (range: −23.8% to +7.0%). The interpolated mean annual change in uptake was −1.6%.

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Author(s): Greenfinch G, Hamilton CA, Donaghy PC, Firbank M, Barnett NA, Allan L, Petrides GS, Taylor JP, O'Brien JT, Thomas AJ

Publication type: Article

Publication status: Published

Journal: BJPsych Open

Year: 2024

Volume: 10

Issue: 6

Online publication date: 05/12/2024

Acceptance date: 05/06/2024

Date deposited: 03/02/2025

ISSN (electronic): 2056-4724

Publisher: Cambridge University Press

URL: https://doi.org/10.1192/bjo.2024.766

DOI: 10.1192/bjo.2024.766

Data Access Statement: The data and materials that support the findings of this study are available from the corresponding author, G.G., upon reasonable request.

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