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Lookup NU author(s): Dr Kate Potter, Dr Jane Ng, Professor Caroline Relton
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Maternal smoking during pregnancy is associated with low birth weight. Common variation at rs1051730 is robustly associated with smoking quantity and was recently shown to influence smoking cessation during pregnancy, but its influence on birth weight is not clear. We aimed to investigate the association between this variant and birth weight of term, singleton offspring in a well-powered meta-analysis. We stratified 26 241 European origin study participants by smoking status (women who smoked during pregnancy versus women who did not smoke during pregnancy) and, in each stratum, analysed the association between maternal rs1051730 genotype and offspring birth weight. There was evidence of interaction between genotype and smoking (P 0.007). In women who smoked during pregnancy, each additional smoking-related T-allele was associated with a 20 g [95 confidence interval (95 CI): 436 g] lower birth weight (P 0.014). However, in women who did not smoke during pregnancy, the effect size estimate was 5 g per T-allele (95 CI: 4to 14 g; P 0.268). To conclude, smoking status during pregnancy modifies the association between maternal rs1051730 genotype and offspring birth weight. This strengthens the evidence that smoking during pregnancy is causally related to lower offspring birth weight and suggests that population interventions that effectively reduce smoking in pregnant women would result in a reduced prevalence of low birth weight.
Author(s): Tyrrell J, Huikari V, Christie JT, Cavadino A, Bakker R, Brion MJA, Geller F, Paternoster L, Myhre R, Potter C, Johnson PCD, Ebrahim S, Feenstra B, Hartikainen AL, Hattersley AT, Hofman A, Kaakinen M, Lowe LP, Magnus P, McConnachie A, Melbye M, Ng JWY, Nohr EA, Power C, Ring SM, Sebert SP, Sengpiel V, Taal HR, Watt GCM, Sattar N, Relton CL, Jacobsson B, Frayling TM, Srensen TIA, Murray JC, Lawlor DA, Pennell CE, Jaddoe VWV, Hypponen E, Lowe WL, Jarvelin MR, Smith GD, Freathy RM, Early Growth Genetics EGG
Publication type: Article
Publication status: Published
Journal: Human Molecular Genetics
Year: 2012
Volume: 21
Issue: 24
Pages: 5344-5358
Print publication date: 05/09/2012
ISSN (print): 0964-6906
ISSN (electronic): 1460-2083
Publisher: Oxford University Press
URL: http://dx.doi.org/10.1093/hmg/dds372
DOI: 10.1093/hmg/dds372
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