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Epigenetic Control of Embryonic Stem Cell Differentiation.

Lookup NU author(s): Professor Lyle Armstrong

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Abstract

Pluripotent embryonic stem cells can give rise to almost all somatic cell types but this characteristic requires precise control of their gene expression patterns. The necessity of keeping the entire genome "poised" to enter into any of a number of developmental possibilities requires a unique and highly plastic chromatin organisation based around specific patterns of histone modifications although this state of affairs is normally short lived during embryonic development. By deriving embryonic stem cells from the early embryo, we can preserve the highly specialised genome organisation and this has permitted several detailed investigations into the molecular basis of pluripotency.

Publication metadata

Author(s): Armstrong L

Publication type: Article

Publication status: Published

Journal: Stem Cell Reviews and Reports

Year: 2012

Volume: 8

Issue: 1

Pages: 67-77

Print publication date: 01/03/2012

ISSN (print): 1550-8943

ISSN (electronic): 1558-6804

Publisher: Humana Press, Inc.

URL: http://dx.doi.org/10.1007/s12015-011-9300-4

DOI: 10.1007/s12015-011-9300-4

PubMed id: 21808982

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