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Mechanisms driving the ageing heart

Lookup NU author(s): Rhys Anderson, Professor Gavin RichardsonORCiD, Dr Joao Passos

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Abstract

Cardiovascular disease (CVD) is the leading cause of death globally. Although the number one risk factor for CVD is age, the detrimental biological processes that occur in the heart during ageing remain elusive. It is therefore vitality important to understand the fundamental mechanisms driving heart ageing to enable the development of preventions and treatments targeting these processes. Cellular senescence has been described more than fifty years ago as the irreversible cell-cycle arrest which occurs in somatic cells. Emerging evidence suggests that cellular senescence plays a key role in heart ageing, however the cell-types involved and the underlying mechanisms are not yet elucidated. In this review we discuss the current understanding of how mechanisms known to contribute to senescence impact on heart ageing and CVD. Finally, we will review recent data suggesting that targeting senescent cells may be a viable therapy to counteract the ageing of the heart.

Publication metadata

Author(s): Anderson R, Richardson GD, Passos JF

Publication type: Article

Publication status: Published

Journal: Experimental Gerontology

Year: 2018

Volume: 109

Pages: 5-15

Print publication date: 01/08/2018

Online publication date: 18/10/2017

Acceptance date: 16/10/2017

ISSN (print): 0531-5565

ISSN (electronic): 1873-6815

Publisher: Elsevier

URL: https://doi.org/10.1016/j.exger.2017.10.015

DOI: 10.1016/j.exger.2017.10.015

PubMed id: 29054534

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