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Mitochondria: Are they causal players in cellular senescence?

Lookup NU author(s): Dr Clara Correia Melo, Dr Joao Passos

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Abstract

Cellular senescence entails an irreversible cell-cycle arrest characterised by drastic cytomorphological and metabolic changes. In recent years, the implications of cellular senescence in physiological and pathological settings, such as ageing and cancer, have gained firm ground. It is, therefore, important to understand the mechanisms underpinning the establishment and maintenance of senescence. Age-dependent alterations in cellular metabolic processes are greatly driven by changes in mitochondrial function and homeostasis. Classically, mitochondrial dysfunction has been implicated in cellular senescence mainly by promoting oxidative damage-induced cell-cycle arrest; however, emerging data suggests that other mitochondrial-dependent factors play an important role in the induction of senescent phenotypes. Here we review the role of mitochondrial homeostatic mechanisms, mitochondrial metabolites and ROS generation in the signalling pathways leading to the induction and maintenance of cellular senescence and discuss how this may contribute to the ageing process. This article is part of a Special Issue entitled: Mitochondrial Dysfunction in Aging. (c) 2015 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Correia-Melo C, Passos JF

Publication type: Review

Publication status: Published

Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year: 2015

Volume: 1847

Issue: 11

Pages: 1373-1379

Print publication date: 01/11/2015

Online publication date: 28/05/2015

Acceptance date: 21/05/2015

ISSN (print): 0005-2728

ISSN (electronic): 0006-3002

Publisher: ELSEVIER SCIENCE BV

URL: http://dx.doi.org/10.1016/j.bbabio.2015.05.017

DOI: 10.1016/j.bbabio.2015.05.017

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