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Lookup NU author(s): Dr Gary ReynoldsORCiD, Dr Peter Vegh, Dr James Fletcher, Dr Beth Poyner, Dr Emily StephensonORCiD, Issac Goh, Dr Rachel Botting, Dr Bayanne Olabi, Dr Anna Dubois, David Dixon, Dr Kile GreenORCiD, Dan Maunder, Justin Engelbert, Dr Laura JardineORCiD, Claire Jones, Dave Horsfall, Jim McGrath, Dr Christopher Carey, Dr Dorin-Mirel Popescu, Dr Simone Webb, Dr Xiao WangORCiD, Dr David McDonald, Professor Andrew FilbyORCiD, Dr Akhtar Husain, Dr Jonathan Coxhead, Dr Roser Vento-Tormo, Dr Steven LisgoORCiD, Professor Jaume Bacardit, Professor Neil RajanORCiD, Professor Nick ReynoldsORCiD, Professor Muzlifah Haniffa
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© 2021 American Association for the Advancement of Science. All rights reserved.The skin confers biophysical and immunological protection through a complex cellular network established early in embryonic development. We profiled the transcriptomes of more than 500,000 single cells from developing human fetal skin, healthy adult skin, and adult skin with atopic dermatitis and psoriasis. We leveraged these datasets to compare cell states across development, homeostasis, and disease. Our analysis revealed an enrichment of innate immune cells in skin during the first trimester and clonal expansion of disease-associated lymphocytes in atopic dermatitis and psoriasis. We uncovered and validated in situ a reemergence of prenatal vascular endothelial cell and macrophage cellular programs in atopic dermatitis and psoriasis lesional skin. These data illustrate the dynamism of cutaneous immunity and provide opportunities for targeting pathological developmental programs in inflammatory skin diseases.
Author(s): Reynolds G, Vegh P, Fletcher J, Poyner EFM, Stephenson E, Goh I, Botting RA, Huang N, Olabi B, Dubois A, Dixon D, Green K, Maunder D, Engelbert J, Efremova M, Polański K, Jardine L, Jones C, Ness T, Horsfall D, McGrath J, Carey C, Popescu D-M, Webb S, Wang X-N, Sayer B, Park J-E, Negri VA, Belokhvostova D, Lynch MD, McDonald D, Filby A, Hagai T, Meyer KB, Husain A, Coxhead J, Vento-Tormo R, Behjati S, Lisgo S, Villani A-C, Bacardit J, Jones PH, O'Toole EA, Ogg GS, Rajan N, Reynolds NJ, Teichmann SA, Watt FM, Haniffa M
Publication type: Article
Publication status: Published
Journal: Science
Year: 2021
Volume: 371
Issue: 6527
Print publication date: 22/01/2021
Acceptance date: 02/04/2018
ISSN (print): 0036-8075
ISSN (electronic): 1095-9203
Publisher: American Association for the Advancement of Science
URL: https://doi.org/10.1126/science.aba6500
DOI: 10.1126/science.aba6500
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