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Detection of l-alanylaminopeptidase activity in microorganisms using chromogenic self-immolative enzyme substrates

Lookup NU author(s): Dr John Perry

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Abstract

© 2017. Three potential chromogenic enzymatic probes, each possessing a self-immolative spacer unit, were synthesised for the purpose of detecting l-alanylaminopeptidase activity in microorganisms. An Alizarin-based probe was the most effective, allowing several species to generate strongly coloured colonies in the presence of metal ions.

Publication metadata

Author(s): Cellier M, James AL, Orenga S, Perry JD, Rasul AK, Stanforth SP

Publication type: Article

Publication status: Published

Journal: Bioorganic and Medicinal Chemistry Letters

Year: 2017

Volume: 27

Issue: 10

Pages: 2102-2106

Online publication date: 28/03/2017

Acceptance date: 25/03/2017

ISSN (print): 0960-894X

ISSN (electronic): 1464-3405

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.bmcl.2017.03.080

DOI: 10.1016/j.bmcl.2017.03.080

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