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Lookup NU author(s): Dr Beate Haugk, Richard Charnley
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Transcription factor NF-E2 p45-related factor 2 (Nrf2, also called Nfe2l2), a master regulator of redox homeostasis, and its dominant negative regulator, Kelch-like ECH-associated protein 1 (Keap1), together tightly control the expression of numerous detoxifying and antioxidant genes. Nrf2 and the 'antioxidant response element' (ARE)-driven genes it controls are frequently upregulated in pancreatic cancer and correlate with poor survival. Upregulation of Nrf2 is, at least in part, K-Ras oncogene-driven and contributes to pancreatic cancer proliferation and chemoresistance. In this review, we aim to provide an overview of Keap1-Nrf2 signalling as it relates to pancreatic cancer, discussing the effects of inhibiting Nrf2 or Nrf2/ARE effector proteins to increase chemosensitivity. (C) 2015 Elsevier Ltd. All rights reserved.
Author(s): Hayes AJ, Skouras C, Haugk B, Charnley RM
Publication type: Review
Publication status: Published
Journal: The International Journal of Biochemistry & Cell Biology
Year: 2015
Volume: 65
Pages: 288-299
Print publication date: 01/08/2015
Online publication date: 24/06/2015
Acceptance date: 22/06/2015
ISSN (print): 1357-2725
ISSN (electronic): 1878-5875
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
URL: http://dx.doi.org/10.1016/j.biocel.2015.06.017
DOI: 10.1016/j.biocel.2015.06.017
