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Metformin and physical performance in older people with probable sarcopenia and physical prefrailty or frailty in England (MET-PREVENT): a double-blind, randomised, placebo-controlled trial

Lookup NU author(s): Professor Miles WithamORCiD, Dr Claire McDonald, Dr Nina WilsonORCiD, Katherine Rennie, Michelle Bardgett, Penny Bradley, Professor Helen HancockORCiD, Shaun HiuORCiD, Dr Karen Nicholson, Laura Robertson, Laura Simms, Dr Alison SteelORCiD, Bryony Storey, Professor James WasonORCiD, Professor Thomas von Zglinicki, Professor Avan SayerORCiD

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Author(s): Witham MD, McDonald C, Wilson N, Rennie KJ, Bardgett M, Bradley P, Clegg AP, Connolly S, Hancock H, Hiu S, Nicholson K, Robertson L, Simms L, Steel AJ, Steves CJ, Storey B, Wason J, von Zglinicki T, Sayer AA

Publication type: Article

Publication status: Published

Journal: Lancet Healthy Longevity

Year: 2025

Volume: 6

Issue: 3

Online publication date: 24/03/2025

Acceptance date: 31/01/2025

Date deposited: 31/01/2025

ISSN (electronic): 2666-7568

Publisher: Lancet Publishing Group

URL: https://doi.org/10.1016/j.lanhl.2025.100695

DOI: 10.1016/j.lanhl.2025.100695

Data Access Statement: De-identified individual participant-level data from this trial are stored at the NIHR Newcastle Biomedical Research Centre and will be made available to other researchers subject to completion of appropriate collaboration agreements and data sharing agreements with the trial team. For access to trial documents (information sheet, consent form, protocol, statistical analysis plan), contact the chief investigator (Miles.Witham@newcastle.ac.uk).

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