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Effect of active carbonyl-carboxyl ratio on dynamic Schiff base crosslinking and its modulation of high-performance oxidized starch-chitosan hydrogel by hot extrusion 3D printing

Lookup NU author(s): Professor David XieORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

The quest to develop 3D starch-based printing hydrogels for the controlled release of active substances with excellent mechanical and printing properties has gained significant attention. This work introduced a facile method based on crosslinking via Schiff base reaction for preparing bicomponent hydrogels. The method involved the utilization of customizable oxidized starch (OS) and chitosan (CS), enabling superior printing performance through the precise control of various active carbonyl-carboxyl ratios (ACR, 2:1, 1:1, and 2:3, respectively) of OS. OS-CS hydrogel (OSC) with an ACR level of 2:1 (OS-2-y%CS) underwent rearrangement during printing environment, fostering increased Schiff base reaction with a higher crosslinking degree and robust high structural recovery (>95 %). However, with decreasing ACR levels (from 2:1 to 2:3), the printing performance and mechanical strength of printed OSC (POSC) declined due to lower Schiff base bonds and increased phase separation. Compared with printed OS, POS-2-2%CS exhibited a remarkable 1250.52 % increase in tensile strength and a substantial 2424.71 % boost in compressive strength, enhanced shape fidelity and notable self-healing properties. Moreover, POS-2-2%CS exhibited stable diffusive drug release, showing potential application in the pH-responsive release of active substances. Overall, controlling the active carbonyl-carboxyl ratios provided an efficient and manageable approach for preparing high-performance 3D-printed hydrogels.


Publication metadata

Author(s): Zhu J, Xie F, Qiu Z, Chen L

Publication type: Article

Publication status: Published

Journal: Carbohydrate Polymers

Year: 2024

Volume: 343

Print publication date: 01/11/2024

Online publication date: 30/06/2024

Acceptance date: 25/06/2024

Date deposited: 09/07/2024

ISSN (print): 0144-8617

ISSN (electronic): 1879-1344

Publisher: Elsevier

URL: https://doi.org/10.1016/j.carbpol.2024.122438

DOI: 10.1016/j.carbpol.2024.122438

ePrints DOI: 10.57711/y14c-0t06

Data Access Statement: Data will be made available on request.


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Funding

Funder referenceFunder name
National Natural Science Foundation of China

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