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Lookup NU author(s): Dr Jane Margetts, Laura Ogle, Dr Anthony Chan, Dr David Jamieson, Dr Catherine WilloughbyORCiD, Professor Derek Mann, Dr Caroline WilsonORCiD, Professor Derek Manas, Professor Helen ReevesORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0).
Background Irrespective of the underlying aetiology, 90% of hepatocellular carcinomas(HCC) arise and progress on a background of chronic inflammation. We have explored theindependent prognostic value of circulating inflammatory cells.Methods Peripheral blood count datasets from 583 consecutive patients presenting to asingle UK centre (2000–2010) were analysed for associations with tumour stage, liverfunction, performance status (PST) and survival. Validation was in an independent HongKong cohort (585 patients; 2007-2013).Results In both UK and Hong Kong cohorts, neutrophils, platelets, lymphocytes, theneutrophil/lymphocyte ratio (NLR), and the Systemic immune-inflammation index (SII)correlated stepwise, either increasing or decreasing (lymphocytes), with TNM and Childs-Pugh stage, PST and consequently with the combined Barcelona Clinic for Liver Cancer(BCLC) stage. Survival analyses confirmed the NLR and SII as highly significant prognosticbiomarkers. Focused on individual cell types, only the neutrophil count was independentlyassociated with both TNM stage and PST, as well as being significantly and independentlyassociated with poorer survival.Conclusion In this study of 1168 patients, neutrophils alone, rather than lymphocytes orplatelets, were independently associated with outcome. These data support furthercharacterisation of a potentially distinctive role for neutrophils as facilitators of tumourprogression and deteriorating performance.
Author(s): Margetts J, Ogle LF, Chan SL, Chan AWH, Chan KCA, Jamieson D, Willoughby CE, Mann DA, Wilson CL, Manas DM, Yeo W, Reeves HL
Publication type: Article
Publication status: Published
Journal: British Journal of Cancer
Year: 2018
Volume: 118
Pages: 248-257
Online publication date: 09/11/2017
Acceptance date: 09/10/2017
Date deposited: 28/11/2017
ISSN (print): 0007-0920
ISSN (electronic): 1532-1827
Publisher: Nature Publishing Group
URL: https://doi.org/10.1038/bjc.2017.386
DOI: 10.1038/bjc.2017.386
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