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Lookup NU author(s): Dr John Perry
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Several novel fluorogenic N-aminoacylnaphthyridine substrates were synthesized in good yield and tested for their ability to detect pathogenic bacteria in agar-based cell culture. Simple 2-N-(beta-alanyl)amino-5,7-dialkylnaphthyridine substrates were selectively hydrolysed by beta-alanylaminopeptidase expressing bacteria, but were subject to diffusion in the agar medium. Diffusion was reduced in the 2-N-(beta-alanyl)amino-7-alkylnaphthyridine substrates with longer alkyl chains, but inhibition of growth was increased. 2-N-(beta-Alanyl)amino-7-octylnaphthyridine inhibited the growth of all species tested, except for strains resistant to colistin/polymyxin, providing a rationale for the development of substrates for the selective detection of drug resistant species in clinical samples.
Author(s): Varadi L, Gray M, Groundwater PW, Hall AJ, James AL, Orenga S, Perry JD, Anderson RJ
Publication type: Article
Publication status: Published
Journal: Organic & Biomolecular Chemistry
Year: 2012
Volume: 10
Issue: 13
Pages: 2578-2589
Print publication date: 23/01/2012
ISSN (print): 1477-0520
ISSN (electronic): 1477-0539
Publisher: RSC Publications
URL: http://dx.doi.org/10.1039/c2ob06986e
DOI: 10.1039/c2ob06986e
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