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The role of antigen-presenting cells in the regulation of allergen-specific T cell responses

Lookup NU author(s): Professor Catharien Hilkens

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Abstract

Allergic reactions in atopic patients follow from a generalized enhanced polarization of Th cells, predominantly imposed by factors derived from antigen-presenting cells from a pathogen-stressed tissue; these sample information not only on antigen structures but also on the nature of the stress. Antigen-presenting cells of atopic individuals show aberrant characteristics which, through a highly interactive communication network, play an active role in aberrant Th-cell polarization. This generalized bias may follow from intrinsic abnormalities of antigen-presenting cells and also from a low degree of cross-regulation by micro-organisms.

Publication metadata

Author(s): Kapsenberg ML, Hilkens CM, Wierenga EA, Kalinski P

Publication type: Article

Publication status: Published

Journal: Current Opinion in Immunology

Year: 1998

Volume: 10

Issue: 6

Pages: 607-613

Print publication date: 01/12/1998

ISSN (print): 0952-7915

ISSN (electronic): 1879-0372

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/S0952-7915(98)80077-0

DOI: 10.1016/S0952-7915(98)80077-0

Notes: 0952-7915 Journal Article Review Review, Tutorial

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