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Starch film-coated microparticles for oral colon-specific drug delivery

Lookup NU author(s): Professor David XieORCiD

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).


Abstract

The aim of this study was to prepare and characterize a novel type of starch-coated microparticles (MPs) allowing site-specific delivery of bioactives to the colon. An oral colon-specific controlled-release system was developed in the form of MPs coated with a resistant starch (RS2/RS3) film (RS@MPs) through an aqueous suspension coating process. The RS2 was chosen from a high-amylose cornstarch with 88.5% digestion resistibility. The RS3 was prepared by a high-temperature/pressure (HTP) treatment, with the following of enzymatic debranching, and retrogradation, resulting in a dramatic increase in enzymatic resistance (RS3 content: 76.6%). RS@MPs showed 40.7% of 5-aminosalicylic acid release within 8 h. The in vivo study of fluorescein-loaded RS@MPs indicated the high acidic and enzymatic resistibility of RS@MPs and a restrained release in the upper GIT. Therefore, RS@MPs has revealed to be a high potential system for accurately targeting bioactive compound delivery to the colon.


Publication metadata

Author(s): Chen J, Li X, Chen L, Xie F

Publication type: Article

Publication status: Published

Journal: Carbohydrate Polymers

Year: 2018

Volume: 191

Pages: 242-254

Print publication date: 01/07/2018

Online publication date: 14/03/2018

Acceptance date: 13/03/2018

Date deposited: 31/08/2023

ISSN (print): 0144-8617

ISSN (electronic): 1879-1344

Publisher: Elsevier

URL: https://doi.org/10.1016/j.carbpol.2018.03.025

DOI: 10.1016/j.carbpol.2018.03.025


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Funding

Funder referenceFunder name
2014YT02S029
National Natural Science Foundation of China (NSFC)–Guangdong Joint Foundation Key Project
U1501214
YangFan Innovative and Entrepreneurial Research Team Project

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