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An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

Lookup NU author(s): Professor Fiona OakleyORCiD, Dr Simon CockellORCiD, Dr Olivier Govaere, Professor Ann DalyORCiD, Professor Arun Sanyal, Dr Massimo Younes, Professor Alastair BurtORCiD, Professor Pierre Bedossa, Professor Quentin AnsteeORCiD, Professor Dina Tiniakos

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


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Author(s): Vacca V, Kamzolas I, Mørch Harder L, Oakley F, Trautwein C, Hatting M, Ross T, Bernardo B, Oldenburger A, Toftegaard Hjuler S, Ksiazek I, Linden D, Schuppan D, Rodriguez-Cuenca S, Manuela Tonini M, Castañeda TR, Kannt A, Rodrigues CMP, Cockell S, Govaere O, Daly AK, Allison M, Honnens de Lichtenberg K, Kim YO, Lindblom A, Oldam S, Andréasson A-C, Schlerman F, Marioneaux J, Sanyal A, Afonso MB, Younes R, Amano Y, Friedman SL, Wang S, Bhattacharya D, Simon E, Paradis V, Burt A, Grypari IM, Davies S, Driessen A, Yashiro H, Pors S, Worm Andersen M, Feigh M, Yunis C, Bedossa P, Stewart M, Cater HL, Wells S, Schattenberg JM, Anstee QM, The LITMUS Investigators, Tiniakos D, Perfield JW, Petsalaki E, Davidsen P, Vidal-Puig A

Publication type: Article

Publication status: Published

Journal: Nature Metabolism

Year: 2024

Volume: 6

Pages: 1178-1196

Online publication date: 12/06/2024

Acceptance date: 08/04/2024

Date deposited: 12/06/2024

ISSN (electronic): 2522-5812

Publisher: Springer Nature

URL: https://doi.org/10.1038/s42255-024-01043-6

DOI: 10.1038/s42255-024-01043-6

Data Access Statement: All the murine data in this manuscript are original and unpublished except for 6J-WD-C0.2-32W (GSE110404), R-CDAA (GSE134715) and GAN-C2 REV/SEMA (GSE196908), which have been previously published and the raw data reused. Murine gene expression datasets have been deposited in the Array Express database (next-generation sequencing (NGS) accession number E-MTAB-12808; microarrays accession number E-MTAB-12817). All processed data used in or produced by this analysis have been deposited in Biostudies (accession number S-BSST1361; https://www.ebi.ac.uk/biostudies/studies/S-BSST1361), along with all murine metadata necessary for the interpretation, validation and expansion of the findings presented in this study. For those animals with available expression data, all metadata have also been deposited to the Array Express database. Human gene expression datasets and some metadata are publicly available (E-MTAB-9815, GSE130970, GSE135251); additional metadata are available upon request.

PubMed id: 38867022


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Funding

Funder referenceFunder name
777377European Commission

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