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Lookup NU author(s): Stella Victorelli, Dr Joao Passos
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Cumulative evidence suggests that cellular senescence plays a variety of important physiological roles, including tumor suppression, embryonic development and ageing. Senescent cells are characterized by increased production of reactive oxygen species (ROS), mostly produced by dysfunctional mitochondria. Both intracellular and extracellular ROS have been shown to contribute to the induction of senescence. ROS have also been shown to act as signaling molecules during senescence, stabilizing the cell-cycle arrest. In this chapter, we present a detailed description of protocols that allow us to characterize intracellular and extracellular ROS in live senescent cells.
Author(s): Victorelli S, Passos JF
Editor(s): Marco Demaria
Publication type: Book Chapter
Publication status: Published
Book Title: Cellular Senescence: Methods and Protocols
Year: 2019
Volume: 1896
Pages: 21-29
Acceptance date: 02/04/2018
Series Title: Methods in Molecular Biology
Publisher: Humana Press
Place Published: New York
URL: https://doi.org/10.1007/978-1-4939-8931-7_3
DOI: 10.1007/978-1-4939-8931-7_3
PubMed id: 30474836
Library holdings: Search Newcastle University Library for this item
ISBN: 9781493989300