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Lookup NU author(s): Dr Michael FirbankORCiD, Dr Louise Allan, Dr Emma Burton, Dr Robert Barber, Professor John O'Brien, Professor Raj KalariaORCiD
Background Stroke is a risk factor for subsequent death and dementia. Being able to identify subjects at particular risk would be beneficial to inform treatment and patient management. Methods Subjects aged over 75 years with incident stroke were recruited. Subjects had a cognitive assessment at 3 months post stroke to exclude dementia, and had an MRI scan (n = 106) at that time. Subjects were then followed longitudinally for incident dementia and/or death. Results Independent neuroimaging predictors of survival to dementia were medial temporal atrophy (MTA; p = 0.013) and the presence of thalamic infarcts (p = 0.002). After inclusion of cognitive score in the model, the significance of MTA (p = 0.049) and thalamic infarcts (p = 0.04) was reduced, with survival being best predicted by baseline cognitive score (p = 0.004). The only independent significant predictor of survival to death was MTA. Apart from thalamic infarcts, the NINDS/AIREN neuroimaging criteria did not independently predict survival to death or dementia. Conclusions MTA was associated with shorter time to dementia, suggesting a role for Alzheimer pathology in the development of post stroke dementia.
Author(s): Firbank MJ, Allan LM, Burton EJ, Barber R, O'Brien JT, Kalaria RN
Publication type: Article
Publication status: Published
Journal: Journal of Neurology, Neurosurgery and Psychiatry
Year: 2012
Volume: 83
Issue: 3
Pages: 263-267
Print publication date: 23/11/2011
Date deposited: 29/03/2012
ISSN (print): 0022-3050
ISSN (electronic):
Publisher: BMJ Group
URL: http://dx.doi.org/10.1136/jnnp-2011-300873
DOI: 10.1136/jnnp-2011-300873
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